Gene description for S100A7
Gene name S100 calcium binding protein A7
Gene symbol S100A7
Other names/aliases PSOR1
S100A7c
Species Homo sapiens
 Database cross references - S100A7
ExoCarta ExoCarta_6278
Entrez Gene 6278
HGNC 10497
MIM 600353
UniProt P31151  
 S100A7 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for S100A7
Molecular Function
    zinc ion binding GO:0008270 NAS
    protein binding GO:0005515 IPI
    RAGE receptor binding GO:0050786 IPI
    calcium ion binding GO:0005509 IDA
Biological Process
    positive regulation of T cell chemotaxis GO:0010820 IDA
    epidermis development GO:0008544 TAS
    response to lipopolysaccharide GO:0032496 IEP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    innate immune response GO:0045087 NAS
    angiogenesis GO:0001525 NAS
    response to reactive oxygen species GO:0000302 IDA
    positive regulation of monocyte chemotaxis GO:0090026 IDA
    keratinocyte differentiation GO:0030216 NAS
    defense response to Gram-negative bacterium GO:0050829 IMP
    positive regulation of granulocyte chemotaxis GO:0071624 IDA
    sequestering of metal ion GO:0051238 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    endoplasmic reticulum GO:0005783 IDA
    cytosol GO:0005829 IDA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 TAS
    focal adhesion GO:0005925 NAS
 Experiment description of studies that identified S100A7 in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for S100A7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RANBP9 10048
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 COPS5 10987
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
3 FABP5 2171
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
4 PAK7  
Affinity Capture-MS Homo sapiens
5 S100A7 6278
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which S100A7 is involved
No pathways found





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