Gene description for BAX
Gene name	BCL2-associated X protein
Gene symbol	BAX
Other names/aliases	BCL2L4
Species	Homo sapiens
Database cross references - BAX
ExoCarta	ExoCarta_581
Entrez Gene	581
HGNC	959
MIM	600040
UniProt	Q07812
BAX identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337

Gene ontology annotations for BAX

Molecular Function     protein binding GO:0005515 IPI     lipid binding GO:0008289 IDA     protein homodimerization activity GO:0042803 IPI     BH3 domain binding GO:0051434 IPI     protein heterodimerization activity GO:0046982 IPI     identical protein binding GO:0042802 IPI     channel activity GO:0015267 IDA Biological Process     regulation of protein heterodimerization activity GO:0043497 IPI     homeostasis of number of cells within a tissue GO:0048873 IEA     regulation of protein homodimerization activity GO:0043496 IDA     intrinsic apoptotic signaling pathway GO:0097193 TAS     viral process GO:0016032 IEA     negative regulation of neuron apoptotic process GO:0043524 IEA     negative regulation of apoptotic signaling pathway GO:2001234 IEA     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IBA     Sertoli cell proliferation GO:0060011 IEA     regulation of cell cycle GO:0051726 IEA     protein oligomerization GO:0051259 IDA     development of secondary sexual characteristics GO:0045136 IEA     cerebral cortex development GO:0021987 IEA     thymocyte apoptotic process GO:0070242 IEA     positive regulation of apoptotic process involved in mammary gland involution GO:0060058 IEA     positive regulation of developmental pigmentation GO:0048087 IEA     positive regulation of neuron apoptotic process GO:0043525 IDA     retina development in camera-type eye GO:0060041 IEA     response to axon injury GO:0048678 IEA     T cell homeostatic proliferation GO:0001777 IEA     response to salt stress GO:0009651 IEA     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA     release of matrix enzymes from mitochondria GO:0032976 IDA     negative regulation of peptidyl-serine phosphorylation GO:0033137 IEA     positive regulation of IRE1-mediated unfolded protein response GO:1903896 TAS     regulation of mitochondrial membrane potential GO:0051881 IDA     B cell homeostasis GO:0001782 IEA     apoptotic mitochondrial changes GO:0008637 IDA     apoptotic process involved in embryonic digit morphogenesis GO:1902263 IEA     negative regulation of protein binding GO:0032091 IDA     B cell receptor apoptotic signaling pathway GO:1990117 IDA     mitochondrial fragmentation involved in apoptotic process GO:0043653 IDA     fertilization GO:0009566 IEA     endoplasmic reticulum calcium ion homeostasis GO:0032469 TAS     positive regulation of apoptotic process GO:0043065 IMP     establishment or maintenance of transmembrane electrochemical gradient GO:0010248 IDA     kidney development GO:0001822 IEA     myeloid cell homeostasis GO:0002262 IEA     response to gamma radiation GO:0010332 IEA     B cell negative selection GO:0002352 IEA     B cell homeostatic proliferation GO:0002358 IEA     apoptotic process involved in patterning of blood vessels GO:1902262 IEA     ovarian follicle development GO:0001541 IEA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IBA     activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 IDA     release of cytochrome c from mitochondria GO:0001836 IDA     positive regulation of protein oligomerization GO:0032461 IDA     positive regulation of release of cytochrome c from mitochondria GO:0090200 IDA     neuron apoptotic process GO:0051402 IEA     intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IEA     odontogenesis of dentin-containing tooth GO:0042475 IEA     protein homooligomerization GO:0051260 IDA     retinal cell programmed cell death GO:0046666 IEA     spermatid differentiation GO:0048515 IEA     extrinsic apoptotic signaling pathway GO:0097191 IDA     positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 IMP     retinal cell apoptotic process GO:1990009 IMP     positive regulation of apoptotic DNA fragmentation GO:1902512 IMP     vagina development GO:0060068 IEA     apoptotic signaling pathway GO:0097190 IDA     blood vessel remodeling GO:0001974 IEA     regulation of mitochondrial membrane permeability involved in programmed necrotic cell death GO:1902445 IEA     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IC     mitochondrion morphogenesis GO:0070584 IEA     transformed cell apoptotic process GO:0006927 IMP     hypothalamus development GO:0021854 IEA     programmed cell death GO:0012501 TAS     neuron migration GO:0001764 IEA     response to toxic substance GO:0009636 IDA     regulation of mammary gland epithelial cell proliferation GO:0033599 IEA     negative regulation of fibroblast proliferation GO:0048147 IEA     ectopic germ cell programmed cell death GO:0035234 IEA     post-embryonic camera-type eye morphogenesis GO:0048597 IEA     positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 TAS     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IMP     apoptotic process GO:0006915 TAS     mitochondrial fusion GO:0008053 IDA     regulation of nitrogen utilization GO:0006808 IEA     positive regulation of B cell apoptotic process GO:0002904 IEA     protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 IEA     intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 TAS     glycosphingolipid metabolic process GO:0006687 IEA     cellular response to UV GO:0034644 IEA     B cell apoptotic process GO:0001783 IDA     activation of signaling protein activity involved in unfolded protein response GO:0006987 TAS     negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 IEA     germ cell development GO:0007281 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IMP     positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IEA Subcellular Localization     nuclear envelope GO:0005635 IDA     mitochondrial permeability transition pore complex GO:0005757 IDA     membrane GO:0016020 IDA     Bcl-2 family protein complex GO:0097136 IDA     mitochondrial outer membrane GO:0005741 TAS     endoplasmic reticulum membrane GO:0005789 IDA     endoplasmic reticulum GO:0005783 IDA     mitochondrion GO:0005739 IDA     BAX complex GO:0097144 IDA     extracellular exosome GO:0070062 IDA     nucleus GO:0005634 IMP     cytosol GO:0005829 TAS     pore complex GO:0046930 IDA