Gene description for CD19
Gene name CD19 molecule
Gene symbol CD19
Other names/aliases B4
CVID3
Species Homo sapiens
 Database cross references - CD19
ExoCarta ExoCarta_930
Vesiclepedia VP_930
Entrez Gene 930
HGNC 1633
MIM 107265
UniProt P15391  
 CD19 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for CD19
Biological Process
    B-1 B cell differentiation GO:0001923 IEA
    B cell proliferation involved in immune response GO:0002322 IDA
    B cell proliferation involved in immune response GO:0002322 IMP
    immunoglobulin mediated immune response GO:0016064 IMP
    antigen receptor-mediated signaling pathway GO:0050851 IDA
    B cell receptor signaling pathway GO:0050853 IBA
    B cell receptor signaling pathway GO:0050853 ISS
    regulation of B cell receptor signaling pathway GO:0050855 IMP
    regulation of B cell activation GO:0050864 IDA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IDA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    protein-containing complex GO:0032991 IDA
    membrane raft GO:0045121 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CD19 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for CD19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANKRD16  
Affinity Capture-MS Homo sapiens
2 IFITM1 8519
Affinity Capture-Western Homo sapiens
3 CD81 975
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 POLR2M  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CD9 928
Affinity Capture-Western Homo sapiens
6 B3GNT3 10331
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SYK 6850
Affinity Capture-Western Homo sapiens
8 VAV1 7409
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 VAV2 7410
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 FAM188A 80013
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CD79A  
Affinity Capture-Western Homo sapiens
12 CR2 1380
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 CD22 933
Affinity Capture-Western Homo sapiens
14 CD82 3732
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
15 IGSF8 93185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CD79B 974
Affinity Capture-Western Homo sapiens
17 ECT2 1894
Two-hybrid Homo sapiens
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