Gene description for ANTXR1
Gene name anthrax toxin receptor 1
Gene symbol ANTXR1
Other names/aliases ATR
GAPO
TEM8
Species Homo sapiens
 Database cross references - ANTXR1
ExoCarta ExoCarta_84168
Vesiclepedia VP_84168
Entrez Gene 84168
HGNC 21014
MIM 606410
UniProt Q9H6X2  
 ANTXR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Endothelial cells 26027894    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 25844599    
 Gene ontology annotations for ANTXR1
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IBA
    transmembrane signaling receptor activity GO:0004888 IDA
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 IDA
    metal ion binding GO:0046872 IEA
    actin filament binding GO:0051015 IDA
Biological Process
    blood vessel development GO:0001568 IEA
    actin cytoskeleton organization GO:0030036 IDA
    substrate adhesion-dependent cell spreading GO:0034446 IDA
    negative regulation of extracellular matrix assembly GO:1901202 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 HDA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    endosome membrane GO:0010008 TAS
    lamellipodium membrane GO:0031258 IDA
    filopodium membrane GO:0031527 IDA
 Experiment description of studies that identified ANTXR1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
8
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for ANTXR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K7 5609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ATPIF1 93974
Affinity Capture-MS Homo sapiens
3 KLK15  
Affinity Capture-MS Homo sapiens
4 CNTNAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 OCLN 100506658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TRIM51  
Two-hybrid Homo sapiens
7 TRIM35 23087
Two-hybrid Homo sapiens
8 RSAD1  
Affinity Capture-MS Homo sapiens
9 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 UBC 7316
Reconstituted Complex Homo sapiens
11 SAMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PTPN1 5770
Affinity Capture-MS Homo sapiens
13 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 POTEF 728378
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ERF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LMO1  
Affinity Capture-MS Homo sapiens
17 PC 5091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 KLF8  
Affinity Capture-MS Homo sapiens
19 HLA-B 3106
Affinity Capture-MS Homo sapiens
20 TRMT44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CLEC2B  
Affinity Capture-MS Homo sapiens
22 UTS2 10911
Affinity Capture-MS Homo sapiens
23 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 PMEL 6490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 B4GALNT4  
Affinity Capture-MS Homo sapiens
26 LMAN2 10960
Affinity Capture-MS Homo sapiens
27 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PCYOX1 51449
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 KIF14 9928
Affinity Capture-MS Homo sapiens
30 ITLN1 55600
Affinity Capture-MS Homo sapiens
31 PAM16  
Affinity Capture-MS Homo sapiens
32 CA11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 COX7A2 1347
Affinity Capture-MS Homo sapiens
34 MIB1 57534
Proximity Label-MS Homo sapiens
35 ANTXR1 84168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SPSB2  
Affinity Capture-MS Homo sapiens
37 TUBA1A 7846
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 BAG6 7917
Affinity Capture-MS Homo sapiens
39 VSIG4  
Affinity Capture-MS Homo sapiens
40 PANK4 55229
Affinity Capture-MS Homo sapiens
41 CSPG4 1464
Affinity Capture-MS Homo sapiens
42 Sidt2  
Affinity Capture-MS Mus musculus
43 MYH9 4627
Affinity Capture-MS Homo sapiens
44 GDF11 10220
Affinity Capture-MS Homo sapiens
45 WNT5A 7474
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 EEF2 1938
Affinity Capture-MS Homo sapiens
47 LYPD1  
Affinity Capture-MS Homo sapiens
48 TPM3 7170
Affinity Capture-MS Homo sapiens
49 RAB10 10890
Affinity Capture-MS Homo sapiens
50 DNAJC12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ACSL4 2182
Affinity Capture-MS Homo sapiens
52 SEC61B 10952
Proximity Label-MS Homo sapiens
53 BZW1 9689
Affinity Capture-MS Homo sapiens
54 LY86  
Affinity Capture-MS Homo sapiens
55 UPK2 7379
Affinity Capture-MS Homo sapiens
56 FOXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 RAB18 22931
Affinity Capture-MS Homo sapiens
58 GJB2  
Affinity Capture-MS Homo sapiens
59 TMEM30A 55754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 FLNA 2316
Affinity Capture-MS Homo sapiens
61 TNFSF8  
Affinity Capture-MS Homo sapiens
62 RLIM 51132
Affinity Capture-MS Homo sapiens
63 CDC42EP1 11135
Affinity Capture-MS Homo sapiens
64 CNP 1267
Affinity Capture-MS Homo sapiens
65 RICTOR 253260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 MYO19  
Affinity Capture-MS Homo sapiens
67 ARF6 382
Proximity Label-MS Homo sapiens
68 H6PD 9563
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 Bsdc1  
Affinity Capture-MS Mus musculus
70 SPACA1 81833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 KIRREL 55243
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 GNAS 2778
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
74 TJP2 9414
Affinity Capture-MS Homo sapiens
75 MYC  
Affinity Capture-MS Homo sapiens
76 ASB10  
Two-hybrid Homo sapiens
77 PRMT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 SLC10A1  
Affinity Capture-MS Homo sapiens
79 GALNT7 51809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 ETV3  
Affinity Capture-MS Homo sapiens
81 COX2 4513
Affinity Capture-MS Homo sapiens
82 Mad2l1 56150
Affinity Capture-MS Mus musculus
83 Ppp1cb 19046
Affinity Capture-MS Mus musculus
84 SYN1  
Affinity Capture-MS Homo sapiens
85 LYZL2  
Affinity Capture-MS Homo sapiens
86 DMXL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 CRLF2 64109
Affinity Capture-MS Homo sapiens
88 MANEA 79694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 NAAA  
Affinity Capture-MS Homo sapiens
90 DTX3L 151636
Two-hybrid Homo sapiens
91 PDIA5 10954
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 CIT 11113
Affinity Capture-MS Homo sapiens
93 RHOC 389
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
94 FCGRT 2217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 PLXNA1 5361
Affinity Capture-MS Homo sapiens
96 TUBB3 10381
Affinity Capture-MS Homo sapiens
97 PPOX 5498
Affinity Capture-MS Homo sapiens
98 S100A10 6281
Affinity Capture-MS Homo sapiens
99 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
100 RBCK1  
Two-hybrid Homo sapiens
101 SLAMF1 6504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 TUBB4A 10382
Affinity Capture-MS Homo sapiens
103 TUBB6 84617
Affinity Capture-MS Homo sapiens
104 ESYT1 23344
Affinity Capture-MS Homo sapiens
105 GZMH  
Affinity Capture-MS Homo sapiens
106 LAGE3  
Affinity Capture-MS Homo sapiens
107 DHX38 9785
Affinity Capture-MS Homo sapiens
108 RPL23 9349
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 LAMB2 3913
Affinity Capture-MS Homo sapiens
110 RNF182  
Two-hybrid Homo sapiens
111 KANK2 25959
Affinity Capture-MS Homo sapiens
112 LRP11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 WFS1 7466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 TMEM132A 54972
Affinity Capture-MS Homo sapiens
115 CAV1 857
Proximity Label-MS Homo sapiens
116 Tecpr2  
Affinity Capture-MS Mus musculus
117 ZNF146  
Affinity Capture-MS Homo sapiens
118 PCDHB3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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