Gene description for ADAMTS13
Gene name ADAM metallopeptidase with thrombospondin type 1 motif, 13
Gene symbol ADAMTS13
Other names/aliases ADAM-TS13
ADAMTS-13
C9orf8
VWFCP
vWF-CP
Species Homo sapiens
 Database cross references - ADAMTS13
ExoCarta ExoCarta_11093
Entrez Gene 11093
HGNC 1366
MIM 604134
UniProt Q76LX8  
 ADAMTS13 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for ADAMTS13
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    integrin binding GO:0005178 TAS
    metallopeptidase activity GO:0008237 TAS
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 TAS
    zinc ion binding GO:0008270 TAS
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    response to interleukin-4 GO:0070670 IEA
    protein O-linked fucosylation GO:0036066 TAS
    platelet activation GO:0030168 NAS
    integrin-mediated signaling pathway GO:0007229 NAS
    response to interferon-gamma GO:0034341 IEA
    glycoprotein metabolic process GO:0009100 NAS
    response to toxic substance GO:0009636 IEA
    post-translational protein modification GO:0043687 TAS
    peptide catabolic process GO:0043171 IDA
    cell-matrix adhesion GO:0007160 NAS
    response to tumor necrosis factor GO:0034612 IEA
    protein processing GO:0016485 TAS
    protein O-linked glycosylation GO:0006493 TAS
    proteolysis GO:0006508 IDA
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 TAS
    cell surface GO:0009986 NAS
    extracellular space GO:0005615 IEA
    endoplasmic reticulum lumen GO:0005788 TAS
 Experiment description of studies that identified ADAMTS13 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for ADAMTS13
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADAMTS13 is involved
PathwayEvidenceSource
O-glycosylation of TSR domain-containing proteins TAS Reactome





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