Gene description for UTS2
Gene name urotensin 2
Gene symbol UTS2
Other names/aliases PRO1068
Species Homo sapiens
 Database cross references - UTS2
ExoCarta ExoCarta_10911
Entrez Gene 10911
HGNC 12636
MIM 604097
UniProt O95399  
 UTS2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for UTS2
Molecular Function
    hormone activity GO:0005179 IEA
    receptor binding GO:0005102 TAS
Biological Process
    negative regulation of urine volume GO:0035811 IEA
    negative regulation of renal sodium excretion GO:0035814 IEA
    regulation of blood pressure GO:0008217 TAS
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    positive regulation of collagen biosynthetic process GO:0032967 IEA
    positive regulation of angiogenesis GO:0045766 IEA
    positive regulation of vasodilation GO:0045909 IEA
    positive regulation of blood pressure GO:0045777 IEA
    response to testosterone GO:0033574 IEA
    positive regulation of fibroblast proliferation GO:0048146 IEA
    negative regulation of blood pressure GO:0045776 IEA
    synaptic transmission GO:0007268 TAS
    negative regulation of heart rate GO:0010459 IEA
    response to hypoxia GO:0001666 IEA
    positive regulation of circadian sleep/wake cycle, REM sleep GO:0046005 IEA
    negative regulation of insulin secretion GO:0046676 IEA
    positive regulation of circadian sleep/wake cycle, wakefulness GO:0010841 IEA
    muscle contraction GO:0006936 TAS
    positive regulation of synaptic transmission, cholinergic GO:0032224 IEA
    positive regulation of cell differentiation GO:0045597 IEA
    response to drug GO:0042493 IEA
    negative regulation of glomerular filtration GO:0003105 IEA
    positive regulation of fibroblast migration GO:0010763 IEA
    positive regulation of heart rate GO:0010460 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IEA
    cytosol GO:0005829 IEA
 Experiment description of studies that identified UTS2 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UTS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UTS2R  
Invivo Homo sapiens
2 UTS2 10911
Invivo Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which UTS2 is involved
G alpha (q) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
Peptide ligand-binding receptors TAS Reactome

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