Gene description for PPAP2A
Gene name phosphatidic acid phosphatase type 2A
Gene symbol PPAP2A
Other names/aliases LLP1a
LPP1
PAP-2a
PAP2
Species Homo sapiens
 Database cross references - PPAP2A
ExoCarta ExoCarta_8611
Entrez Gene 8611
HGNC 9228
MIM 607124
UniProt O14494  
 PPAP2A identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PPAP2A
Molecular Function
    phosphatidate phosphatase activity GO:0008195 NAS
Biological Process
    regulation of lipid metabolic process GO:0019216 NAS
    phospholipid dephosphorylation GO:0046839 TAS
    negative regulation of cell proliferation GO:0008285 NAS
    androgen receptor signaling pathway GO:0030521 NAS
    germ cell migration GO:0008354 TAS
    sphingolipid biosynthetic process GO:0030148 TAS
    protein dephosphorylation GO:0006470 IEA
    lipid metabolic process GO:0006629 NAS
    intracellular steroid hormone receptor signaling pathway GO:0030518 TAS
    sphingolipid metabolic process GO:0006665 TAS
    small molecule metabolic process GO:0044281 TAS
    protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 NAS
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
 Experiment description of studies that identified PPAP2A in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PPAP2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FXYD1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which PPAP2A is involved
PathwayEvidenceSource
Sphingolipid de novo biosynthesis TAS Reactome





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