Gene description for ADCY1
Gene name adenylate cyclase 1 (brain)
Gene symbol ADCY1
Other names/aliases AC1
DFNB44
Species Homo sapiens
 Database cross references - ADCY1
ExoCarta ExoCarta_107
Entrez Gene 107
HGNC 232
MIM 103072
UniProt Q08828  
 ADCY1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ADCY1
Molecular Function
    ATP binding GO:0005524 IEA
    calmodulin binding GO:0005516 IEA
    calcium- and calmodulin-responsive adenylate cyclase activity GO:0008294 NAS
    metal ion binding GO:0046872 IEA
Biological Process
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    axonogenesis GO:0007409 IEA
    activation of protein kinase A activity GO:0034199 TAS
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 TAS
    response to drug GO:0042493 IEA
    cAMP biosynthetic process GO:0006171 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    response to lithium ion GO:0010226 IEA
    renal water homeostasis GO:0003091 TAS
    adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 TAS
    innate immune response GO:0045087 TAS
    regulation of circadian rhythm GO:0042752 ISS
    long-term memory GO:0007616 IEA
    energy reserve metabolic process GO:0006112 TAS
    cellular response to glucagon stimulus GO:0071377 TAS
    circadian rhythm GO:0007623 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    synaptic transmission GO:0007268 TAS
    intracellular signal transduction GO:0035556 IEA
    activation of phospholipase C activity GO:0007202 TAS
    signal transduction GO:0007165 TAS
    small molecule metabolic process GO:0044281 TAS
    water transport GO:0006833 TAS
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 IEA
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified ADCY1 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ADCY1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADCY2 108
Invitro Homo sapiens
View the network image/svg+xml



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