Gene description for BMP7
Gene name	bone morphogenetic protein 7
Gene symbol	BMP7
Other names/aliases	OP-1
Species	Homo sapiens
Database cross references - BMP7
ExoCarta	ExoCarta_655
Entrez Gene	655
HGNC	1074
MIM	112267
UniProt	P18075
BMP7 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells	25844599
Prostate cancer cells	25844599

Gene ontology annotations for BMP7

Molecular Function     BMP receptor binding GO:0070700 IBA     growth factor activity GO:0008083 IEA     protein binding GO:0005515 IPI     transforming growth factor beta receptor binding GO:0005160 IBA     cytokine activity GO:0005125 IBA     heparin binding GO:0008201 IEA Biological Process     negative regulation of striated muscle cell apoptotic process GO:0010664 ISS     positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 TAS     epithelial to mesenchymal transition GO:0001837 TAS     positive regulation of dendrite development GO:1900006 IDA     steroid hormone mediated signaling pathway GO:0043401 IMP     regulation of pathway-restricted SMAD protein phosphorylation GO:0060393 IDA     axon guidance GO:0007411 IEA     metanephros development GO:0001656 IEP     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     positive regulation of bone mineralization GO:0030501 IDA     positive regulation of apoptotic process GO:0043065 IEA     positive regulation of transcription, DNA-templated GO:0045893 IDA     growth GO:0040007 IEA     regulation of branching involved in prostate gland morphogenesis GO:0060687 IEA     branching involved in salivary gland morphogenesis GO:0060445 IEA     metanephric mesenchyme morphogenesis GO:0072133 IEA     negative regulation of cell cycle GO:0045786 IDA     mesoderm formation GO:0001707 IEA     cell development GO:0048468 IBA     cellular response to hypoxia GO:0071456 ISS     positive regulation of peptidyl-threonine phosphorylation GO:0010800 IDA     odontogenesis of dentin-containing tooth GO:0042475 IEA     embryonic limb morphogenesis GO:0030326 IEA     negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072040 IEA     ureteric bud development GO:0001657 ISS     negative regulation of transcription, DNA-templated GO:0045892 IDA     embryonic skeletal joint morphogenesis GO:0060272 IEA     monocyte aggregation GO:0070487 IDA     regulation of apoptotic process GO:0042981 IBA     nephrogenic mesenchyme morphogenesis GO:0072134 IEA     dendrite development GO:0016358 TAS     negative regulation of phosphorylation GO:0042326 IDA     negative regulation of MAP kinase activity GO:0043407 IDA     negative regulation of prostatic bud formation GO:0060686 IEA     negative regulation of Notch signaling pathway GO:0045746 IEA     embryonic pattern specification GO:0009880 IEA     negative regulation of neuron differentiation GO:0045665 IDA     response to estradiol GO:0032355 IEA     negative regulation of NF-kappaB transcription factor activity GO:0032088 ISS     response to peptide hormone GO:0043434 IEA     positive regulation of hyaluranon cable assembly GO:1900106 IDA     negative regulation of NF-kappaB import into nucleus GO:0042347 ISS     response to vitamin D GO:0033280 IEA     BMP signaling pathway GO:0030509 IDA     positive regulation of heterotypic cell-cell adhesion GO:0034116 IDA     positive regulation of osteoblast differentiation GO:0045669 IDA     mesonephros development GO:0001823 IEP     cartilage development GO:0051216 IEA     mesenchymal cell differentiation GO:0048762 IDA     neuron projection morphogenesis GO:0048812 IDA     negative regulation of cell death GO:0060548 IDA     epithelial cell differentiation GO:0030855 IEA     negative regulation of glomerular mesangial cell proliferation GO:0072125 IDA     metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136 IEA     mesenchyme development GO:0060485 ISS     ossification GO:0001503 IEA     regulation of removal of superoxide radicals GO:2000121 ISS     extracellular matrix organization GO:0030198 TAS     SMAD protein signal transduction GO:0060395 IDA     branching morphogenesis of an epithelial tube GO:0048754 IEA     skeletal system development GO:0001501 TAS     protein localization to nucleus GO:0034504 IDA     embryonic camera-type eye morphogenesis GO:0048596 IEA     negative regulation of mitotic nuclear division GO:0045839 IDA Subcellular Localization     extracellular region GO:0005576 TAS     membrane-bounded vesicle GO:0031988 IEA     extracellular space GO:0005615 IDA     extracellular matrix GO:0031012 IEA