Gene description for NOG
Gene name noggin
Gene symbol NOG
Other names/aliases SYM1
SYNS1
Species Homo sapiens
 Database cross references - NOG
ExoCarta ExoCarta_9241
Vesiclepedia VP_9241
Entrez Gene 9241
HGNC 7866
MIM 602991
UniProt Q13253  
 NOG identified in exosomes derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for NOG
Molecular Function
    protein binding GO:0005515 IPI
    cytokine binding GO:0019955 IPI
    protein homodimerization activity GO:0042803 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    skeletal system development GO:0001501 TAS
    osteoblast differentiation GO:0001649 IBA
    osteoblast differentiation GO:0001649 ISS
    in utero embryonic development GO:0001701 IEA
    endoderm formation GO:0001706 IEA
    mesoderm formation GO:0001707 IEA
    epithelial to mesenchymal transition GO:0001837 ISS
    neural plate morphogenesis GO:0001839 IEA
    neural tube closure GO:0001843 IEA
    membranous septum morphogenesis GO:0003149 ISS
    outflow tract morphogenesis GO:0003151 ISS
    ventricular compact myocardium morphogenesis GO:0003223 ISS
    endocardial cushion formation GO:0003272 ISS
    smoothened signaling pathway GO:0007224 IEA
    nervous system development GO:0007399 TAS
    motor neuron axon guidance GO:0008045 IEA
    visual learning GO:0008542 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    dorsal/ventral pattern formation GO:0009953 IBA
    dorsal/ventral pattern formation GO:0009953 IDA
    positive regulation of gene expression GO:0010628 ISS
    negative regulation of gene expression GO:0010629 IEA
    spinal cord development GO:0021510 IEA
    cell differentiation in hindbrain GO:0021533 IMP
    pituitary gland development GO:0021983 IEA
    neural plate anterior/posterior regionalization GO:0021999 IMP
    negative regulation of cell migration GO:0030336 IDA
    BMP signaling pathway GO:0030509 IEA
    negative regulation of BMP signaling pathway GO:0030514 IBA
    negative regulation of BMP signaling pathway GO:0030514 IDA
    negative regulation of BMP signaling pathway GO:0030514 ISS
    somatic stem cell population maintenance GO:0035019 IMP
    exploration behavior GO:0035640 IEA
    nodal signaling pathway GO:0038092 IMP
    regulation of fibroblast growth factor receptor signaling pathway GO:0040036 IMP
    wound healing GO:0042060 ISS
    middle ear morphogenesis GO:0042474 IMP
    embryonic digit morphogenesis GO:0042733 IMP
    negative regulation of osteoblast differentiation GO:0045668 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    regulation of neuronal synaptic plasticity GO:0048168 IEA
    axial mesoderm development GO:0048318 IEA
    notochord morphogenesis GO:0048570 IEA
    embryonic skeletal system development GO:0048706 IMP
    negative regulation of astrocyte differentiation GO:0048712 ISS
    stem cell differentiation GO:0048863 IEA
    epithelial cell proliferation GO:0050673 IEA
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    cartilage development GO:0051216 IEA
    atrial cardiac muscle tissue morphogenesis GO:0055009 ISS
    negative regulation of cardiac muscle cell proliferation GO:0060044 ISS
    limb development GO:0060173 IMP
    embryonic skeletal joint morphogenesis GO:0060272 IMP
    long-term synaptic potentiation GO:0060291 IEA
    negative regulation of cytokine activity GO:0060302 IDA
    face morphogenesis GO:0060325 IEA
    negative regulation of SMAD protein signal transduction GO:0060392 IDA
    ventricular septum morphogenesis GO:0060412 ISS
    lung morphogenesis GO:0060425 IEA
    prostatic bud formation GO:0060513 IEA
    ureteric bud formation GO:0060676 IEA
    negative regulation of cartilage development GO:0061037 IEA
    somite development GO:0061053 IEA
    heart trabecula morphogenesis GO:0061384 ISS
    pharyngeal arch artery morphogenesis GO:0061626 ISS
    negative regulation of cardiac epithelial to mesenchymal transition GO:0062044 ISS
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 ISS
    positive regulation of glomerulus development GO:0090193 ISS
    presynaptic modulation of chemical synaptic transmission GO:0099171 IEA
    cranial skeletal system development GO:1904888 IEA
    short-term synaptic potentiation GO:1990926 IEA
    negative regulation of apoptotic signaling pathway GO:2001234 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified NOG in exosomes
1
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for NOG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL9 55958
Affinity Capture-MS Homo sapiens
2 UBR2 23304
Affinity Capture-MS Homo sapiens
3 CENPB 1059
Affinity Capture-MS Homo sapiens
4 KBTBD7  
Affinity Capture-MS Homo sapiens
5 CALR 811
Affinity Capture-MS Homo sapiens
6 ZNF22  
Affinity Capture-MS Homo sapiens
7 ASCC3 10973
Affinity Capture-MS Homo sapiens
8 SULF1 23213
Affinity Capture-MS Homo sapiens
9 KBTBD6  
Affinity Capture-MS Homo sapiens
10 TOR3A 64222
Affinity Capture-MS Homo sapiens
11 PNN 5411
Affinity Capture-MS Homo sapiens
12 VGF  
Affinity Capture-MS Homo sapiens
13 LARP1B 55132
Affinity Capture-MS Homo sapiens
14 NAP1L3  
Affinity Capture-MS Homo sapiens
15 BRD2  
Affinity Capture-MS Homo sapiens
16 ITIH2 3698
Affinity Capture-MS Homo sapiens
17 FARP2 9855
Affinity Capture-MS Homo sapiens
18 PDCD11 22984
Affinity Capture-MS Homo sapiens
19 KLHL13 90293
Affinity Capture-MS Homo sapiens
20 APLP2 334
Affinity Capture-MS Homo sapiens
21 VWDE  
Affinity Capture-MS Homo sapiens
22 NOC2L 26155
Affinity Capture-MS Homo sapiens
23 TRMT1L 81627
Affinity Capture-MS Homo sapiens
24 RPS13 6207
Affinity Capture-MS Homo sapiens
25 TRIP4 9325
Affinity Capture-MS Homo sapiens
26 FAM115C  
Affinity Capture-MS Homo sapiens
27 GPC3 2719
Affinity Capture-MS Homo sapiens
28 BMP7 655
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
29 MRPS16  
Affinity Capture-MS Homo sapiens
30 DICER1  
Affinity Capture-MS Homo sapiens
31 ASCC2 84164
Affinity Capture-MS Homo sapiens
32 UBTF 7343
Affinity Capture-MS Homo sapiens
33 KRAS 3845
Synthetic Lethality Homo sapiens
34 SRRM2 23524
Affinity Capture-MS Homo sapiens
35 NOG 9241
Co-purification Homo sapiens
Co-purification Homo sapiens
36 QTRT1 81890
Affinity Capture-MS Homo sapiens
37 AMER1  
Affinity Capture-MS Homo sapiens
38 CSPG5 10675
Affinity Capture-MS Homo sapiens
39 ZCCHC3  
Affinity Capture-MS Homo sapiens
40 HTRA1 5654
Affinity Capture-MS Homo sapiens
41 RPS16 6217
Affinity Capture-MS Homo sapiens
42 CEBPZ  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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