Gene description for FZD1
Gene name frizzled class receptor 1
Gene symbol FZD1
Other names/aliases -
Species Homo sapiens
 Database cross references - FZD1
ExoCarta ExoCarta_8321
Vesiclepedia VP_8321
Entrez Gene 8321
HGNC 4038
MIM 603408
UniProt Q9UP38  
 FZD1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for FZD1
Molecular Function
    G protein-coupled receptor activity GO:0004930 IEA
    signaling receptor binding GO:0005102 IPI
    frizzled binding GO:0005109 IPI
    protein binding GO:0005515 IPI
    Wnt-protein binding GO:0017147 IBA
    Wnt-protein binding GO:0017147 IPI
    Wnt-protein binding GO:0017147 NAS
    PDZ domain binding GO:0030165 IPI
    Wnt receptor activity GO:0042813 IBA
    Wnt receptor activity GO:0042813 IDA
    Wnt receptor activity GO:0042813 NAS
    Wnt receptor activity GO:0042813 TAS
Biological Process
    membranous septum morphogenesis GO:0003149 IEA
    muscular septum morphogenesis GO:0003150 IEA
    outflow tract morphogenesis GO:0003151 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    cell-cell signaling GO:0007267 IDA
    response to xenobiotic stimulus GO:0009410 IMP
    positive regulation of neuron projection development GO:0010976 ISS
    neuron differentiation GO:0030182 ISS
    negative regulation of BMP signaling pathway GO:0030514 IEA
    autocrine signaling GO:0035425 IDA
    non-canonical Wnt signaling pathway GO:0035567 IBA
    astrocyte-dopaminergic neuron signaling GO:0036520 IEA
    endothelial cell differentiation GO:0045446 IEA
    positive regulation of osteoblast differentiation GO:0045669 IMP
    negative regulation of DNA-templated transcription GO:0045892 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    hard palate development GO:0060022 IEA
    canonical Wnt signaling pathway GO:0060070 IBA
    canonical Wnt signaling pathway GO:0060070 IDA
    canonical Wnt signaling pathway GO:0060070 IGI
    canonical Wnt signaling pathway GO:0060070 IMP
    canonical Wnt signaling pathway GO:0060070 NAS
    negative regulation of canonical Wnt signaling pathway GO:0090090 IEA
    presynapse assembly GO:0099054 TAS
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 IEA
    midbrain dopaminergic neuron differentiation GO:1904948 NAS
    regulation of presynapse assembly GO:1905606 IEA
    regulation of mesenchymal stem cell differentiation GO:2000739 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 HDA
    cell surface GO:0009986 IDA
    Wnt signalosome GO:1990909 IC
 Experiment description of studies that identified FZD1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for FZD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP5B 506
Affinity Capture-MS Homo sapiens
2 GOLGA2 2801
Affinity Capture-MS Homo sapiens
3 GSK3B 2932
Co-fractionation Homo sapiens
4 Hsf1  
Affinity Capture-MS Mus musculus
5 RBM26 64062
Affinity Capture-MS Homo sapiens
6 UPK1A 11045
Affinity Capture-MS Homo sapiens
7 MKRN2 23609
Affinity Capture-RNA Homo sapiens
8 DERL2 51009
Affinity Capture-MS Homo sapiens
9 Mis12  
Affinity Capture-MS Mus musculus
10 DLG4  
Two-hybrid Homo sapiens
11 SCGB1C1  
Affinity Capture-MS Homo sapiens
12 WNT3A 89780
Affinity Capture-Western Homo sapiens
13 WNT5A 7474
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here