Gene description for FSTL1
Gene name follistatin-like 1
Gene symbol FSTL1
Other names/aliases FRP
FSL1
MIR198
Species Homo sapiens
 Database cross references - FSTL1
ExoCarta ExoCarta_11167
Entrez Gene 11167
HGNC 3972
MIM 605547
UniProt Q12841  
 FSTL1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for FSTL1
Molecular Function
    heparin binding GO:0008201 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    BMP signaling pathway GO:0030509 TAS
    response to starvation GO:0042594 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified FSTL1 in exosomes
1
Experiment ID 226
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD9|FLOT1
EV Membrane markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
✘ EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for FSTL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FSTL1 is involved
PathwayEvidenceSource
Signaling by BMP TAS Reactome





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