Gene description for FREM2
Gene name FRAS1 related extracellular matrix protein 2
Gene symbol FREM2
Other names/aliases -
Species Homo sapiens
 Database cross references - FREM2
ExoCarta ExoCarta_341640
Entrez Gene 341640
HGNC 25396
MIM 608945
UniProt Q5SZK8  
 FREM2 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for FREM2
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    morphogenesis of an epithelium GO:0002009 IEA
    cell communication GO:0007154 IEA
    inner ear development GO:0048839 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 IDA
    basement membrane GO:0005604 IEA
 Experiment description of studies that identified FREM2 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FREM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FREM2 is involved
No pathways found





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