Gene description for CD79B
Gene name CD79b molecule, immunoglobulin-associated beta
Gene symbol CD79B
Other names/aliases AGM6
B29
IGB
Species Homo sapiens
 Database cross references - CD79B
ExoCarta ExoCarta_974
Entrez Gene 974
HGNC 1699
MIM 147245
UniProt P40259  
 CD79B identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for CD79B
Molecular Function
    protein binding GO:0005515 IPI
    transmembrane signaling receptor activity GO:0004888 IEA
Biological Process
    B cell receptor signaling pathway GO:0050853 IEA
    immune response GO:0006955 TAS
    signal transduction GO:0007165 TAS
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 TAS
    B cell receptor complex GO:0019815 IEA
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 TAS
    external side of plasma membrane GO:0009897 IEA
 Experiment description of studies that identified CD79B in exosomes
1
Experiment ID 80
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 81
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for CD79B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD79A  
Affinity Capture-Western Homo sapiens
2 SYK 6850
Reconstituted Complex Homo sapiens
3 CD19 930
Invivo Homo sapiens
4 BLK 640
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CD79B is involved
PathwayEvidenceSource
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome





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