Gene description for FREM2
Gene name FRAS1 related extracellular matrix protein 2
Gene symbol FREM2
Other names/aliases -
Species Homo sapiens
 Database cross references - FREM2
ExoCarta ExoCarta_341640
Vesiclepedia VP_341640
Entrez Gene 341640
HGNC 25396
MIM 608945
UniProt Q5SZK8  
 FREM2 identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for FREM2
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    eye development GO:0001654 IMP
    kidney development GO:0001822 IEA
    morphogenesis of an epithelium GO:0002009 IEA
    cell communication GO:0007154 IEA
    cell adhesion GO:0007155 IMP
    heart development GO:0007507 IEA
    anatomical structure morphogenesis GO:0009653 IBA
    embryonic digit morphogenesis GO:0042733 IEA
    inner ear development GO:0048839 IEA
Subcellular Localization
    basement membrane GO:0005604 IEA
    plasma membrane GO:0005886 IEA
    collagen-containing extracellular matrix GO:0062023 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified FREM2 in sEVs
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FREM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAM19A5 25817
Affinity Capture-MS Homo sapiens
2 FCGR1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 BAGE2  
Affinity Capture-MS Homo sapiens
4 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ZBBX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CEACAM8 1088
Affinity Capture-MS Homo sapiens
7 PDGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 LIPH 200879
Affinity Capture-MS Homo sapiens
9 SCGB1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 KLK5 25818
Affinity Capture-MS Homo sapiens
11 CALR3  
Affinity Capture-MS Homo sapiens
12 TNF  
Affinity Capture-MS Homo sapiens
13 TAZ  
Affinity Capture-MS Homo sapiens
14 DNASE2B  
Affinity Capture-MS Homo sapiens
15 CHST8 64377
Affinity Capture-MS Homo sapiens
16 FAM19A4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 RYK 6259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LECT2  
Affinity Capture-MS Homo sapiens
19 LGALS1 3956
Affinity Capture-MS Homo sapiens
20 C2CD4B  
Affinity Capture-MS Homo sapiens
21 LOC254896  
Affinity Capture-MS Homo sapiens
22 ADAMTS13 11093
Affinity Capture-MS Homo sapiens
23 TRIM68 55128
Affinity Capture-MS Homo sapiens
24 UCN3  
Affinity Capture-MS Homo sapiens
25 HNRNPK 3190
Cross-Linking-MS (XL-MS) Homo sapiens
26 CTSG 1511
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 DDX39A 10212
Affinity Capture-MS Homo sapiens
28 DCANP1  
Affinity Capture-MS Homo sapiens
29 CMA1  
Affinity Capture-MS Homo sapiens
30 WDR76  
Affinity Capture-MS Homo sapiens
31 SEC61B 10952
Proximity Label-MS Homo sapiens
32 LAG3  
Affinity Capture-MS Homo sapiens
33 NXPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 DEFA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 XAGE1B  
Affinity Capture-MS Homo sapiens
36 RPL28 6158
Affinity Capture-MS Homo sapiens
37 HYOU1 10525
Affinity Capture-MS Homo sapiens
38 DTWD2  
Affinity Capture-MS Homo sapiens
39 FAM19A2 338811
Affinity Capture-MS Homo sapiens
40 ARNTL2  
Affinity Capture-MS Homo sapiens
41 MRPS17 51373
Affinity Capture-MS Homo sapiens
42 INSL6  
Affinity Capture-MS Homo sapiens
43 POLR2A 5430
Affinity Capture-MS Homo sapiens
44 TIMP3 7078
Affinity Capture-MS Homo sapiens
45 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ADAMTS17  
Affinity Capture-MS Homo sapiens
47 PSG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CXCL16 58191
Affinity Capture-MS Homo sapiens
49 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FREM2 is involved
No pathways found





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