Gene description for GDF11
Gene name growth differentiation factor 11
Gene symbol GDF11
Other names/aliases BMP-11
BMP11
Species Homo sapiens
 Database cross references - GDF11
ExoCarta ExoCarta_10220
Entrez Gene 10220
HGNC 4216
MIM 603936
UniProt O95390  
 GDF11 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GDF11
Molecular Function
    transforming growth factor beta receptor binding GO:0005160 IBA
    growth factor activity GO:0008083 IEA
    cytokine activity GO:0005125 IBA
Biological Process
    metanephros development GO:0001656 IEA
    regulation of apoptotic process GO:0042981 IBA
    spinal cord anterior/posterior patterning GO:0021512 IEA
    cell maturation GO:0048469 IEA
    palate development GO:0060021 IEA
    mesoderm development GO:0007498 TAS
    ureteric bud development GO:0001657 IEA
    growth GO:0040007 IEA
    skeletal system development GO:0001501 TAS
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA
    negative regulation of cell differentiation GO:0045596 IEA
    cell development GO:0048468 IBA
    nervous system development GO:0007399 TAS
    SMAD protein signal transduction GO:0060395 IBA
    pancreas development GO:0031016 IEA
    regulation of MAPK cascade GO:0043408 IBA
    camera-type eye morphogenesis GO:0048593 IEA
    negative regulation of cell proliferation GO:0008285 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    protein complex GO:0043234 IDA
    cellular_component GO:0005575 ND
 Experiment description of studies that identified GDF11 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GDF11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACVR2B  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which GDF11 is involved
No pathways found





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