Gene description for SYK
Gene name spleen tyrosine kinase
Gene symbol SYK
Other names/aliases p72-Syk
Species Homo sapiens
 Database cross references - SYK
ExoCarta ExoCarta_6850
Vesiclepedia VP_6850
Entrez Gene 6850
HGNC 11491
MIM 600085
UniProt P43405  
 SYK identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Hepatocytes 26054723    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
 Gene ontology annotations for SYK
Molecular Function
    phosphotyrosine residue binding GO:0001784 IPI
    protein kinase activity GO:0004672 IDA
    protein kinase activity GO:0004672 NAS
    protein serine/threonine kinase activity GO:0004674 IDA
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 IBA
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 IMP
    protein tyrosine kinase activity GO:0004713 ISS
    protein tyrosine kinase activity GO:0004713 NAS
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IGI
    non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS
    signaling receptor binding GO:0005102 IPI
    integrin binding GO:0005178 IPI
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    interleukin-15 receptor binding GO:0016170 IPI
    kinase activity GO:0016301 IDA
    protein kinase binding GO:0019901 IEA
    phosphatase binding GO:0019902 IEA
    Toll-like receptor binding GO:0035325 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    SH2 domain binding GO:0042169 IEA
    phospholipase binding GO:0043274 IPI
    scaffold protein binding GO:0097110 IPI
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    angiogenesis GO:0001525 IEA
    cell activation GO:0001775 ISS
    lymph vessel development GO:0001945 ISS
    positive regulation of receptor internalization GO:0002092 IEA
    stimulatory C-type lectin receptor signaling pathway GO:0002223 ISS
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    adaptive immune response GO:0002250 IBA
    adaptive immune response GO:0002250 ISS
    macrophage activation involved in immune response GO:0002281 IBA
    macrophage activation involved in immune response GO:0002281 ISS
    neutrophil activation involved in immune response GO:0002283 IBA
    neutrophil activation involved in immune response GO:0002283 ISS
    leukocyte activation involved in immune response GO:0002366 ISS
    serotonin secretion by platelet GO:0002554 ISS
    cell surface pattern recognition receptor signaling pathway GO:0002752 IMP
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 TAS
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    protein import into nucleus GO:0006606 IMP
    leukocyte cell-cell adhesion GO:0007159 IDA
    integrin-mediated signaling pathway GO:0007229 ISS
    integrin-mediated signaling pathway GO:0007229 NAS
    animal organ morphogenesis GO:0009887 TAS
    regulation of platelet activation GO:0010543 ISS
    regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    peptidyl-tyrosine phosphorylation GO:0018108 IGI
    peptidyl-tyrosine phosphorylation GO:0018108 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 ISS
    leukotriene biosynthetic process GO:0019370 IEA
    calcium-mediated signaling GO:0019722 IEA
    platelet activation GO:0030168 TAS
    B cell differentiation GO:0030183 IEA
    neutrophil chemotaxis GO:0030593 IDA
    positive regulation of protein-containing complex assembly GO:0031334 IMP
    receptor internalization GO:0031623 ISS
    positive regulation of type I interferon production GO:0032481 IEA
    positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 IEA
    positive regulation of interleukin-10 production GO:0032733 IMP
    positive regulation of interleukin-12 production GO:0032735 IMP
    positive regulation of interleukin-3 production GO:0032752 IEA
    positive regulation of interleukin-4 production GO:0032753 ISS
    positive regulation of interleukin-6 production GO:0032755 IMP
    positive regulation of interleukin-8 production GO:0032757 IMP
    positive regulation of tumor necrosis factor production GO:0032760 IMP
    positive regulation of mast cell cytokine production GO:0032765 IEA
    regulation of superoxide anion generation GO:0032928 ISS
    positive regulation of superoxide anion generation GO:0032930 IMP
    positive regulation of cell adhesion mediated by integrin GO:0033630 IBA
    positive regulation of cell adhesion mediated by integrin GO:0033630 ISS
    intracellular signal transduction GO:0035556 IDA
    intracellular signal transduction GO:0035556 IGI
    intracellular signal transduction GO:0035556 IMP
    intracellular signal transduction GO:0035556 ISS
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    interleukin-3-mediated signaling pathway GO:0038156 ISS
    gamma-delta T cell differentiation GO:0042492 IEA
    defense response to bacterium GO:0042742 ISS
    mast cell degranulation GO:0043303 IEA
    positive regulation of mast cell degranulation GO:0043306 IEA
    regulation of neutrophil degranulation GO:0043313 ISS
    beta selection GO:0043366 IEA
    positive regulation of MAPK cascade GO:0043410 IEA
    innate immune response GO:0045087 ISS
    positive regulation of B cell differentiation GO:0045579 IMP
    positive regulation of gamma-delta T cell differentiation GO:0045588 IEA
    positive regulation of bone resorption GO:0045780 ISS
    positive regulation of alpha-beta T cell differentiation GO:0046638 IEA
    positive regulation of alpha-beta T cell proliferation GO:0046641 IEA
    blood vessel morphogenesis GO:0048514 ISS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    regulation of phagocytosis GO:0050764 ISS
    positive regulation of calcium-mediated signaling GO:0050850 IEA
    B cell receptor signaling pathway GO:0050853 IBA
    B cell receptor signaling pathway GO:0050853 IMP
    B cell receptor signaling pathway GO:0050853 ISS
    regulation of DNA-binding transcription factor activity GO:0051090 IMP
    regulation of ERK1 and ERK2 cascade GO:0070372 ISS
    cellular response to molecule of fungal origin GO:0071226 ISS
    cellular response to lipid GO:0071396 IMP
    cellular response to low-density lipoprotein particle stimulus GO:0071404 ISS
    positive regulation of monocyte chemotactic protein-1 production GO:0071639 IMP
    regulation of arachidonate secretion GO:0090237 ISS
    regulation of platelet aggregation GO:0090330 ISS
    apoptotic signaling pathway GO:0097190 IMP
    amyloid-beta clearance GO:0097242 IDA
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
    positive regulation of TORC1 signaling GO:1904263 IDA
    cellular response to amyloid-beta GO:1904646 IDA
    cellular response to lectin GO:1990858 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IC
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    B cell receptor complex GO:0019815 IEA
    early phagosome GO:0032009 ISS
    protein-containing complex GO:0032991 IDA
    T cell receptor complex GO:0042101 IDA
 Experiment description of studies that identified SYK in sEVs
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
3
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SYK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAIP  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 GRAP2 9402
Affinity Capture-MS Homo sapiens
3 HDAC4  
Reconstituted Complex Homo sapiens
4 HDAC2 3066
Reconstituted Complex Homo sapiens
5 PEAR1 375033
Affinity Capture-Western Homo sapiens
6 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 CD72  
Biochemical Activity Homo sapiens
8 BTF3 689
Affinity Capture-MS Homo sapiens
9 CD4 920
Affinity Capture-Western Homo sapiens
10 FCRL3  
Reconstituted Complex Homo sapiens
11 ABCF1 23
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 FCGR1A  
Co-localization Homo sapiens
13 TYROBP  
Reconstituted Complex Homo sapiens
14 CALM1 801
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
15 CD79A  
Reconstituted Complex Homo sapiens
16 RPS6KB2  
Biochemical Activity Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
18 FCGR2A 2212
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
19 FCGR3A  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
20 HDAC3 8841
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
21 PLCG2 5336
Affinity Capture-Western Homo sapiens
22 RHOU 58480
Reconstituted Complex Homo sapiens
23 TLR3  
Affinity Capture-Western Homo sapiens
24 HGS 9146
Biochemical Activity Homo sapiens
25 SRC 6714
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
26 STAT3 6774
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
27 PIK3CG  
Affinity Capture-Western Homo sapiens
28 SYK 6850
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
29 SIRPB1 10326
Affinity Capture-Western Homo sapiens
30 CD3E 916
Reconstituted Complex Homo sapiens
31 PLCG1 5335
Affinity Capture-Western Homo sapiens
32 Cbl 12402
Affinity Capture-Western Mus musculus
33 ITGA4 3676
Affinity Capture-MS Homo sapiens
34 EPOR  
Affinity Capture-Luminescence Homo sapiens
35 VCAM1 7412
Affinity Capture-MS Homo sapiens
36 ALCAM 214
Co-fractionation Homo sapiens
37 TUBA1A 7846
Biochemical Activity Homo sapiens
38 IL17RA 23765
Affinity Capture-Western Homo sapiens
39 CBLB 868
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
40 ERBB2 2064
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
41 NEDD4 4734
Reconstituted Complex Homo sapiens
42 TRIM15  
PCA Homo sapiens
43 ITGB3 3690
Affinity Capture-Western Homo sapiens
44 FCER1G 2207
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
45 KIT 3815
Reconstituted Complex Homo sapiens
46 VAV1 7409
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
47 COASY 80347
Biochemical Activity Homo sapiens
48 MS4A2  
Reconstituted Complex Homo sapiens
49 ERBB3 2065
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
50 RPS10 6204
Two-hybrid Homo sapiens
51 LYN 4067
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 CBL 867
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
53 PAG1 55824
Reconstituted Complex Homo sapiens
54 RPS6KB1 6198
Biochemical Activity Homo sapiens
55 UBASH3B 84959
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
56 MAPT  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
57 FYN 2534
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
58 SP1  
Affinity Capture-Western Homo sapiens
59 NEDD4L 23327
Affinity Capture-Western Homo sapiens
60 CRKL 1399
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
61 PTK2B 2185
Affinity Capture-Western Homo sapiens
62 PIK3R1 5295
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
63 BTK 695
Affinity Capture-Western Homo sapiens
64 SH3BP2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
65 ITGB2 3689
Affinity Capture-Western Homo sapiens
66 PTPRO 5800
Affinity Capture-Western Homo sapiens
67 CEBPA  
Protein-peptide Homo sapiens
68 HCLS1 3059
Co-localization Homo sapiens
69 ATG16L1 55054
Affinity Capture-MS Homo sapiens
70 LAT 27040
Biochemical Activity Homo sapiens
71 TUBB 203068
Affinity Capture-Western Homo sapiens
72 SLA  
Affinity Capture-Western Homo sapiens
73 CD22 933
Affinity Capture-Western Homo sapiens
74 PTPN6 5777
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
75 CD79B 974
Reconstituted Complex Homo sapiens
76 LCP2 3937
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
77 HDAC9  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
78 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
79 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
80 ERBB4 2066
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
81 CTTN 2017
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
82 PRKD1 5587
Affinity Capture-Western Homo sapiens
83 EGFR 1956
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
84 PTK2 5747
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
85 MAP3K7  
Affinity Capture-Western Homo sapiens
86 TRAF3 7187
Affinity Capture-Western Homo sapiens
87 KLRAP1  
Affinity Capture-Western Homo sapiens
88 GAB1  
Reconstituted Complex Homo sapiens
89 CSF3R  
Affinity Capture-Western Homo sapiens
90 MET 4233
Reconstituted Complex Homo sapiens
91 SIT1 27240
Affinity Capture-Western Homo sapiens
92 INPP5D 3635
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
93 TLR4  
Affinity Capture-Western Homo sapiens
94 CD19 930
Affinity Capture-Western Homo sapiens
95 TICAM1  
Affinity Capture-Western Homo sapiens
96 SLC4A1 6521
Biochemical Activity Homo sapiens
97 FGR 2268
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
98 NCK1 4690
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
99 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
100 TRAF3IP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
101 GRASP  
Affinity Capture-Western Homo sapiens
102 VAV2 7410
Two-hybrid Homo sapiens
103 BKRF1  
Affinity Capture-MS
104 GRB2 2885
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
105 USP25  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
106 TUBG1 7283
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
107 HDAC6 10013
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
108 SEC23B 10483
Affinity Capture-MS Homo sapiens
109 LCK 3932
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
110 FCER1A  
Affinity Capture-Western Homo sapiens
111 GRM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
112 SH2D2A  
Two-hybrid Homo sapiens
113 MEGF10 84466
Affinity Capture-Western Homo sapiens
114 TLR9  
Affinity Capture-Western Homo sapiens
115 TBK1 29110
Affinity Capture-Western Homo sapiens
116 TERF1 7013
Two-hybrid Homo sapiens
117 PXN 5829
Affinity Capture-Western Homo sapiens
118 MYD88 4615
Affinity Capture-Western Homo sapiens
119 PIK3R2 5296
Two-hybrid Homo sapiens
120 AR 367
Reconstituted Complex Homo sapiens
121 BLNK  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
122 EP300 2033
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SYK is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Anti-inflammatory response favouring Leishmania parasite infection TAS Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IEA Reactome
C-type lectin receptors (CLRs) IEA Reactome
C-type lectin receptors (CLRs) TAS Reactome
CLEC7A (Dectin-1) signaling IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
DAP12 interactions TAS Reactome
DAP12 signaling TAS Reactome
Dectin-2 family TAS Reactome
Dectin-2 family IEA Reactome
Disease TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
FCERI mediated Ca+2 mobilization TAS Reactome
FCERI mediated MAPK activation TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis IEA Reactome
FCGR activation TAS Reactome
FCGR activation IEA Reactome
FCGR3A-mediated IL10 synthesis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
FLT3 Signaling TAS Reactome
FLT3 signaling through SRC family kinases TAS Reactome
GPVI-mediated activation cascade TAS Reactome
GPVI-mediated activation cascade IEA Reactome
Hemostasis TAS Reactome
Hemostasis IEA Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Inactivation of CSF3 (G-CSF) signaling IEA Reactome
Inactivation of CSF3 (G-CSF) signaling TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Integrin signaling TAS Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-2 signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Leishmania infection TAS Reactome
Leishmania parasite growth and survival TAS Reactome
Leishmania phagocytosis TAS Reactome
Parasite infection TAS Reactome
Parasitic Infection Pathways TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet activation, signaling and aggregation IEA Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
Potential therapeutics for SARS TAS Reactome
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
Regulation of signaling by CBL IEA Reactome
Regulation of signaling by CBL TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization IEA Reactome
Role of phospholipids in phagocytosis TAS Reactome
SARS-CoV Infections TAS Reactome
Signal Transduction TAS Reactome
Signaling by CSF3 (G-CSF) IEA Reactome
Signaling by CSF3 (G-CSF) TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Viral Infection Pathways TAS Reactome





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