Gene description for RPS6KA5
Gene name ribosomal protein S6 kinase, 90kDa, polypeptide 5
Gene symbol RPS6KA5
Other names/aliases MSK1
MSPK1
RLPK
Species Homo sapiens
 Database cross references - RPS6KA5
ExoCarta ExoCarta_9252
Entrez Gene 9252
HGNC 10434
MIM 603607
UniProt O75582  
 RPS6KA5 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for RPS6KA5
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IMP
    protein kinase activity GO:0004672 IDA
    magnesium ion binding GO:0000287 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
Biological Process
    intracellular signal transduction GO:0035556 IDA
    protein phosphorylation GO:0006468 IDA
    positive regulation of histone phosphorylation GO:0033129 IMP
    positive regulation of CREB transcription factor activity GO:0032793 TAS
    axon guidance GO:0007411 TAS
    toll-like receptor 4 signaling pathway GO:0034142 TAS
    positive regulation of histone acetylation GO:0035066 IMP
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    toll-like receptor 3 signaling pathway GO:0034138 TAS
    inflammatory response GO:0006954 IEA
    innate immune response GO:0045087 TAS
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    negative regulation of cytokine production GO:0001818 TAS
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS
    histone H3-S28 phosphorylation GO:0043988 IMP
    toll-like receptor 10 signaling pathway GO:0034166 TAS
    regulation of transcription, DNA-templated GO:0006355 IMP
    toll-like receptor signaling pathway GO:0002224 TAS
    MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    toll-like receptor 2 signaling pathway GO:0034134 TAS
    toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS
    toll-like receptor 9 signaling pathway GO:0034162 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    interleukin-1-mediated signaling pathway GO:0070498 IMP
    toll-like receptor 5 signaling pathway GO:0034146 TAS
    histone H2A-S1 phosphorylation GO:0043990 IDA
    stress-activated MAPK cascade GO:0051403 TAS
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS
    histone phosphorylation GO:0016572 TAS
    histone H3-S10 phosphorylation GO:0043987 IMP
    toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IMP
 Experiment description of studies that identified RPS6KA5 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RPS6KA5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK1 5594
Phenotypic Enhancement Homo sapiens
2 EGF 1950
Phenotypic Enhancement Homo sapiens
3 CREB1  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
4 BAD  
Reconstituted Complex Homo sapiens
5 MAPK11  
Phenotypic Enhancement Homo sapiens
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