Gene description for NOG
Gene name noggin
Gene symbol NOG
Other names/aliases SYM1
SYNS1
Species Homo sapiens
 Database cross references - NOG
ExoCarta ExoCarta_9241
Vesiclepedia VP_9241
Entrez Gene 9241
HGNC 7866
MIM 602991
UniProt Q13253  
 NOG identified in exosomes derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for NOG
Molecular Function
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IDA
    cytokine binding GO:0019955 IPI
Biological Process
    BMP signaling pathway GO:0030509 TAS
    positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 ISS
    neural plate morphogenesis GO:0001839 IEA
    prostatic bud formation GO:0060513 IEA
    embryonic skeletal joint morphogenesis GO:0060272 IMP
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    pituitary gland development GO:0021983 IEA
    skeletal system development GO:0001501 TAS
    lung morphogenesis GO:0060425 IEA
    positive regulation of glomerulus development GO:0090193 ISS
    fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation GO:0060825 IMP
    notochord morphogenesis GO:0048570 IEA
    endoderm formation GO:0001706 IEA
    mesoderm formation GO:0001707 IEA
    embryonic skeletal system development GO:0048706 IMP
    embryonic digit morphogenesis GO:0042733 IMP
    negative regulation of pathway-restricted SMAD protein phosphorylation GO:0060394 IDA
    negative regulation of osteoblast differentiation GO:0045668 IDA
    cell differentiation in hindbrain GO:0021533 IMP
    negative regulation of cartilage development GO:0061037 IEA
    negative regulation of BMP signaling pathway GO:0030514 ISS
    face morphogenesis GO:0060325 IEA
    osteoblast differentiation GO:0001649 ISS
    negative regulation of cytokine activity GO:0060302 IPI
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    wound healing GO:0042060 ISS
    in utero embryonic development GO:0001701 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    motor neuron axon guidance GO:0008045 IEA
    axial mesoderm development GO:0048318 IEA
    ureteric bud formation GO:0060676 IEA
    negative regulation of astrocyte differentiation GO:0048712 ISS
    cartilage development GO:0051216 IEA
    negative regulation of cell migration GO:0030336 IDA
    negative regulation of apoptotic signaling pathway GO:2001234 IEA
    nervous system development GO:0007399 TAS
    cellular response to BMP stimulus GO:0071773 IEA
    regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation GO:2000313 IMP
    neural tube closure GO:0001843 IEA
    epithelial to mesenchymal transition GO:0001837 ISS
    middle ear morphogenesis GO:0042474 IMP
    negative regulation of cardiac muscle cell proliferation GO:0060044 ISS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    somite development GO:0061053 IEA
    dorsal/ventral pattern formation GO:0009953 IDA
    somatic stem cell maintenance GO:0035019 IMP
    spinal cord development GO:0021510 IEA
    limb development GO:0060173 IMP
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified NOG in exosomes
1
Experiment ID 363
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for NOG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NOG 9241
Co-purification Homo sapiens
Co-purification Homo sapiens
2 BMP7 655
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
3 BMP4 652
Invivo Homo sapiens
4 BMP2  
Invivo Homo sapiens
5 BMP5 653
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which NOG is involved
PathwayEvidenceSource
Signaling by BMP TAS Reactome





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