Gene description for MKRN2
Gene name makorin ring finger protein 2
Gene symbol MKRN2
Other names/aliases HSPC070
RNF62
Species Homo sapiens
 Database cross references - MKRN2
ExoCarta ExoCarta_23609
Vesiclepedia VP_23609
Entrez Gene 23609
HGNC 7113
MIM 608426
UniProt Q9H000  
 MKRN2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MKRN2
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 ISS
Biological Process
    protein polyubiquitination GO:0000209 IEA
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 ISS
    DNA-templated transcription GO:0006351 ISS
    ubiquitin-dependent protein catabolic process GO:0006511 ISS
    spermatogenesis GO:0007283 IEA
    protein ubiquitination GO:0016567 IBA
    cell differentiation GO:0030154 IEA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified MKRN2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MKRN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUPL2 11097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 RIMS2  
Affinity Capture-RNA Homo sapiens
3 VPS35 55737
Affinity Capture-RNA Homo sapiens
4 HNRNPC 3183
Affinity Capture-MS Homo sapiens
5 MIB1 57534
Affinity Capture-RNA Homo sapiens
6 HDAC4  
Affinity Capture-RNA Homo sapiens
7 DPYSL2 1808
Affinity Capture-RNA Homo sapiens
8 NOTCH3 4854
Affinity Capture-RNA Homo sapiens
9 GART 2618
Affinity Capture-RNA Homo sapiens
10 CASP3 836
Affinity Capture-RNA Homo sapiens
11 NFIB  
Affinity Capture-RNA Homo sapiens
12 BCLAF1 9774
Affinity Capture-MS Homo sapiens
13 TRNP1  
Affinity Capture-RNA Homo sapiens
14 MTOR 2475
Affinity Capture-RNA Homo sapiens
15 TOP2B 7155
Affinity Capture-RNA Homo sapiens
16 CTBP2 1488
Affinity Capture-RNA Homo sapiens
17 FMR1 2332
Affinity Capture-MS Homo sapiens
Affinity Capture-RNA Homo sapiens
18 PARD3 56288
Affinity Capture-RNA Homo sapiens
19 E2F1 1869
Affinity Capture-RNA Homo sapiens
20 ZC3H14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 UBA1 7317
Affinity Capture-MS Homo sapiens
22 PAX2  
Affinity Capture-RNA Homo sapiens
23 DAB1 1600
Affinity Capture-RNA Homo sapiens
24 ODF2 4957
Affinity Capture-RNA Homo sapiens
25 IGF2BP1 10642
Affinity Capture-RNA Homo sapiens
26 SEMA6D  
Affinity Capture-RNA Homo sapiens
27 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
28 SLIT2 9353
Affinity Capture-RNA Homo sapiens
29 BMPR1A 657
Affinity Capture-RNA Homo sapiens
30 SIX1  
Affinity Capture-RNA Homo sapiens
31 TAF1  
Affinity Capture-RNA Homo sapiens
32 SEMA3A  
Affinity Capture-RNA Homo sapiens
33 RTN4 57142
Affinity Capture-RNA Homo sapiens
34 VASP 7408
Affinity Capture-RNA Homo sapiens
35 APP 351
Affinity Capture-RNA Homo sapiens
36 WDR36 134430
Affinity Capture-RNA Homo sapiens
37 SEMA4D  
Affinity Capture-RNA Homo sapiens
38 FGFR3 2261
Affinity Capture-RNA Homo sapiens
39 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
40 EPHA8  
Affinity Capture-RNA Homo sapiens
41 DLL1  
Affinity Capture-RNA Homo sapiens
42 TOP2A 7153
Affinity Capture-MS Homo sapiens
43 RPS20 6224
Proximity Label-MS Homo sapiens
44 IGF2BP3 10643
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
45 SNRNP70 6625
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 NEURL1  
Affinity Capture-RNA Homo sapiens
47 ID4  
Affinity Capture-RNA Homo sapiens
48 SEMA6A  
Affinity Capture-RNA Homo sapiens
49 APAF1 317
Co-fractionation Homo sapiens
50 CEMIP 57214
Affinity Capture-MS Homo sapiens
51 UBE2K 3093
Two-hybrid Homo sapiens
52 DLX2  
Affinity Capture-RNA Homo sapiens
53 SIRT6  
Affinity Capture-RNA Homo sapiens
54 TM9SF4 9777
Affinity Capture-MS Homo sapiens
55 UBE2L3 7332
Reconstituted Complex Homo sapiens
56 NEDD4L 23327
Affinity Capture-RNA Homo sapiens
57 HIBCH 26275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 KHDRBS1 10657
Affinity Capture-MS Homo sapiens
59 UNC5C  
Affinity Capture-RNA Homo sapiens
60 THRAP3 9967
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 SRSF3 6428
Affinity Capture-MS Homo sapiens
62 BMPR1B 658
Affinity Capture-RNA Homo sapiens
63 TULP3 7289
Affinity Capture-RNA Homo sapiens
64 ATRX 546
Affinity Capture-RNA Homo sapiens
65 CDT1  
Affinity Capture-RNA Homo sapiens
66 ATP6V0D1 9114
Affinity Capture-RNA Homo sapiens
67 UBB 7314
Affinity Capture-RNA Homo sapiens
68 FZD3  
Affinity Capture-RNA Homo sapiens
69 MYCN  
Affinity Capture-MS Homo sapiens
70 FOXP2 93986
Affinity Capture-RNA Homo sapiens
71 SEMA4F  
Affinity Capture-RNA Homo sapiens
72 ERBB2 2064
Affinity Capture-RNA Homo sapiens
73 FGFR1 2260
Affinity Capture-RNA Homo sapiens
74 KIF3A 11127
Affinity Capture-RNA Homo sapiens
75 PABPC4 8761
Affinity Capture-MS Homo sapiens
76 WNT11 7481
Affinity Capture-RNA Homo sapiens
77 PROX1  
Affinity Capture-RNA Homo sapiens
78 LARP4B 23185
Affinity Capture-MS Homo sapiens
79 NOTCH2 4853
Affinity Capture-RNA Homo sapiens
80 FAS 355
Proximity Label-MS Homo sapiens
81 ATXN2 6311
Affinity Capture-MS Homo sapiens
82 BRIX1 55299
Affinity Capture-MS Homo sapiens
83 CCND1 595
Affinity Capture-RNA Homo sapiens
84 BSG 682
Affinity Capture-RNA Homo sapiens
85 LRP8 7804
Affinity Capture-RNA Homo sapiens
86 RHOA 387
Affinity Capture-RNA Homo sapiens
87 SEMA6C  
Affinity Capture-RNA Homo sapiens
88 ZIC2  
Affinity Capture-RNA Homo sapiens
89 FOXC1  
Affinity Capture-RNA Homo sapiens
90 PKM 5315
Affinity Capture-RNA Homo sapiens
91 RAB8A 4218
Affinity Capture-RNA Homo sapiens
92 ITGA6 3655
Affinity Capture-RNA Homo sapiens
93 RB1CC1 9821
Affinity Capture-MS Homo sapiens
94 PARK2  
Affinity Capture-MS Homo sapiens
95 UBE2D4  
Two-hybrid Homo sapiens
96 MAP1B 4131
Affinity Capture-RNA Homo sapiens
97 STIL  
Affinity Capture-RNA Homo sapiens
98 WNT3  
Affinity Capture-RNA Homo sapiens
99 ERCC6  
Affinity Capture-RNA Homo sapiens
100 RBM4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PLD1 5337
Affinity Capture-RNA Homo sapiens
102 ATP2B1 490
Affinity Capture-RNA Homo sapiens
103 SRRT 51593
Affinity Capture-RNA Homo sapiens
104 SDK1 221935
Affinity Capture-RNA Homo sapiens
105 BVES  
Affinity Capture-RNA Homo sapiens
106 DTNBP1  
Affinity Capture-RNA Homo sapiens
107 TBC1D32 221322
Proximity Label-MS Homo sapiens
108 CCNB1 891
Affinity Capture-RNA Homo sapiens
109 PABPC1 26986
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
110 CARM1 10498
Affinity Capture-RNA Homo sapiens
111 FYN 2534
Affinity Capture-RNA Homo sapiens
112 C9orf41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 MYH9 4627
Affinity Capture-MS Homo sapiens
114 GDF11 10220
Affinity Capture-RNA Homo sapiens
115 RBMS2 5939
Affinity Capture-MS Homo sapiens
116 PDE4D  
Affinity Capture-RNA Homo sapiens
117 CDH4 1002
Affinity Capture-RNA Homo sapiens
118 GLI3 2737
Affinity Capture-RNA Homo sapiens
119 CNTN1 1272
Affinity Capture-RNA Homo sapiens
120 WNT5A 7474
Affinity Capture-RNA Homo sapiens
121 PLAG1  
Affinity Capture-RNA Homo sapiens
122 LUC7L2 51631
Affinity Capture-MS Homo sapiens
123 NCS1 23413
Affinity Capture-RNA Homo sapiens
124 ALYREF 10189
Affinity Capture-MS Homo sapiens
125 MYH10 4628
Affinity Capture-MS Homo sapiens
126 PABPN1 8106
Affinity Capture-MS Homo sapiens
127 SDCCAG8  
Affinity Capture-RNA Homo sapiens
128 MNAT1  
Affinity Capture-RNA Homo sapiens
129 IARS 3376
Affinity Capture-MS Homo sapiens
130 PTPRA 5786
Affinity Capture-RNA Homo sapiens
131 NUMB 8650
Affinity Capture-RNA Homo sapiens
132 DBN1 1627
Affinity Capture-RNA Homo sapiens
133 GLTSCR2  
Affinity Capture-MS Homo sapiens
134 HIF1A 3091
Affinity Capture-RNA Homo sapiens
135 GLI2  
Affinity Capture-RNA Homo sapiens
136 EML1 2009
Affinity Capture-RNA Homo sapiens
137 LARP1 23367
Affinity Capture-MS Homo sapiens
138 ELAVL2 1993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 P2RX4 5025
Affinity Capture-RNA Homo sapiens
140 HNRNPDL 9987
Affinity Capture-MS Homo sapiens
141 PAIP2B  
Affinity Capture-MS Homo sapiens
142 FOXO6  
Affinity Capture-RNA Homo sapiens
143 ACAT1 38
Affinity Capture-RNA Homo sapiens
144 TMEM30A 55754
Affinity Capture-RNA Homo sapiens
145 BAX 581
Affinity Capture-RNA Homo sapiens
146 C11orf57  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 XPO1 7514
Affinity Capture-MS Homo sapiens
148 CASZ1  
Affinity Capture-RNA Homo sapiens
149 GLE1 2733
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
150 ROBO1 6091
Affinity Capture-RNA Homo sapiens
151 SARM1 23098
Affinity Capture-RNA Homo sapiens
152 PLRG1 5356
Affinity Capture-MS Homo sapiens
153 CTNNB1 1499
Affinity Capture-RNA Homo sapiens
154 PARP12 64761
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 DLG1 1739
Affinity Capture-RNA Homo sapiens
156 SUN1 23353
Affinity Capture-RNA Homo sapiens
157 LIMK1 3984
Affinity Capture-RNA Homo sapiens
158 SEMA3D  
Affinity Capture-RNA Homo sapiens
159 TRIO 7204
Affinity Capture-RNA Homo sapiens
160 CUL3 8452
Affinity Capture-MS Homo sapiens
161 MYO7A 4647
Affinity Capture-RNA Homo sapiens
162 FZD1 8321
Affinity Capture-RNA Homo sapiens
163 MAGI2  
Affinity Capture-RNA Homo sapiens
164 CLN5  
Affinity Capture-RNA Homo sapiens
165 ARF6 382
Affinity Capture-RNA Homo sapiens
166 SYNE2 23224
Affinity Capture-RNA Homo sapiens
167 EPRS 2058
Affinity Capture-MS Homo sapiens
168 CEP290  
Affinity Capture-RNA Homo sapiens
169 ZC3H11A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 LARS 51520
Affinity Capture-MS Homo sapiens
171 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
172 DSCAML1  
Affinity Capture-RNA Homo sapiens
173 NXF1 10482
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 CDC42 998
Affinity Capture-RNA Homo sapiens
175 EPHA7 2045
Affinity Capture-RNA Homo sapiens
176 PITPNA 5306
Affinity Capture-RNA Homo sapiens
177 HES4  
Affinity Capture-RNA Homo sapiens
178 PRR3  
Affinity Capture-MS Homo sapiens
179 EXT1 2131
Affinity Capture-RNA Homo sapiens
180 PRPF19 27339
Affinity Capture-MS Homo sapiens
181 MYC  
Affinity Capture-RNA Homo sapiens
182 ZC3H18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
183 EGFR 1956
Affinity Capture-RNA Homo sapiens
184 PABPC5 140886
Affinity Capture-MS Homo sapiens
185 EHMT2 10919
Affinity Capture-RNA Homo sapiens
186 TRA2A 29896
Affinity Capture-MS Homo sapiens
187 PABPN1L  
Affinity Capture-MS Homo sapiens
188 OPA1 4976
Affinity Capture-RNA Homo sapiens
189 NRCAM  
Affinity Capture-RNA Homo sapiens
190 RHOB 388
Affinity Capture-RNA Homo sapiens
191 FYTTD1  
Affinity Capture-MS Homo sapiens
192 EN2  
Affinity Capture-RNA Homo sapiens
193 S1PR1 1901
Affinity Capture-RNA Homo sapiens
194 CYFIP2 26999
Affinity Capture-RNA Homo sapiens
195 ASAP1 50807
Affinity Capture-RNA Homo sapiens
196 EPHB3 2049
Affinity Capture-RNA Homo sapiens
197 ARL13B 200894
Affinity Capture-RNA Homo sapiens
198 CYFIP1 23191
Affinity Capture-RNA Homo sapiens
199 RAE1 8480
Affinity Capture-MS Homo sapiens
200 SLIT1 6585
Affinity Capture-RNA Homo sapiens
201 CHD7  
Affinity Capture-RNA Homo sapiens
202 UBE2D1 7321
Two-hybrid Homo sapiens
203 PAIP1 10605
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
204 TBX3 6926
Affinity Capture-RNA Homo sapiens
205 PPT1 5538
Affinity Capture-RNA Homo sapiens
206 LAMB1 3912
Affinity Capture-RNA Homo sapiens
207 ADCY1 107
Affinity Capture-RNA Homo sapiens
208 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
209 MKRN1 23608
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 CCND2  
Affinity Capture-RNA Homo sapiens
211 PARP1 142
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
212 CASP2  
Affinity Capture-RNA Homo sapiens
213 PANK2 80025
Affinity Capture-RNA Homo sapiens
214 ZFC3H1 196441
Affinity Capture-MS Homo sapiens
215 AHI1  
Affinity Capture-RNA Homo sapiens
216 IFT20 90410
Affinity Capture-RNA Homo sapiens
217 TP53 7157
Affinity Capture-RNA Homo sapiens
218 SATB2  
Affinity Capture-RNA Homo sapiens
219 TGIF2  
Affinity Capture-RNA Homo sapiens
220 MACF1 23499
Affinity Capture-RNA Homo sapiens
221 RBPJ 3516
Affinity Capture-RNA Homo sapiens
222 SYNJ1 8867
Affinity Capture-RNA Homo sapiens
223 WNT10B 7480
Affinity Capture-RNA Homo sapiens
224 APOBEC3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
225 LONP1 9361
Co-fractionation Homo sapiens
226 HDAC6 10013
Affinity Capture-RNA Homo sapiens
227 EPHA4 2043
Affinity Capture-RNA Homo sapiens
228 IRS2 8660
Affinity Capture-RNA Homo sapiens
229 TYRO3 7301
Affinity Capture-RNA Homo sapiens
230 CASK 8573
Affinity Capture-RNA Homo sapiens
231 MKRN3  
Affinity Capture-MS Homo sapiens
232 PTBP3 9991
Affinity Capture-MS Homo sapiens
233 HDAC1 3065
Affinity Capture-RNA Homo sapiens
234 POU4F1  
Affinity Capture-RNA Homo sapiens
235 CREB1  
Affinity Capture-RNA Homo sapiens
236 EZH1  
Affinity Capture-RNA Homo sapiens
237 ATF1  
Affinity Capture-RNA Homo sapiens
238 NIFK 84365
Affinity Capture-MS Homo sapiens
239 CDK1 983
Affinity Capture-RNA Homo sapiens
240 NTNG2  
Affinity Capture-RNA Homo sapiens
241 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
242 UFL1 23376
Affinity Capture-MS Homo sapiens
243 RB1 5925
Affinity Capture-RNA Homo sapiens
244 EPHA3 2042
Affinity Capture-RNA Homo sapiens
245 RHEB 6009
Affinity Capture-RNA Homo sapiens
246 RBM4 5936
Affinity Capture-MS Homo sapiens
247 SEMA4B  
Affinity Capture-RNA Homo sapiens
248 DDX3X 1654
Affinity Capture-RNA Homo sapiens
249 EZH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-RNA Homo sapiens
250 ATP6AP1 537
Affinity Capture-RNA Homo sapiens
251 CELSR2  
Affinity Capture-RNA Homo sapiens
252 PRKCA 5578
Affinity Capture-RNA Homo sapiens
253 C1orf109  
Two-hybrid Homo sapiens
254 ARF1 375
Affinity Capture-RNA Homo sapiens
255 SERBP1 26135
Proximity Label-MS Homo sapiens
256 MYO6 4646
Affinity Capture-MS Homo sapiens
257 TENM3 55714
Affinity Capture-RNA Homo sapiens
258 GNB2L1 10399
Two-hybrid Homo sapiens
259 ISL2  
Affinity Capture-RNA