Gene description for TCF25
Gene name transcription factor 25 (basic helix-loop-helix)
Gene symbol TCF25
Other names/aliases FKSG26
Hulp1
NULP1
PRO2620
hKIAA1049
Species Homo sapiens
 Database cross references - TCF25
ExoCarta ExoCarta_22980
Vesiclepedia VP_22980
Entrez Gene 22980
HGNC 29181
MIM 612326
UniProt Q9BQ70  
 TCF25 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TCF25
Molecular Function
    DNA binding GO:0003677 IEA
    transcription corepressor activity GO:0003714 IDA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    heart development GO:0007507 NAS
    regulation of protein K48-linked ubiquitination GO:0061945 IDA
    rescue of stalled ribosome GO:0072344 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IEA
    RQC complex GO:1990112 IBA
    RQC complex GO:1990112 IDA
 Experiment description of studies that identified TCF25 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TCF25
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAB 7529
Affinity Capture-MS Homo sapiens
2 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 HECTD1 25831
Affinity Capture-MS Homo sapiens
4 BCKDHB 594
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 C2CD4B  
Affinity Capture-MS Homo sapiens
6 SHPK 23729
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SENP3 26168
Affinity Capture-MS Homo sapiens
8 HUWE1 10075
Affinity Capture-MS Homo sapiens
9 MRPL4 51073
Affinity Capture-MS Homo sapiens
10 XIAP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
11 AMD1  
Affinity Capture-MS Homo sapiens
12 OBSL1 23363
Affinity Capture-MS Homo sapiens
13 RBM14 10432
Affinity Capture-MS Homo sapiens
14 MSH2 4436
Co-fractionation Homo sapiens
15 RPS2 6187
Affinity Capture-MS Homo sapiens
16 XPO1 7514
Affinity Capture-MS Homo sapiens
17 AGO1  
Affinity Capture-MS Homo sapiens
18 RC3H2  
Affinity Capture-MS Homo sapiens
19 YWHAE 7531
Affinity Capture-MS Homo sapiens
20 MEN1 4221
Affinity Capture-MS Homo sapiens
21 LIPA 3988
Affinity Capture-MS Homo sapiens
22 FOXA1  
Affinity Capture-MS Homo sapiens
23 MAGEA11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 USP9X 8239
Affinity Capture-MS Homo sapiens
25 USP7 7874
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ADAMTS13 11093
Affinity Capture-MS Homo sapiens
27 PARK2  
Affinity Capture-MS Homo sapiens
28 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
29 RPS10 6204
Two-hybrid Homo sapiens
30 DDX58 23586
Affinity Capture-RNA Homo sapiens
31 RIPK4  
Affinity Capture-MS Homo sapiens
32 GPRASP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 APPBP2  
Two-hybrid Homo sapiens
34 CTSG 1511
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 C9orf78 51759
Affinity Capture-MS Homo sapiens
36 CCDC155  
Two-hybrid Homo sapiens
37 NEK2  
Two-hybrid Homo sapiens
38 KIAA1683  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 XPNPEP3 63929
Affinity Capture-MS Homo sapiens
40 YWHAZ 7534
Affinity Capture-MS Homo sapiens
41 RPA3 6119
Proximity Label-MS Homo sapiens
42 C16orf72 29035
Affinity Capture-MS Homo sapiens
43 TRIM31  
Affinity Capture-MS Homo sapiens
44 PINK1  
Affinity Capture-MS Homo sapiens
45 ACTR3 10096
Proximity Label-MS Homo sapiens
46 TSNAX 7257
Affinity Capture-MS Homo sapiens
47 Rrbp1  
Affinity Capture-MS Mus musculus
48 Htatsf1  
Two-hybrid Mus musculus
49 FBXW7  
Affinity Capture-MS Homo sapiens
50 TULP3 7289
Affinity Capture-MS Homo sapiens
51 PPAN 56342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 DDRGK1 65992
Affinity Capture-MS Homo sapiens
53 BRPF3  
Affinity Capture-MS Homo sapiens
54 YWHAG 7532
Affinity Capture-MS Homo sapiens
55 GPX7 2882
Two-hybrid Homo sapiens
56 AAMP 14
Affinity Capture-MS Homo sapiens
57 BCKDHA 593
Affinity Capture-MS Homo sapiens
58 SAT1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
59 SEPN1 57190
Affinity Capture-MS Homo sapiens
60 DCAF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 KLHL2 11275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 DERL1 79139
Two-hybrid Homo sapiens
63 STAM 8027
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TCF25 is involved
No pathways found





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