Gene description for CD22
Gene name CD22 molecule
Gene symbol CD22
Other names/aliases SIGLEC-2
SIGLEC2
Species Homo sapiens
 Database cross references - CD22
ExoCarta ExoCarta_933
Vesiclepedia VP_933
Entrez Gene 933
HGNC 1643
MIM 107266
UniProt P20273  
 CD22 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for CD22
Molecular Function
    carbohydrate binding GO:0030246 IEA
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 IEA
    external side of plasma membrane GO:0009897 IEA
 Experiment description of studies that identified CD22 in exosomes
1
Experiment ID 79
MISEV standards
EV Biophysical techniques
CD81|MHCII
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
EV Biophysical techniques
CD81|MHCII
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
EV Biophysical techniques
CD81|MHCII
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for CD22
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYN 4067
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
2 AP2M1 1173
Two-hybrid Homo sapiens
3 SYK 6850
Invitro Homo sapiens
4 HP 3240
Invivo Homo sapiens
5 INPP5D 3635
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 PLCG1 5335
Invitro Homo sapiens
7 GRB2 2885
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 SHC1 6464
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 PTPRC 5788
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
10 CD19 930
Invivo Homo sapiens
11 PTPN6 5777
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 AP2A1 160
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CD22 is involved
No pathways found





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