Gene description for SEPN1
Gene name selenoprotein N, 1
Gene symbol SEPN1
Other names/aliases CFTD
MDRS1
RSMD1
RSS
SELN
Species Homo sapiens
 Database cross references - SEPN1
ExoCarta ExoCarta_57190
Vesiclepedia VP_57190
Entrez Gene 57190
HGNC 15999
MIM 606210
UniProt Q9NZV5  
 SEPN1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SEPN1
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 IEA
Biological Process
    respiratory system process GO:0003016 IEA
    energy reserve metabolic process GO:0006112 IEA
    mitochondrial calcium ion transmembrane transport GO:0006851 IEA
    mitochondrion organization GO:0007005 IEA
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    skeletal muscle satellite cell differentiation GO:0014816 IEA
    skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 IEA
    positive regulation of skeletal muscle cell proliferation GO:0014858 IEA
    response to muscle activity involved in regulation of muscle adaptation GO:0014873 IEA
    L-ascorbic acid transmembrane transport GO:0015882 IEA
    L-ascorbic acid metabolic process GO:0019852 IEA
    membrane to membrane docking GO:0022614 IEA
    collagen fibril organization GO:0030199 IEA
    multicellular organismal response to stress GO:0033555 IEA
    cellular response to oxidative stress GO:0034599 IEA
    membrane biogenesis GO:0044091 IEA
    ATP metabolic process GO:0046034 IEA
    lung alveolus development GO:0048286 IEA
    skeletal muscle fiber development GO:0048741 IBA
    calcium ion homeostasis GO:0055074 IBA
    calcium ion homeostasis GO:0055074 IMP
    regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 IMP
    membrane organization GO:0061024 IEA
    cellular response to caffeine GO:0071313 IEA
    positive regulation of response to oxidative stress GO:1902884 IMP
    mitochondrion-endoplasmic reticulum membrane tethering GO:1990456 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    mitochondrial membrane GO:0031966 IEA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IEA
 Experiment description of studies that identified SEPN1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SEPN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYZL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 EMR4P  
Affinity Capture-MS Homo sapiens
3 GALNT10 55568
Affinity Capture-MS Homo sapiens
4 FEZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 GPIHBP1  
Affinity Capture-MS Homo sapiens
6 CABP2  
Affinity Capture-MS Homo sapiens
7 TMEM106A  
Affinity Capture-MS Homo sapiens
8 CHST5  
Affinity Capture-MS Homo sapiens
9 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
10 SIAE 54414
Affinity Capture-MS Homo sapiens
11 EMILIN3  
Affinity Capture-MS Homo sapiens
12 TDRKH  
Affinity Capture-MS Homo sapiens
13 NMB  
Affinity Capture-MS Homo sapiens
14 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CHST8 64377
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 B3GNT3 10331
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 HS3ST2  
Affinity Capture-MS Homo sapiens
20 EMID1  
Affinity Capture-MS Homo sapiens
21 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SAAL1 113174
Affinity Capture-MS Homo sapiens
23 ECEL1  
Affinity Capture-MS Homo sapiens
24 MFAP4 4239
Affinity Capture-MS Homo sapiens
25 NPTXR 23467
Affinity Capture-MS Homo sapiens
26 ARL2BP 23568
Affinity Capture-MS Homo sapiens
27 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
28 TREX2  
Affinity Capture-MS Homo sapiens
29 LYZL1  
Affinity Capture-MS Homo sapiens
30 CNPY3 10695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 OS9 10956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GPRC5D  
Affinity Capture-MS Homo sapiens
33 TMEM169  
Affinity Capture-MS Homo sapiens
34 MFAP5  
Affinity Capture-MS Homo sapiens
35 DEFB136  
Affinity Capture-MS Homo sapiens
36 PROZ 8858
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PLD3 23646
Affinity Capture-MS Homo sapiens
38 SIRPD  
Affinity Capture-MS Homo sapiens
39 LACRT 90070
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 HLA-DRB3 3125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SDF2L1 23753
Affinity Capture-MS Homo sapiens
42 FBXO2 26232
Affinity Capture-MS Homo sapiens
43 SCGB2A2  
Affinity Capture-MS Homo sapiens
44 C1orf54  
Affinity Capture-MS Homo sapiens
45 PSCA 8000
Affinity Capture-MS Homo sapiens
46 NCEH1 57552
Affinity Capture-MS Homo sapiens
47 DHH  
Affinity Capture-MS Homo sapiens
48 B3GAT2  
Affinity Capture-MS Homo sapiens
49 GXYLT1 283464
Affinity Capture-MS Homo sapiens
50 WDR5B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ACTL6B  
Affinity Capture-MS Homo sapiens
52 EDN3  
Affinity Capture-MS Homo sapiens
53 NXPH3  
Affinity Capture-MS Homo sapiens
54 NCR3  
Affinity Capture-MS Homo sapiens
55 ST8SIA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 PBXIP1 57326
Affinity Capture-MS Homo sapiens
57 IL5RA  
Affinity Capture-MS Homo sapiens
58 CFC1  
Affinity Capture-MS Homo sapiens
59 KLK15  
Affinity Capture-MS Homo sapiens
60 PLD4  
Affinity Capture-MS Homo sapiens
61 TCF25 22980
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SEPN1 is involved
No pathways found





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