Gene description for ROBO2
Gene name roundabout, axon guidance receptor, homolog 2 (Drosophila)
Gene symbol ROBO2
Other names/aliases SAX3
Species Homo sapiens
 Database cross references - ROBO2
ExoCarta ExoCarta_6092
Entrez Gene 6092
HGNC 10250
MIM 602431
UniProt Q9HCK4  
 ROBO2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ROBO2
Molecular Function
    axon guidance receptor activity GO:0008046 NAS
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IDA
Biological Process
    axon guidance GO:0007411 TAS
    cellular response to hormone stimulus GO:0032870 IEP
    olfactory bulb interneuron development GO:0021891 ISS
    axon midline choice point recognition GO:0016199 ISS
    brain development GO:0007420 IEP
    retinal ganglion cell axon guidance GO:0031290 ISS
    apoptotic process involved in luteolysis GO:0061364 IEP
    positive regulation of axonogenesis GO:0050772 IDA
    negative regulation of negative chemotaxis GO:0050925 IDA
    ureteric bud development GO:0001657 IMP
    metanephros development GO:0001656 ISS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IDA
    central nervous system development GO:0007417 NAS
    negative regulation of synapse assembly GO:0051964 ISS
Subcellular Localization
    cell surface GO:0009986 IDA
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 IDA
    axolemma GO:0030673 ISS
 Experiment description of studies that identified ROBO2 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ROBO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLIT2 9353
Invivo Homo sapiens
Invitro Homo sapiens
2 SLIT3  
Invitro Homo sapiens
Invivo Homo sapiens
3 CPE  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ROBO2 is involved
PathwayEvidenceSource
Regulation of Commissural axon pathfinding by Slit and Robo TAS Reactome





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