Gene description for TMEM248
Gene name transmembrane protein 248
Gene symbol TMEM248
Other names/aliases C7orf42
Species Homo sapiens
 Database cross references - TMEM248
ExoCarta ExoCarta_55069
Vesiclepedia VP_55069
Entrez Gene 55069
HGNC 25476
UniProt Q9NWD8  
 TMEM248 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM248
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified TMEM248 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM248
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM239  
Two-hybrid Homo sapiens
2 PZP 5858
Affinity Capture-MS Homo sapiens
3 KIF21B 23046
Affinity Capture-MS Homo sapiens
4 RRM2 6241
Affinity Capture-MS Homo sapiens
5 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
6 RXFP3  
Two-hybrid Homo sapiens
7 UQCRQ 27089
Affinity Capture-MS Homo sapiens
8 LEPROTL1 23484
Two-hybrid Homo sapiens
9 CANX 821
Affinity Capture-MS Homo sapiens
10 GPR37L1  
Two-hybrid Homo sapiens
11 TUSC5  
Two-hybrid Homo sapiens
12 TMEM147 10430
Two-hybrid Homo sapiens
13 FAM3C 10447
Two-hybrid Homo sapiens
14 GPR25  
Two-hybrid Homo sapiens
15 SYNE4  
Two-hybrid Homo sapiens
16 VSTM1  
Two-hybrid Homo sapiens
17 ARL6IP1 23204
Two-hybrid Homo sapiens
18 TAF1  
Affinity Capture-MS Homo sapiens
19 CCDC93 54520
Affinity Capture-MS Homo sapiens
20 MAL  
Two-hybrid Homo sapiens
21 SSH3 54961
Affinity Capture-MS Homo sapiens
22 AUP1 550
Affinity Capture-MS Homo sapiens
23 SLC35B2 347734
Two-hybrid Homo sapiens
24 TMEM86B  
Two-hybrid Homo sapiens
25 TSPAN5 10098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 UBFD1 56061
Affinity Capture-MS Homo sapiens
27 BRICD5  
Two-hybrid Homo sapiens
28 BCL7B  
Affinity Capture-MS Homo sapiens
29 C16orf58 64755
Two-hybrid Homo sapiens
30 BARD1 580
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
31 ROBO2 6092
Affinity Capture-MS Homo sapiens
32 ASTE1  
Affinity Capture-MS Homo sapiens
33 GRM2 2912
Two-hybrid Homo sapiens
34 SLC41A1 254428
Two-hybrid Homo sapiens
35 C4orf3  
Two-hybrid Homo sapiens
36 LACRT 90070
Affinity Capture-MS Homo sapiens
37 PKD2 5311
Affinity Capture-MS Homo sapiens
38 ABCA2 20
Affinity Capture-MS Homo sapiens
39 SYS1  
Two-hybrid Homo sapiens
40 ANKRD46 157567
Two-hybrid Homo sapiens
41 CLDN19  
Two-hybrid Homo sapiens
42 YIF1A 10897
Two-hybrid Homo sapiens
43 LHFPL5  
Two-hybrid Homo sapiens
44 CEP162  
Affinity Capture-MS Homo sapiens
45 MALL  
Two-hybrid Homo sapiens
46 VPS4A 27183
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM248 is involved
No pathways found





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