Gene description for CD22
Gene name
CD22 molecule
Gene symbol
CD22
Other names/aliases
SIGLEC-2 SIGLEC2
Species
Homo sapiens
Database cross references - CD22
ExoCarta
ExoCarta_933
Vesiclepedia
VP_933
Entrez Gene
933
HGNC
1643
MIM
107266
UniProt
P20273
CD22 identified in exosomes derived from the following tissue/cell type
B cells
20458337
B cells
20458337
B cells
20458337
Gene ontology annotations for CD22
Experiment description of studies that identified CD22 in exosomes
1
Experiment ID
79
MISEV standards
✘
EV Biophysical techniques
✔
CD81|MHCII
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
20458337
Organism
Homo sapiens
Experiment description
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name
ICB
Publication year
2010
Sample
B cells
Sample name
RN (HLA-DR15)
Isolation/purification methods
Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II)
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [FT-ICR] Western blotting
2
Experiment ID
80
MISEV standards
✘
EV Biophysical techniques
✔
CD81|MHCII
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
20458337
Organism
Homo sapiens
Experiment description
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name
ICB
Publication year
2010
Sample
B cells
Sample name
RN (HLA-DR15)
Isolation/purification methods
Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II)
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [FT-ICR] Western blotting
3
Experiment ID
81
MISEV standards
✘
EV Biophysical techniques
✔
CD81|MHCII
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
20458337
Organism
Homo sapiens
Experiment description
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name
ICB
Publication year
2010
Sample
B cells
Sample name
RN (HLA-DR15)
Isolation/purification methods
Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II)
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [FT-ICR] Western blotting
Protein-protein interactions for CD22
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
LYN
4067
Biochemical Activity
Homo sapiens
Affinity Capture-Western
Homo sapiens
2
AP2M1
1173
Two-hybrid
Homo sapiens
3
SYK
6850
Invitro
Homo sapiens
4
HP
3240
Invivo
Homo sapiens
5
INPP5D
3635
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
6
PLCG1
5335
Invitro
Homo sapiens
7
GRB2
2885
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
8
SHC1
6464
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
9
PTPRC
5788
Invivo
Homo sapiens
Affinity Capture-Western
Homo sapiens
10
CD19
930
Invivo
Homo sapiens
11
PTPN6
5777
Biochemical Activity
Homo sapiens
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
12
AP2A1
160
Affinity Capture-Western
Homo sapiens
View the network
image/svg+xml
Pathways in which CD22 is involved
No pathways found