Gene description for S100A7
Gene name S100 calcium binding protein A7
Gene symbol S100A7
Other names/aliases PSOR1
S100A7c
Species Homo sapiens
 Database cross references - S100A7
ExoCarta ExoCarta_6278
Vesiclepedia VP_6278
Entrez Gene 6278
HGNC 10497
MIM 600353
UniProt P31151  
 S100A7 identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for S100A7
Molecular Function
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 NAS
    calcium-dependent protein binding GO:0048306 IBA
    RAGE receptor binding GO:0050786 IPI
    zinc ion sequestering activity GO:0140486 IDA
Biological Process
    response to reactive oxygen species GO:0000302 IDA
    angiogenesis GO:0001525 NAS
    epidermis development GO:0008544 TAS
    positive regulation of T cell chemotaxis GO:0010820 IDA
    keratinocyte differentiation GO:0030216 NAS
    response to lipopolysaccharide GO:0032496 IEP
    endothelial cell migration GO:0043542 IBA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    positive regulation of granulocyte chemotaxis GO:0071624 IDA
    positive regulation of monocyte chemotaxis GO:0090026 IDA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 TAS
    endoplasmic reticulum GO:0005783 IDA
    cytosol GO:0005829 IDA
    focal adhesion GO:0005925 NAS
    azurophil granule lumen GO:0035578 TAS
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified S100A7 in sEVs
1
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for S100A7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RALY 22913
Affinity Capture-MS Homo sapiens
2 RPL26L1 51121
Affinity Capture-MS Homo sapiens
3 SERPINB4 6318
Affinity Capture-MS Homo sapiens
4 SHC1 6464
Affinity Capture-MS Homo sapiens
5 POT1  
Affinity Capture-MS Homo sapiens
6 ANXA2 302
Affinity Capture-MS Homo sapiens
7 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
8 RNF25 64320
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FBXL19  
Affinity Capture-MS Homo sapiens
10 ZNF354C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PLAC8L1  
Affinity Capture-MS Homo sapiens
13 ZNF674 641339
Affinity Capture-MS Homo sapiens
14 ST7  
Affinity Capture-MS Homo sapiens
15 CASP14 23581
Affinity Capture-MS Homo sapiens
16 EIF4E2  
Affinity Capture-MS Homo sapiens
17 COPS5 10987
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 B3GNT2 10678
Affinity Capture-MS Homo sapiens
19 FBXO44  
Affinity Capture-MS Homo sapiens
20 CA8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 FABP5 2171
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 GRK4  
Affinity Capture-MS Homo sapiens
23 NUDT3 11165
Affinity Capture-MS Homo sapiens
24 UCHL5 51377
Reconstituted Complex Homo sapiens
25 PHF11 51131
Affinity Capture-MS Homo sapiens
26 METTL23  
Affinity Capture-MS Homo sapiens
27 MYCN  
Affinity Capture-MS Homo sapiens
28 AGPAT1 10554
Affinity Capture-MS Homo sapiens
29 NEDD4 4734
Affinity Capture-MS Homo sapiens
30 C18orf21  
Affinity Capture-MS Homo sapiens
31 FAM20C 56975
Affinity Capture-MS Homo sapiens
32 CD22 933
Affinity Capture-MS Homo sapiens
33 DDX19B 11269
Affinity Capture-MS Homo sapiens
34 SETD8  
Affinity Capture-MS Homo sapiens
35 ZNF550  
Affinity Capture-MS Homo sapiens
36 PPIB 5479
Affinity Capture-MS Homo sapiens
37 GGPS1  
Affinity Capture-MS Homo sapiens
38 CUL4B 8450
Affinity Capture-MS Homo sapiens
39 TAOK1 57551
Affinity Capture-MS Homo sapiens
40 MMRN1 22915
Affinity Capture-MS Homo sapiens
41 FUNDC2 65991
Affinity Capture-MS Homo sapiens
42 RASSF9  
Affinity Capture-MS Homo sapiens
43 SFMBT1 51460
Affinity Capture-MS Homo sapiens
44 TRIM21 6737
Affinity Capture-MS Homo sapiens
45 SARAF  
Affinity Capture-MS Homo sapiens
46 PIGT 51604
Affinity Capture-MS Homo sapiens
47 S100A8 6279
Affinity Capture-MS Homo sapiens
48 WIPI1 55062
Affinity Capture-MS Homo sapiens
49 SSUH2  
Affinity Capture-MS Homo sapiens
50 MBD4  
Affinity Capture-MS Homo sapiens
51 PAK7  
Affinity Capture-MS Homo sapiens
52 UPK1A 11045
Affinity Capture-MS Homo sapiens
53 MRPL39 54148
Affinity Capture-MS Homo sapiens
54 DKK2  
Affinity Capture-MS Homo sapiens
55 FSTL1 11167
Affinity Capture-MS Homo sapiens
56 HIST1H2AI 8329
Affinity Capture-MS Homo sapiens
57 KCNIP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 MRM1  
Affinity Capture-MS Homo sapiens
59 RHBDD1 84236
Affinity Capture-MS Homo sapiens
60 SERPINB3 6317
Affinity Capture-MS Homo sapiens
61 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
62 NDST2  
Affinity Capture-MS Homo sapiens
63 FANCD2  
Affinity Capture-MS Homo sapiens
64 AIFM1 9131
Affinity Capture-MS Homo sapiens
65 CCNC  
Affinity Capture-MS Homo sapiens
66 DOCK8 81704
Affinity Capture-MS Homo sapiens
67 XPO1 7514
Affinity Capture-MS Homo sapiens
68 LMNB1 4001
Affinity Capture-MS Homo sapiens
69 C16orf70  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 FAM60A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
73 MECP2 4204
Affinity Capture-MS Homo sapiens
74 PDIA3 2923
Affinity Capture-MS Homo sapiens
75 EGFR 1956
Affinity Capture-MS Homo sapiens
76 MYC  
Affinity Capture-MS Homo sapiens
77 CREM  
Affinity Capture-MS Homo sapiens
78 SUSD3 203328
Affinity Capture-MS Homo sapiens
79 S100A7L2  
Two-hybrid Homo sapiens
80 RANBP9 10048
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
81 RPL36 25873
Affinity Capture-MS Homo sapiens
82 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
83 IFIT1 3434
Affinity Capture-MS Homo sapiens
84 RASSF10  
Affinity Capture-MS Homo sapiens
85 COA5  
Affinity Capture-MS Homo sapiens
86 RPL35A 6165
Affinity Capture-MS Homo sapiens
87 SYS1  
Affinity Capture-MS Homo sapiens
88 STK4 6789
Affinity Capture-MS Homo sapiens
89 MRPL38  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 RASSF7  
Affinity Capture-MS Homo sapiens
91 STX17 55014
Affinity Capture-MS Homo sapiens
92 RIPPLY3  
Affinity Capture-MS Homo sapiens
93 PRSS16 10279
Affinity Capture-MS Homo sapiens
94 TFG 10342
Affinity Capture-MS Homo sapiens
95 KIAA0907  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 STARD13 90627
Affinity Capture-MS Homo sapiens
97 TERF2  
Affinity Capture-MS Homo sapiens
98 MIP  
Affinity Capture-MS Homo sapiens
99 APTX  
Affinity Capture-MS Homo sapiens
100 SCGB1D1  
Affinity Capture-MS Homo sapiens
101 NMB  
Affinity Capture-MS Homo sapiens
102 SH2D3A  
Affinity Capture-MS Homo sapiens
103 CUL5 8065
Affinity Capture-MS Homo sapiens
104 EMC4 51234
Affinity Capture-MS Homo sapiens
105 ZNF154  
Affinity Capture-MS Homo sapiens
106 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 C1orf35  
Affinity Capture-MS Homo sapiens
108 TREX2  
Affinity Capture-MS Homo sapiens
109 PTDSS1 9791
Affinity Capture-MS Homo sapiens
110 ELMOD3  
Affinity Capture-MS Homo sapiens
111 S100A9 6280
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
112 MKI67  
Affinity Capture-MS Homo sapiens
113 CLVS2 134829
Two-hybrid Homo sapiens
114 HOXD10  
Affinity Capture-MS Homo sapiens
115 KLHL11  
Affinity Capture-MS Homo sapiens
116 ESR1  
Affinity Capture-MS Homo sapiens
117 ERCC3  
Affinity Capture-MS Homo sapiens
118 TERF1 7013
Affinity Capture-MS Homo sapiens
119 KIR3DS1  
Affinity Capture-MS Homo sapiens
120 ARHGAP36  
Affinity Capture-MS Homo sapiens
121 PMVK 10654
Affinity Capture-MS Homo sapiens
122 AIRE  
Affinity Capture-MS Homo sapiens
123 TSPAN6 7105
Affinity Capture-MS Homo sapiens
124 PINK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 RAB11A 8766
Affinity Capture-MS Homo sapiens
126 GOT1 2805
Affinity Capture-MS Homo sapiens
127 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 OR2A4 79541
Affinity Capture-MS Homo sapiens
129 TAOK2 9344
Affinity Capture-MS Homo sapiens
130 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
131 GABPA 2551
Affinity Capture-MS Homo sapiens
132 CCR1  
Affinity Capture-MS Homo sapiens
133 GUCY1A3  
Affinity Capture-MS Homo sapiens
134 CDK11A 728642
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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