Gene description for RAI1
Gene name retinoic acid induced 1
Gene symbol RAI1
Other names/aliases SMCR
SMS
Species Homo sapiens
 Database cross references - RAI1
ExoCarta ExoCarta_10743
Entrez Gene 10743
HGNC 9834
MIM 607642
UniProt Q7Z5J4  
 RAI1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RAI1
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    enhancer binding GO:0035326 IDA
Biological Process
    negative regulation of multicellular organism growth GO:0040015 IEA
    circadian regulation of gene expression GO:0032922 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    skeletal system development GO:0001501 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified RAI1 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RAI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PIN1 5300
Two-hybrid Homo sapiens
2 TESC 54997
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RAI1 is involved
PathwayEvidenceSource
Circadian Clock TAS Reactome





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