Gene description for PROZ
Gene name protein Z, vitamin K-dependent plasma glycoprotein
Gene symbol PROZ
Other names/aliases PZ
Species Homo sapiens
 Database cross references - PROZ
ExoCarta ExoCarta_8858
Entrez Gene 8858
HGNC 9460
MIM 176895
UniProt P22891  
 PROZ identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PROZ
Molecular Function
    serine-type endopeptidase activity GO:0004252 IEA
    calcium ion binding GO:0005509 IEA
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    proteolysis GO:0006508 TAS
    post-translational protein modification GO:0043687 TAS
    blood coagulation GO:0007596 IEA
    peptidyl-glutamic acid carboxylation GO:0017187 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
    Golgi lumen GO:0005796 TAS
 Experiment description of studies that identified PROZ in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PROZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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