Gene description for FCGRT
Gene name Fc fragment of IgG, receptor, transporter, alpha
Gene symbol FCGRT
Other names/aliases FCRN
alpha-chain
Species Homo sapiens
 Database cross references - FCGRT
ExoCarta ExoCarta_2217
Vesiclepedia VP_2217
Entrez Gene 2217
HGNC 3621
MIM 601437
UniProt P55899  
 FCGRT identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FCGRT
Molecular Function
    protein binding GO:0005515 IPI
    IgG binding GO:0019864 IDA
    beta-2-microglobulin binding GO:0030881 IBA
    peptide antigen binding GO:0042605 ISS
Biological Process
    IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor GO:0002416 NAS
    immune response GO:0006955 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    external side of plasma membrane GO:0009897 IBA
    endosome membrane GO:0010008 IEA
 Experiment description of studies that identified FCGRT in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FCGRT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CITED1 4435
Affinity Capture-MS Homo sapiens
2 SRP19 6728
Affinity Capture-MS Homo sapiens
3 HFE  
Affinity Capture-MS Homo sapiens
4 SGCE 8910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SNX3 8724
Affinity Capture-MS Homo sapiens
6 HLA-E 3133
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PCDHGA11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ALB 213
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
9 PBK  
Affinity Capture-MS Homo sapiens
10 STK36  
Affinity Capture-MS Homo sapiens
11 DIEXF  
Affinity Capture-MS Homo sapiens
12 C1orf112  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SBDS 51119
Affinity Capture-MS Homo sapiens
14 FRAT2  
Affinity Capture-MS Homo sapiens
15 CCDC43 124808
Affinity Capture-MS Homo sapiens
16 SURF2  
Affinity Capture-MS Homo sapiens
17 LRP6 4040
Affinity Capture-MS Homo sapiens
18 CDC123 8872
Affinity Capture-MS Homo sapiens
19 LRP5 4041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 HLA-B 3106
Affinity Capture-MS Homo sapiens
21 FGFR4 2264
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMEM129  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 C3orf52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ELP4  
Affinity Capture-MS Homo sapiens
25 ATG16L1 55054
Affinity Capture-MS Homo sapiens
26 KLRC1  
Affinity Capture-MS Homo sapiens
27 METTL18  
Affinity Capture-MS Homo sapiens
28 EXOC7 23265
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 FGFR1 2260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PTPRF 5792
Affinity Capture-MS Homo sapiens
31 KIF14 9928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 DSC3 1825
Affinity Capture-MS Homo sapiens
33 GOLIM4 27333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SEZ6L2 26470
Affinity Capture-MS Homo sapiens
35 WBP4  
Affinity Capture-MS Homo sapiens
36 CHMP1A 5119
Affinity Capture-MS Homo sapiens
37 ATP1B4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TXNL4B  
Affinity Capture-MS Homo sapiens
39 NAA50 80218
Affinity Capture-MS Homo sapiens
40 GAL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ANTXR1 84168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CLU 1191
Affinity Capture-MS Homo sapiens
43 LARP7 51574
Affinity Capture-MS Homo sapiens
44 BTF3L4 91408
Affinity Capture-MS Homo sapiens
45 RAB4A 5867
Proximity Label-MS Homo sapiens
46 APLP2 334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TNPO2 30000
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SERPINC1 462
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CD1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CBX5 23468
Affinity Capture-MS Homo sapiens
51 CNTN1 1272
Affinity Capture-MS Homo sapiens
52 THBS1 7057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 EXOC6B 23233
Affinity Capture-MS Homo sapiens
54 HGFAC 3083
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CLDN19  
Two-hybrid Homo sapiens
56 TIMELESS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ITM2B 9445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 MESDC2 23184
Affinity Capture-MS Homo sapiens
59 UPK2 7379
Two-hybrid Homo sapiens
60 ULBP3 79465
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 NINJ2  
Two-hybrid Homo sapiens
62 BAX 581
Co-fractionation Homo sapiens
63 FURIN 5045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 LRP4 4038
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 PCDH1 5097
Affinity Capture-MS Homo sapiens
66 B4GALT5 9334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 IQCB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 RTN4R 65078
Affinity Capture-MS Homo sapiens
69 TNPO3 23534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 A4GALT  
Affinity Capture-MS Homo sapiens
71 SLC39A1 27173
Affinity Capture-MS Homo sapiens
72 XPO6 23214
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 PCDH7 5099
Affinity Capture-MS Homo sapiens
74 HES4  
Affinity Capture-MS Homo sapiens
75 FGFR2 2263
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 KIF1BP 26128
Affinity Capture-MS Homo sapiens
77 PCDH10 57575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 EGFR 1956
Negative Genetic Homo sapiens
79 MPZL1 9019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 PMP22  
Two-hybrid Homo sapiens
81 DUSP9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 PDSS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 GFRA3 2676
Affinity Capture-MS Homo sapiens
84 RAB11A 8766
Proximity Label-MS Homo sapiens
85 CMSS1  
Affinity Capture-MS Homo sapiens
86 NUP133 55746
Affinity Capture-MS Homo sapiens
87 SCGB1D1  
Affinity Capture-MS Homo sapiens
88 RWDD4 201965
Affinity Capture-MS Homo sapiens
89 ULBP2 80328
Affinity Capture-MS Homo sapiens
90 ABCD4 5826
Affinity Capture-MS Homo sapiens
91 CD1B 910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 HBA2 3040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 TMEM30B 161291
Affinity Capture-MS Homo sapiens
94 TNFSF9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 PODXL2 50512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 TUT1  
Affinity Capture-MS Homo sapiens
97 GORASP1 64689
Affinity Capture-MS Homo sapiens
98 COG6 57511
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 KLF5  
Affinity Capture-MS Homo sapiens
100 PRTG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 NCAPD2 9918
Affinity Capture-MS Homo sapiens
102 PTPRS 5802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 SH3GLB1 51100
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 B2M 567
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 GTF2E1 2960
Affinity Capture-MS Homo sapiens
106 LDLR 3949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 QRSL1  
Affinity Capture-MS Homo sapiens
108 UBLCP1  
Affinity Capture-MS Homo sapiens
109 DERL1 79139
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 PCDH17  
Affinity Capture-MS Homo sapiens
111 DYNC2H1 79659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 FAM3C 10447
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FCGRT is involved
No pathways found





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