Gene description for TRIM68
Gene name tripartite motif containing 68
Gene symbol TRIM68
Other names/aliases GC109
RNF137
SS-56
SS56
Species Homo sapiens
 Database cross references - TRIM68
ExoCarta ExoCarta_55128
Vesiclepedia VP_55128
Entrez Gene 55128
HGNC 21161
MIM 613184
UniProt Q6AZZ1  
 TRIM68 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TRIM68
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    histone acetyltransferase binding GO:0035035 IPI
    identical protein binding GO:0042802 IPI
    nuclear androgen receptor binding GO:0050681 IPI
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    regulation of gene expression GO:0010468 IBA
    innate immune response GO:0045087 IBA
    protein autoubiquitination GO:0051865 IDA
    regulation of androgen receptor signaling pathway GO:0060765 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified TRIM68 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TRIM68
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RBM38  
Affinity Capture-MS Homo sapiens
2 POLR2G 5436
Two-hybrid Homo sapiens
3 GRAP2 9402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CCT3 7203
Affinity Capture-MS Homo sapiens
5 FBN2 2201
Affinity Capture-MS Homo sapiens
6 BTN1A1 696
Affinity Capture-MS Homo sapiens
7 MMP28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TCTN3  
Affinity Capture-MS Homo sapiens
9 REL 5966
Two-hybrid Homo sapiens
10 HOXA9  
Affinity Capture-MS Homo sapiens
11 CCT4 10575
Affinity Capture-MS Homo sapiens
12 CCT6B 10693
Affinity Capture-MS Homo sapiens
13 SCAF4 57466
Affinity Capture-MS Homo sapiens
14 BTN3A3 10384
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 KRTAP13-2  
Two-hybrid Homo sapiens
16 CTGF 1490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 BTN3A1 11119
Affinity Capture-MS Homo sapiens
18 SMR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 VEGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 KHDRBS1 10657
Affinity Capture-MS Homo sapiens
21 PRELP 5549
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 P3H1 64175
Affinity Capture-MS Homo sapiens
23 FZD7 8324
Affinity Capture-MS Homo sapiens
24 NUDT16L1 84309
Two-hybrid Homo sapiens
25 FAM20C 56975
Affinity Capture-MS Homo sapiens
26 KIF14 9928
Affinity Capture-MS Homo sapiens
27 FAM163A  
Affinity Capture-MS Homo sapiens
28 CCT2 10576
Affinity Capture-MS Homo sapiens
29 LZTFL1 54585
Two-hybrid Homo sapiens
30 TCP1 6950
Affinity Capture-MS Homo sapiens
31 HSP90B1 7184
Affinity Capture-MS Homo sapiens
32 CCT5 22948
Affinity Capture-MS Homo sapiens
33 PRSS48 345062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MMAB 326625
Affinity Capture-MS Homo sapiens
35 NTF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 PILRA 29992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 CCK  
Affinity Capture-MS Homo sapiens
38 LENG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 COLQ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 GNRH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 UBE2D3 7323
Reconstituted Complex Homo sapiens
42 HGFAC 3083
Affinity Capture-MS Homo sapiens
43 C1QTNF7  
Affinity Capture-MS Homo sapiens
44 WISP2 8839
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 GPS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CRELD1 78987
Affinity Capture-MS Homo sapiens
47 ARHGAP17 55114
Affinity Capture-MS Homo sapiens
48 DISC1 27185
Two-hybrid Homo sapiens
49 SFPQ 6421
Affinity Capture-MS Homo sapiens
50 COLEC11 78989
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 C1orf105  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 AHDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 CCT6A 908
Affinity Capture-MS Homo sapiens
54 IFI30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CD6 923
Affinity Capture-MS Homo sapiens
56 TJP1 7082
Affinity Capture-MS Homo sapiens
57 CUL3 8452
Affinity Capture-MS Homo sapiens
58 TMEM139  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TRIM68 55128
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
60 GJA3  
Affinity Capture-MS Homo sapiens
61 NRP2 8828
Affinity Capture-MS Homo sapiens
62 PGLYRP3 114771
Affinity Capture-MS Homo sapiens
63 GCNT2 2651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 ACRV1  
Affinity Capture-MS Homo sapiens
65 NLRP1  
Affinity Capture-MS Homo sapiens
66 AUNIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 KAT5  
Affinity Capture-Western Homo sapiens
68 RAI1 10743
Affinity Capture-MS Homo sapiens
69 DMRT1  
Affinity Capture-MS Homo sapiens
70 AGFG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 THSD4 79875
Affinity Capture-MS Homo sapiens
72 ENTHD2  
Two-hybrid Homo sapiens
73 UBE2U  
Two-hybrid Homo sapiens
74 CPXM2 119587
Affinity Capture-MS Homo sapiens
75 FBLN5 10516
Affinity Capture-MS Homo sapiens
76 STUB1 10273
Affinity Capture-MS Homo sapiens
77 TFG 10342
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
78 LOXL1 4016
Affinity Capture-MS Homo sapiens
79 PPAP2A 8611
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CCT8 10694
Affinity Capture-MS Homo sapiens
81 IGLL5 100423062
Affinity Capture-MS Homo sapiens
82 INCA1  
Two-hybrid Homo sapiens
83 FREM2 341640
Affinity Capture-MS Homo sapiens
84 APOC4  
Affinity Capture-MS Homo sapiens
85 CCT7 10574
Affinity Capture-MS Homo sapiens
86 FOLR3  
Affinity Capture-MS Homo sapiens
87 TCF4  
Two-hybrid Homo sapiens
88 HNRNPL 3191
Affinity Capture-MS Homo sapiens
89 LAMB2 3913
Affinity Capture-MS Homo sapiens
90 GPC3 2719
Affinity Capture-MS Homo sapiens
91 C1orf21  
Affinity Capture-MS Homo sapiens
92 ECM1 1893
Affinity Capture-MS Homo sapiens
93 AR 367
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 KRTAP13-3  
Two-hybrid Homo sapiens
95 LTBP2 4053
Affinity Capture-MS Homo sapiens
96 ZBTB42  
Two-hybrid Homo sapiens
97 VIM 7431
Affinity Capture-MS Homo sapiens
98 CCL16  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TRIM68 is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system TAS Reactome
Immune System TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome





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