Gene description for CD19
Gene name CD19 molecule
Gene symbol CD19
Other names/aliases B4
CVID3
Species Homo sapiens
 Database cross references - CD19
ExoCarta ExoCarta_930
Entrez Gene 930
HGNC 1633
MIM 107265
UniProt P15391  
 CD19 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for CD19
Molecular Function
    receptor signaling protein activity GO:0005057 TAS
    protein binding GO:0005515 IPI
Biological Process
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    cellular defense response GO:0006968 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    innate immune response GO:0045087 TAS
    B cell receptor signaling pathway GO:0050853 IEA
    regulation of immune response GO:0050776 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 TAS
    extracellular exosome GO:0070062 IDA
    protein complex GO:0043234 IDA
    intracellular GO:0005622 TAS
    external side of plasma membrane GO:0009897 IDA
 Experiment description of studies that identified CD19 in exosomes
1
Experiment ID 79
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for CD19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFITM1 8519
Affinity Capture-Western Homo sapiens
2 CD81 975
Affinity Capture-Western Homo sapiens
3 CBL 867
Invivo Homo sapiens
4 PIK3R1 5295
Invivo Homo sapiens
5 SYK 6850
Invivo Homo sapiens
6 VAV1 7409
Invivo Homo sapiens
7 CR2 1380
Affinity Capture-Western Homo sapiens
8 CD9 928
Invivo Homo sapiens
9 VAV2  
Invivo Homo sapiens
Invitro Homo sapiens
10 CD79A  
Invivo Homo sapiens
11 CD22 933
Invivo Homo sapiens
12 CD82 3732
Invivo Homo sapiens
13 CD79B 974
Invivo Homo sapiens
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