Gene description for NOC2L
Gene name nucleolar complex associated 2 homolog (S. cerevisiae)
Gene symbol NOC2L
Other names/aliases NET15
NET7
NIR
PPP1R112
Species Homo sapiens
 Database cross references - NOC2L
ExoCarta ExoCarta_26155
Vesiclepedia VP_26155
Entrez Gene 26155
HGNC 24517
MIM 610770
UniProt Q9Y3T9  
 NOC2L identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for NOC2L
Molecular Function
    histone binding GO:0042393 IDA
    nucleosome binding GO:0031491 IDA
    repressing transcription factor binding GO:0070491 IDA
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    transcription corepressor activity GO:0003714 IDA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IMP
    cellular response to UV GO:0034644 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    apoptotic process GO:0006915 IEA
    chromatin assembly GO:0031497 IDA
    nucleolus to nucleoplasm transport GO:0032066 IDA
    negative regulation of histone acetylation GO:0035067 IDA
    negative regulation of B cell apoptotic process GO:0002903 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified NOC2L in exosomes
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NOC2L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIF1  
Two-hybrid Homo sapiens
2 ILK 3611
Affinity Capture-MS Homo sapiens
3 BRF2  
Affinity Capture-MS Homo sapiens
4 PPP1CA 5499
Reconstituted Complex Homo sapiens
5 MAGED1 9500
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NOC2L is involved
No pathways found





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