Gene description for KANK2
Gene name KN motif and ankyrin repeat domains 2
Gene symbol KANK2
Other names/aliases ANKRD25
MXRA3
PPKWH
SIP
Species Homo sapiens
 Database cross references - KANK2
ExoCarta ExoCarta_25959
Vesiclepedia VP_25959
Entrez Gene 25959
HGNC 29300
MIM 614610
UniProt Q63ZY3  
 KANK2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for KANK2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    apoptotic process GO:0006915 IEA
    negative regulation of cell population proliferation GO:0008285 IBA
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of actin filament polymerization GO:0030837 IEA
    negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 IBA
    negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 IDA
    regulation of Rho protein signal transduction GO:0035023 IMP
    negative regulation of programmed cell death GO:0043069 IDA
    negative regulation of vitamin D receptor signaling pathway GO:0070563 IBA
    negative regulation of vitamin D receptor signaling pathway GO:0070563 IMP
    kidney epithelium development GO:0072073 IMP
    podocyte cell migration GO:0090521 IMP
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IBA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified KANK2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KANK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Two-hybrid Homo sapiens
2 MORN3  
Two-hybrid Homo sapiens
3 MCRS1  
Two-hybrid Homo sapiens
4 CCDC88B 283234
Two-hybrid Homo sapiens
5 GMNN  
Two-hybrid Homo sapiens
6 OCLN 100506658
Proximity Label-MS Homo sapiens
7 MITD1 129531
Two-hybrid Homo sapiens
8 DCP1B  
Affinity Capture-MS Homo sapiens
9 KIFC3 3801
Two-hybrid Homo sapiens
10 AES 166
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 BBS7 55212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CARD9 64170
Two-hybrid Homo sapiens
13 FAM184A 79632
Proximity Label-MS Homo sapiens
14 TEX11  
Two-hybrid Homo sapiens
15 ZNHIT1  
Two-hybrid Homo sapiens
16 GOLGA6A  
Two-hybrid Homo sapiens
17 ARL14EP  
Two-hybrid Homo sapiens
18 CSNK2A1 1457
Biochemical Activity Homo sapiens
19 IL16  
Two-hybrid Homo sapiens
20 GRB10 2887
Two-hybrid Homo sapiens
21 SRSF2 6427
Affinity Capture-MS Homo sapiens
22 THSD4 79875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 FLOT1 10211
Proximity Label-MS Homo sapiens
24 ZNF414  
Two-hybrid Homo sapiens
25 TRIM54  
Two-hybrid Homo sapiens
26 ZMAT2  
Two-hybrid Homo sapiens
27 NDC80 10403
Proximity Label-MS Homo sapiens
28 LMO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 CHCHD4  
Affinity Capture-MS Homo sapiens
30 ZNF648  
Two-hybrid Homo sapiens
31 PPFIBP1 8496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 YWHAZ 7534
Affinity Capture-MS Homo sapiens
33 CEP70  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 NECAB2  
Two-hybrid Homo sapiens
35 SCNM1  
Two-hybrid Homo sapiens
36 TRIM35 23087
Two-hybrid Homo sapiens
37 LENG1  
Two-hybrid Homo sapiens
38 CADPS  
Two-hybrid Homo sapiens
39 PCBD1 5092
Two-hybrid Homo sapiens
40 FBXW7  
Affinity Capture-MS Homo sapiens
41 GKAP1  
Two-hybrid Homo sapiens
42 KRT40  
Two-hybrid Homo sapiens
43 NCOA5  
Two-hybrid Homo sapiens
44 ZNF212  
Two-hybrid Homo sapiens
45 BRPF3  
Affinity Capture-MS Homo sapiens
46 OIP5  
Two-hybrid Homo sapiens
47 KLHL33  
Affinity Capture-MS Homo sapiens
48 OBSL1 23363
Affinity Capture-MS Homo sapiens
49 NCOA3  
Affinity Capture-Western Homo sapiens
50 MTUS2 23281
Two-hybrid Homo sapiens
51 RHOB 388
Proximity Label-MS Homo sapiens
52 DYNLL1 8655
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 P3H1 64175
Affinity Capture-MS Homo sapiens
54 MOB3C  
Two-hybrid Homo sapiens
55 LYN 4067
Proximity Label-MS Homo sapiens
56 NPAS1  
Affinity Capture-MS Homo sapiens
57 PFDN6 10471
Two-hybrid Homo sapiens
58 WASF3 10810
Two-hybrid Homo sapiens
59 KIF21A 55605
Affinity Capture-MS Homo sapiens
60 LMO4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
61 ASB15 142685
Two-hybrid Homo sapiens
62 KIF14 9928
Affinity Capture-MS Homo sapiens
63 C2orf68  
Two-hybrid Homo sapiens
64 CINP  
Two-hybrid Homo sapiens
65 NCOA1  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
66 PRR5L  
Two-hybrid Homo sapiens
67 AEN  
Two-hybrid Homo sapiens
68 LOC100131303  
Two-hybrid Homo sapiens
69 HSPB2  
Two-hybrid Homo sapiens
70 GPSM1 26086
Two-hybrid Homo sapiens
71 WASH1 100287171
Two-hybrid Homo sapiens
72 KRT34  
Two-hybrid Homo sapiens
73 TSGA10IP  
Two-hybrid Homo sapiens
74 PSMB4 5692
Two-hybrid Homo sapiens
75 CEP55 55165
Two-hybrid Homo sapiens
76 FHL3 2275
Two-hybrid Homo sapiens
77 VWC2  
Two-hybrid Homo sapiens
78 ANTXR1 84168
Affinity Capture-MS Homo sapiens
79 CHCHD3 54927
Two-hybrid Homo sapiens
80 CCDC33 80125
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
81 IKZF3  
Two-hybrid Homo sapiens
82 Sec24c  
Affinity Capture-MS Mus musculus
83 PSMD14 10213
Affinity Capture-MS Homo sapiens
84 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
85 PROZ 8858
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 CCDC57 284001
Two-hybrid Homo sapiens
87 LHX1  
Two-hybrid Homo sapiens
88 CDH1 999
Proximity Label-MS Homo sapiens
89 NTRK1 4914
Affinity Capture-MS Homo sapiens
90 FOXK2  
Affinity Capture-MS Homo sapiens
91 LHX3  
Two-hybrid Homo sapiens
92 DCP1A 55802
Affinity Capture-MS Homo sapiens
93 BEND7 222389
Two-hybrid Homo sapiens
94 DLGAP3  
Two-hybrid Homo sapiens
95 MEOX2  
Two-hybrid Homo sapiens
96 TGM5  
Two-hybrid Homo sapiens
97 ZNF784  
Two-hybrid Homo sapiens
98 PRPF18  
Two-hybrid Homo sapiens
99 DYNLL2 140735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
100 PRKAR1B  
Two-hybrid Homo sapiens
101 MCCD1  
Two-hybrid Homo sapiens
102 PRPF31 26121
Two-hybrid Homo sapiens
103 HSPB8 26353
Affinity Capture-MS Homo sapiens
104 HERC2P9  
Affinity Capture-MS Homo sapiens
105 C17orf53  
Proximity Label-MS Homo sapiens
106 PHLPP1  
Proximity Label-MS Homo sapiens
107 ABI3 51225
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
108 ZFP57  
Two-hybrid Homo sapiens
109 C11orf1  
Two-hybrid Homo sapiens
110 PSEN1 5663
Two-hybrid Homo sapiens
111 AIFM1 9131
Affinity Capture-MS Homo sapiens
112 CEP63  
Two-hybrid Homo sapiens
113 TAX1BP1 8887
Two-hybrid Homo sapiens
114 TMOD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 XPO1 7514
Affinity Capture-MS Homo sapiens
116 MSS51  
Two-hybrid Homo sapiens
117 UBAP2 55833
Two-hybrid Homo sapiens
118 KRT86  
Two-hybrid Homo sapiens
119 STAC  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
120 NOS3  
Two-hybrid Homo sapiens
121 EPB41L4A 64097
Proximity Label-MS Homo sapiens
122 NUTM1  
Two-hybrid Homo sapiens
123 MAGEB4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
124 KRT75 9119
Two-hybrid Homo sapiens
125 SKP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 SYT6  
Two-hybrid Homo sapiens
127 STARD8  
Affinity Capture-MS Homo sapiens
128 GADD45GIP1  
Two-hybrid Homo sapiens
129 EIF4E 1977
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
130 ANKRD11 29123
Two-hybrid Homo sapiens
131 RIPK4  
Affinity Capture-MS Homo sapiens
132 MYOZ3  
Two-hybrid Homo sapiens
133 FN1 2335
Affinity Capture-MS Homo sapiens
134 KRT27 342574
Two-hybrid Homo sapiens
135 Anapc16  
Affinity Capture-MS Mus musculus
136 CRX  
Two-hybrid Homo sapiens
137 PLEKHA2 59339
Two-hybrid Homo sapiens
138 ZNF512  
Two-hybrid Homo sapiens
139 PSTPIP1 9051
Two-hybrid Homo sapiens
140 GEMIN4 50628
Two-hybrid Homo sapiens
141 COG6 57511
Two-hybrid Homo sapiens
142 L3MBTL3  
Two-hybrid Homo sapiens
143 FAM90A1  
Two-hybrid Homo sapiens
144 SEC16A 9919
Affinity Capture-MS Homo sapiens
145 SCARA5 286133
Two-hybrid Homo sapiens
146 HAND2  
Two-hybrid Homo sapiens
147 RAB11FIP2  
Two-hybrid Homo sapiens
148 TIFA  
Two-hybrid Homo sapiens
149 SORBS3 10174
Two-hybrid Homo sapiens
150 BICD1 636
Proximity Label-MS Homo sapiens
151 CUTC  
Two-hybrid Homo sapiens
152 Dynll1 56455
Affinity Capture-MS Mus musculus
153 USHBP1  
Two-hybrid Homo sapiens
154 CCDC96  
Affinity Capture-MS Homo sapiens
155 PELI3  
Affinity Capture-MS Homo sapiens
156 CDC20B  
Two-hybrid Homo sapiens
157 KRT19 3880
Proximity Label-MS Homo sapiens
158 FOXK1 221937
Affinity Capture-MS Homo sapiens
159 FHL2 2274
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
160 CAMK2G 818
Two-hybrid Homo sapiens
161 TSGA10  
Two-hybrid Homo sapiens
162 DNAJC6  
Proximity Label-MS Homo sapiens
163 TXLNA 200081
Two-hybrid Homo sapiens
164 GRK5 2869
Affinity Capture-MS Homo sapiens
165 PDLIM7 9260
Two-hybrid Homo sapiens
166 BIRC7  
Two-hybrid Homo sapiens
167 MED19  
Two-hybrid Homo sapiens
168 NAAA  
Affinity Capture-MS Homo sapiens
169 TFDP3  
Affinity Capture-MS Homo sapiens
170 TRAF2 7186
Two-hybrid Homo sapiens
171 PARP1 142
Proximity Label-MS Homo sapiens
172 EFHC2  
Two-hybrid Homo sapiens
173 THAP1  
Two-hybrid Homo sapiens
174 PRDM14  
Two-hybrid Homo sapiens
175 PLAGL2  
Two-hybrid Homo sapiens
176 VPS52 6293
Two-hybrid Homo sapiens
177 EZR 7430
Proximity Label-MS Homo sapiens
178 EGFL8  
Affinity Capture-MS Homo sapiens
179 BLZF1  
Two-hybrid Homo sapiens
180 RHOH  
Two-hybrid Homo sapiens
181 VMAC  
Two-hybrid Homo sapiens
182 SEPT9 10801
Proximity Label-MS Homo sapiens
183 UTP14C  
Two-hybrid Homo sapiens
184 NCOA2 10499
Affinity Capture-Western Homo sapiens
185 TSPYL6  
Two-hybrid Homo sapiens
186 MKRN3  
Two-hybrid Homo sapiens
187 CWF19L2  
Two-hybrid Homo sapiens
188 THAP6  
Two-hybrid Homo sapiens
189 SNAPIN 23557
Two-hybrid Homo sapiens
190 EDC3 80153
Affinity Capture-MS Homo sapiens
191 DDIT4L  
Two-hybrid Homo sapiens
192 GPANK1  
Two-hybrid Homo sapiens
193 PDE9A  
Two-hybrid Homo sapiens
194 GOLGA6L9  
Two-hybrid Homo sapiens
195 CHIC2 26511
Two-hybrid Homo sapiens
196 LBX1  
Two-hybrid Homo sapiens
197 CCDC36  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
198 PPP1CB 5500
Two-hybrid Homo sapiens
199 FAM161A  
Two-hybrid Homo sapiens
200 PXN 5829
Proximity Label-MS Homo sapiens
201 CBX8 57332
Two-hybrid Homo sapiens
202 HSPB2-C11orf52  
Two-hybrid Homo sapiens
203 KANK2 25959
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
204 TRIB3  
Two-hybrid Homo sapiens
205 KRTAP6-3  
Two-hybrid Homo sapiens
206 SNW1 22938
Two-hybrid Homo sapiens
207 LMO1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
208 MOB1A 55233
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
209 ZBTB42  
Two-hybrid Homo sapiens
210 HSF2BP  
Two-hybrid Homo sapiens
211 ZNF774  
Two-hybrid Homo sapiens
212 RBCK1  
Two-hybrid Homo sapiens
213 PRMT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
214 SERTAD3  
Two-hybrid Homo sapiens
215 C17orf59 54785
Two-hybrid Homo sapiens
216 EXOSC8  
Two-hybrid Homo sapiens
217 DYRK1A 1859
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KANK2 is involved
No pathways found





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