Gene description for DERL2
Gene name derlin 2
Gene symbol DERL2
Other names/aliases CGI-101
DERtrin-2
F-LAN-1
F-LANa
FLANa
Species Homo sapiens
 Database cross references - DERL2
ExoCarta ExoCarta_51009
Vesiclepedia VP_51009
Entrez Gene 51009
HGNC 17943
MIM 610304
UniProt Q9GZP9  
 DERL2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DERL2
Molecular Function
    signal recognition particle binding GO:0005047 IBA
    signal recognition particle binding GO:0005047 IDA
    protein binding GO:0005515 IPI
    protein-containing complex binding GO:0044877 IPI
Biological Process
    suckling behavior GO:0001967 IEA
    positive regulation of cell population proliferation GO:0008284 IDA
    positive regulation of cell growth GO:0030307 IDA
    endoplasmic reticulum unfolded protein response GO:0030968 IBA
    endoplasmic reticulum unfolded protein response GO:0030968 IDA
    retrograde protein transport, ER to cytosol GO:0030970 IMP
    ERAD pathway GO:0036503 IBA
    ERAD pathway GO:0036503 IMP
    negative regulation of retrograde protein transport, ER to cytosol GO:1904153 IMP
Subcellular Localization
    early endosome GO:0005769 IEA
    late endosome GO:0005770 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified DERL2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DERL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDHA1 5160
Affinity Capture-MS Homo sapiens
2 GPM6A 2823
Affinity Capture-MS Homo sapiens
3 POR 5447
Affinity Capture-MS Homo sapiens
4 SNX3 8724
Affinity Capture-MS Homo sapiens
5 STT3A 3703
Affinity Capture-MS Homo sapiens
6 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
7 ADSL 158
Affinity Capture-MS Homo sapiens
8 TMEM184A  
Affinity Capture-MS Homo sapiens
9 Hspa14 50497
Affinity Capture-MS Mus musculus
10 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
11 PTPN1 5770
Affinity Capture-MS Homo sapiens
12 SYVN1 84447
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 RTN4 57142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MASTL  
Affinity Capture-MS Homo sapiens
15 Kcnk1  
Affinity Capture-MS Mus musculus
16 P2RY1  
Affinity Capture-MS Homo sapiens
17 FCN3 8547
Affinity Capture-MS Homo sapiens
18 HEY1  
Affinity Capture-Western Homo sapiens
19 SEL1L 6400
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
20 SLC6A5  
Affinity Capture-MS Homo sapiens
21 TMEM129  
Affinity Capture-Western Homo sapiens
22 RTN1 6252
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CCDC47 57003
Affinity Capture-MS Homo sapiens
24 SERPINA1 5265
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 NAT8B  
Affinity Capture-MS Homo sapiens
26 FAF2 23197
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
27 TMEM63B 55362
Affinity Capture-MS Homo sapiens
28 VIMP 55829
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
29 KCNK1  
Affinity Capture-MS Homo sapiens
30 RAB14 51552
Affinity Capture-MS Homo sapiens
31 IFITM3 10410
Affinity Capture-MS Homo sapiens
32 AMFR 267
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
33 P2RY8  
Affinity Capture-MS Homo sapiens
34 HEY2  
Affinity Capture-Western Homo sapiens
35 BAG6 7917
Affinity Capture-Western Homo sapiens
36 GPR35  
Affinity Capture-MS Homo sapiens
37 C12orf49  
Negative Genetic Homo sapiens
38 RAP1B 5908
Affinity Capture-MS Homo sapiens
39 VCP 7415
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
40 SARAF  
Affinity Capture-Western Homo sapiens
41 GPR182  
Affinity Capture-MS Homo sapiens
42 CUL2 8453
Affinity Capture-MS Homo sapiens
43 FAM49B 51571
Affinity Capture-MS Homo sapiens
44 GPR173  
Affinity Capture-MS Homo sapiens
45 HERPUD1  
Affinity Capture-Western Homo sapiens
46 KRTAP10-7  
Two-hybrid Homo sapiens
47 REEP5 7905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SNX1 6642
Affinity Capture-MS Homo sapiens
49 MGARP  
Affinity Capture-MS Homo sapiens
50 APLNR  
Affinity Capture-MS Homo sapiens
51 EMC3 55831
Affinity Capture-MS Homo sapiens
52 RPN2 6185
Affinity Capture-MS Homo sapiens
53 ERLEC1 27248
Affinity Capture-MS Homo sapiens
54 RAB5A 5868
Affinity Capture-MS Homo sapiens
55 TNFSF8  
Affinity Capture-MS Homo sapiens
56 KRTAP10-8  
Two-hybrid Homo sapiens
57 CRELD1 78987
Affinity Capture-MS Homo sapiens
58 P2RY2 5029
Affinity Capture-MS Homo sapiens
59 CUL3 8452
Affinity Capture-MS Homo sapiens
60 NR3C1 2908
Proximity Label-MS Homo sapiens
61 FZD1 8321
Affinity Capture-MS Homo sapiens
62 HTR2C  
Affinity Capture-MS Homo sapiens
63 KRTAP10-3  
Two-hybrid Homo sapiens
64 LPAR1 1902
Affinity Capture-MS Homo sapiens
65 FAM134C 162427
Affinity Capture-MS Homo sapiens
66 EMC2 9694
Affinity Capture-MS Homo sapiens
67 ACKR2  
Affinity Capture-MS Homo sapiens
68 Kctd5  
Affinity Capture-MS Mus musculus
69 SLC22A4 6583
Affinity Capture-MS Homo sapiens
70 FFAR1  
Affinity Capture-MS Homo sapiens
71 NCAPG 64151
Affinity Capture-MS Homo sapiens
72 UBE2J1 51465
Affinity Capture-Western Homo sapiens
73 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
74 FASN 2194
Negative Genetic Homo sapiens
75 UBXN4 23190
Affinity Capture-MS Homo sapiens
76 ATP5J 522
Affinity Capture-MS Homo sapiens
77 EXOC8 149371
Affinity Capture-MS Homo sapiens
78 OPALIN  
Affinity Capture-MS Homo sapiens
79 MFSD4  
Affinity Capture-MS Homo sapiens
80 EMC1 23065
Affinity Capture-MS Homo sapiens
81 CLEC2D  
Affinity Capture-MS Homo sapiens
82 RTN3 10313
Affinity Capture-MS Homo sapiens
83 EDEM1  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
84 TSPAN15 23555
Affinity Capture-MS Homo sapiens
85 B4GAT1 11041
Affinity Capture-MS Homo sapiens
86 HDAC1 3065
Affinity Capture-MS Homo sapiens
87 VTA1 51534
Affinity Capture-MS Homo sapiens
88 OS9 10956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
89 AARSD1 80755
Affinity Capture-MS Homo sapiens
90 Smn1 20595
Affinity Capture-MS Mus musculus
91 SHH  
Affinity Capture-Western Homo sapiens
92 TBRG4 9238
Affinity Capture-MS Homo sapiens
93 GP5 2814
Affinity Capture-MS Homo sapiens
94 LPAR2 9170
Affinity Capture-MS Homo sapiens
95 VIPR1  
Affinity Capture-MS Homo sapiens
96 CCR6  
Affinity Capture-MS Homo sapiens
97 S1PR4  
Affinity Capture-MS Homo sapiens
98 ESYT1 23344
Affinity Capture-MS Homo sapiens
99 FPR2  
Affinity Capture-MS Homo sapiens
100 DERL1 79139
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here