Gene description for RTN1
Gene name reticulon 1
Gene symbol RTN1
Other names/aliases NSP
Species Homo sapiens
 Database cross references - RTN1
ExoCarta ExoCarta_6252
Vesiclepedia VP_6252
Entrez Gene 6252
HGNC 10467
MIM 600865
UniProt Q16799  
 RTN1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RTN1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    brain development GO:0007420 IBA
    neuron differentiation GO:0030182 IBA
    neuron differentiation GO:0030182 IEP
    endoplasmic reticulum tubular network formation GO:0071787 IBA
    negative regulation of amyloid-beta formation GO:1902430 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    postsynaptic density GO:0014069 IBA
    dendrite GO:0030425 IEA
    neuron projection GO:0043005 IBA
    neuronal cell body GO:0043025 IEA
 Experiment description of studies that identified RTN1 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RTN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UTP18  
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 NDRG1 10397
Two-hybrid Homo sapiens
4 DERL2 51009
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DHCR24 1718
Affinity Capture-MS Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RAB9A 9367
Proximity Label-MS Homo sapiens
8 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
9 CCR4 1233
Two-hybrid Homo sapiens
10 ADRB2  
Two-hybrid Homo sapiens
11 PLEKHF2 79666
Two-hybrid Homo sapiens
12 HNRNPC 3183
Affinity Capture-MS Homo sapiens
13 PTPN1 5770
Proximity Label-MS Homo sapiens
14 STX4 6810
Proximity Label-MS Homo sapiens
15 RTN4 57142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SERPINE2 5270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 RDX 5962
Proximity Label-MS Homo sapiens
18 VARS 7407
Co-fractionation Homo sapiens
19 RAB3B 5865
Proximity Label-MS Homo sapiens
20 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SSR1 6745
Proximity Label-MS Homo sapiens
22 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
23 WDR3  
Affinity Capture-MS Homo sapiens
24 TOMM40 10452
Affinity Capture-MS Homo sapiens
25 F2RL1  
Two-hybrid Homo sapiens
26 SDCBP 6386
Two-hybrid Homo sapiens
27 FGFR1 2260
Two-hybrid Homo sapiens
28 HIST2H4A 8370
Affinity Capture-MS Homo sapiens
29 PRNP 5621
Affinity Capture-MS Homo sapiens
30 NUP155 9631
Proximity Label-MS Homo sapiens
31 KIAA1715 80856
Proximity Label-MS Homo sapiens
32 PXMP2  
Proximity Label-MS Homo sapiens
33 RAB5A 5868
Proximity Label-MS Homo sapiens
34 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
35 PLSCR1 5359
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 EMD 2010
Proximity Label-MS Homo sapiens
37 IFITM3 10410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 AMFR 267
Affinity Capture-MS Homo sapiens
39 NOL11  
Affinity Capture-MS Homo sapiens
40 TMEM43 79188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 RAP1B 5908
Affinity Capture-MS Homo sapiens
42 SCAMP2 10066
Affinity Capture-MS Homo sapiens
43 H2AFY 9555
Affinity Capture-MS Homo sapiens
44 DNTTIP2  
Affinity Capture-MS Homo sapiens
45 SEC61B 10952
Proximity Label-MS Homo sapiens
46 UTP15 84135
Affinity Capture-MS Homo sapiens
47 REEP5 7905
Proximity Label-MS Homo sapiens
48 C4orf32  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 LRRC59 55379
Proximity Label-MS Homo sapiens
50 TYMS 7298
Affinity Capture-MS Homo sapiens
51 SMARCA5 8467
Affinity Capture-MS Homo sapiens
52 LETM1 3954
Affinity Capture-MS Homo sapiens
53 BCAP31 10134
Proximity Label-MS Homo sapiens
54 HSD3B7 80270
Proximity Label-MS Homo sapiens
55 RTN2 6253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 DES 1674
Affinity Capture-MS Homo sapiens
57 STIM1 6786
Proximity Label-MS Homo sapiens
58 SLC7A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 BLK 640
Affinity Capture-MS Homo sapiens
60 ATP2A1 487
Proximity Label-MS Homo sapiens
61 CHRM5  
Two-hybrid Homo sapiens
62 DYRK2 8445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 GYPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 FAM213A 84293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 SUPT16H 11198
Affinity Capture-MS Homo sapiens
66 DRD2  
Two-hybrid Homo sapiens
67 FAM160A2 84067
Two-hybrid Homo sapiens
68 RTN3 10313
Affinity Capture-MS Homo sapiens
69 EZR 7430
Proximity Label-MS Homo sapiens
70 TMEM120B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 UGCG 7357
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
72 TBL3 10607
Affinity Capture-MS Homo sapiens
73 ELOVL5 60481
Proximity Label-MS Homo sapiens
74 HDAC8 55869
FRET Homo sapiens
75 TMEM70  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 NOC2L 26155
Affinity Capture-MS Homo sapiens
77 NRAS 4893
Affinity Capture-MS Homo sapiens
78 BCL2L1 598
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
79 SEC62 7095
Proximity Label-MS Homo sapiens
80 RAB7A 7879
Proximity Label-MS Homo sapiens
81 CYB5R3 1727
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 CKAP4 10970
Proximity Label-MS Homo sapiens
83 SSRP1 6749
Affinity Capture-MS Homo sapiens
84 EMG1 10436
Affinity Capture-MS Homo sapiens
85 FAM210B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RTN1 is involved
No pathways found





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