Gene description for TRIM68
Gene name tripartite motif containing 68
Gene symbol TRIM68
Other names/aliases GC109
RNF137
SS-56
SS56
Species Homo sapiens
 Database cross references - TRIM68
ExoCarta ExoCarta_55128
Entrez Gene 55128
HGNC 21161
MIM 613184
UniProt Q6AZZ1  
 TRIM68 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TRIM68
Molecular Function
    zinc ion binding GO:0008270 IEA
    ubiquitin-protein transferase activity GO:0004842 IDA
    histone acetyltransferase binding GO:0035035 IPI
    ligase activity GO:0016874 IEA
    androgen receptor binding GO:0050681 IPI
Biological Process
    protein autoubiquitination GO:0051865 IDA
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    regulation of androgen receptor signaling pathway GO:0060765 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    Golgi apparatus GO:0005794 IDA
    nucleolus GO:0005730 IDA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TRIM68 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TRIM68
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRIM68 is involved
PathwayEvidenceSource
Interferon gamma signaling TAS Reactome





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