Gene description for WNT5A
Gene name	wingless-type MMTV integration site family, member 5A
Gene symbol	WNT5A
Other names/aliases	hWNT5A
Species	Homo sapiens
Database cross references - WNT5A
ExoCarta	ExoCarta_7474
Entrez Gene	7474
HGNC	12784
MIM	164975
UniProt	P41221
WNT5A identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for WNT5A

Molecular Function     cytokine activity GO:0005125 IEA     frizzled binding GO:0005109 IPI     receptor tyrosine kinase-like orphan receptor binding GO:0005115 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 IMP     receptor agonist activity GO:0048018 IC     frizzled-2 binding GO:0005110 IEA     transcription regulatory region DNA binding GO:0044212 IDA     protein domain specific binding GO:0019904 IEA Biological Process     positive regulation of protein catabolic process GO:0045732 IGI     negative regulation of epithelial cell proliferation GO:0050680 IEA     urinary bladder development GO:0060157 IEA     response to organic substance GO:0010033 IEP     embryonic digit morphogenesis GO:0042733 IEA     positive regulation of thymocyte apoptotic process GO:0070245 IEA     keratinocyte differentiation GO:0030216 IEP     positive regulation of cell-cell adhesion mediated by cadherin GO:2000049 IEA     cellular response to lipopolysaccharide GO:0071222 IEP     positive regulation of inflammatory response GO:0050729 IMP     negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 IEA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     primitive streak formation GO:0090009 IEA     epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA     regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IEA     embryonic skeletal system development GO:0048706 IMP     type B pancreatic cell development GO:0003323 IEA     cochlea morphogenesis GO:0090103 IEA     positive regulation of type I interferon-mediated signaling pathway GO:0060340 IDA     planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 IEA     cellular response to transforming growth factor beta stimulus GO:0071560 IEP     male gonad development GO:0008584 IEP     cellular protein localization GO:0034613 IDA     cellular response to interferon-gamma GO:0071346 IEP     positive regulation of cartilage development GO:0061036 IEA     positive regulation of meiotic nuclear division GO:0045836 IEA     cellular response to calcium ion GO:0071277 IEP     positive regulation of mesenchymal cell proliferation GO:0002053 IEA     olfactory bulb interneuron development GO:0021891 ISS     positive regulation of macrophage activation GO:0043032 IMP     genitalia development GO:0048806 IMP     anterior/posterior axis specification, embryo GO:0008595 IEA     positive regulation of angiogenesis GO:0045766 IMP     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS     lung development GO:0030324 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     ameboidal-type cell migration GO:0001667 IEA     hypophysis morphogenesis GO:0048850 IEA     dopaminergic neuron differentiation GO:0071542 IEA     convergent extension involved in organogenesis GO:0060029 IEA     positive regulation of protein kinase C activity GO:1900020 IMP     establishment of planar polarity GO:0001736 IEA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA     negative regulation of fat cell differentiation GO:0045599 IMP     negative regulation of mesenchymal cell proliferation GO:0072201 IDA     vagina development GO:0060068 IEA     cervix development GO:0060067 IEA     hematopoietic stem cell proliferation GO:0071425 IDA     canonical Wnt signaling pathway GO:0060070 IEA     negative regulation of apoptotic process GO:0043066 IDA     positive regulation of cytokine secretion involved in immune response GO:0002741 IMP     hindgut morphogenesis GO:0007442 IEA     positive regulation of interleukin-8 secretion GO:2000484 IEA     post-anal tail morphogenesis GO:0036342 IEA     lens development in camera-type eye GO:0002088 ISS     positive regulation of ossification GO:0045778 IMP     mesenchymal-epithelial cell signaling GO:0060638 IEA     somitogenesis GO:0001756 IEA     neuron differentiation GO:0030182 ISS     optic cup formation involved in camera-type eye development GO:0003408 ISS     activation of JUN kinase activity GO:0007257 IMP     cellular response to retinoic acid GO:0071300 ISS     planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 IEA     positive regulation of interleukin-6 production GO:0032755 IMP     negative regulation of prostatic bud formation GO:0060686 IEA     negative regulation of synapse assembly GO:0051964 IEA     positive regulation of peptidyl-threonine phosphorylation GO:0010800 IEA     palate development GO:0060021 IMP     cartilage development GO:0051216 IEA     planar cell polarity pathway involved in neural tube closure GO:0090179 IEA     positive regulation of endothelial cell migration GO:0010595 IMP     positive regulation of fibroblast proliferation GO:0048146 IDA     positive regulation of response to cytokine stimulus GO:0060760 IDA     positive regulation of endothelial cell proliferation GO:0001938 IMP     uterus development GO:0060065 IEA     midgut development GO:0007494 IEA     epithelial to mesenchymal transition GO:0001837 IEP     negative regulation of axon extension involved in axon guidance GO:0048843 IEA     positive regulation of transcription, DNA-templated GO:0045893 IMP     Wnt signaling pathway GO:0016055 IDA     heart looping GO:0001947 IEA     Wnt signaling pathway, calcium modulating pathway GO:0007223 IMP     positive regulation of neuron projection development GO:0010976 ISS     negative regulation of BMP signaling pathway GO:0030514 IEA     face development GO:0060324 IMP     lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 IEA     mammary gland branching involved in thelarche GO:0060744 IEA     positive regulation of chemokine biosynthetic process GO:0045080 IMP     positive regulation of macrophage cytokine production GO:0060907 IMP     positive regulation of interferon-gamma production GO:0032729 IEA     activation of MAPK activity GO:0000187 IDA     activation of protein kinase B activity GO:0032148 IDA     negative chemotaxis GO:0050919 IEA     positive regulation of T cell chemotaxis GO:0010820 IMP     negative regulation of transcription, DNA-templated GO:0045892 IDA     cell fate commitment GO:0045165 IBA     positive regulation of protein kinase C signaling GO:0090037 IMP     planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 IEA     planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 IEA     positive regulation of cGMP metabolic process GO:0030825 IDA     planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 IEA     wound healing GO:0042060 IDA     axon guidance GO:0007411 ISS     positive regulation of interleukin-1 beta secretion GO:0050718 IMP     non-canonical Wnt signaling pathway via JNK cascade GO:0038031 IEA Subcellular Localization     cell surface GO:0009986 IEA     extracellular region GO:0005576 TAS     clathrin-coated endocytic vesicle membrane GO:0030669 TAS     endoplasmic reticulum lumen GO:0005788 TAS     proteinaceous extracellular matrix GO:0005578 IEA     extracellular space GO:0005615 IDA     Golgi lumen GO:0005796 TAS     extracellular exosome GO:0070062 TAS     plasma membrane GO:0005886 TAS