Gene description for LACRT
Gene name lacritin
Gene symbol LACRT
Other names/aliases -
Species Homo sapiens
 Database cross references - LACRT
ExoCarta ExoCarta_90070
Vesiclepedia VP_90070
Entrez Gene 90070
HGNC 16430
MIM 607360
UniProt Q9GZZ8  
 LACRT identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for LACRT
Molecular Function
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 IDA
    growth factor activity GO:0008083 IDA
    laminin-1 binding GO:0043237 IDA
Biological Process
    positive regulation of cell population proliferation GO:0008284 IBA
    positive regulation of cell population proliferation GO:0008284 IDA
    epithelial structure maintenance GO:0010669 IDA
    positive regulation of macroautophagy GO:0016239 IDA
    calcium-mediated signaling GO:0019722 IBA
    calcium-mediated signaling GO:0019722 IDA
    negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 IDA
    calcineurin-NFAT signaling cascade GO:0033173 IDA
    protein localization to Golgi apparatus GO:0034067 IDA
    defense response to bacterium GO:0042742 IDA
    negative regulation of apoptotic process GO:0043066 IDA
    positive regulation of epithelial cell proliferation GO:0050679 IDA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    positive regulation of calcium-mediated signaling GO:0050850 IDA
    positive regulation of secretion GO:0051047 IBA
    positive regulation of secretion GO:0051047 IDA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IDA
    positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 IDA
    tear secretion GO:0070075 IDA
    tear secretion GO:0070075 NAS
    positive regulation of calcineurin-NFAT signaling cascade GO:0070886 IDA
Subcellular Localization
    extracellular region GO:0005576 IBA
    extracellular region GO:0005576 IDA
    extracellular space GO:0005615 HDA
    secretory granule GO:0030141 IBA
    secretory granule GO:0030141 IDA
 Experiment description of studies that identified LACRT in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for LACRT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 WDFY3 23001
Affinity Capture-MS Homo sapiens
2 RNGTT 8732
Affinity Capture-MS Homo sapiens
3 PLXNA2 5362
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CASP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 THUMPD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 GNMT 27232
Affinity Capture-MS Homo sapiens
8 PPP1R3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 OR13C3  
Affinity Capture-MS Homo sapiens
10 SEPN1 57190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NDST2  
Affinity Capture-MS Homo sapiens
12 RAD23A 5886
Affinity Capture-MS Homo sapiens
13 KIF14 9928
Affinity Capture-MS Homo sapiens
14 GOLGA8A 23015
Affinity Capture-MS Homo sapiens
15 SDC1 6382
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
16 WWOX 51741
Affinity Capture-MS Homo sapiens
17 VTN 7448
Reconstituted Complex Homo sapiens
18 DDX3X 1654
Affinity Capture-MS Homo sapiens
19 TMEM176B 28959
Affinity Capture-MS Homo sapiens
20 TMEM248 55069
Affinity Capture-MS Homo sapiens
21 C22orf31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PRAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 NID1 4811
Reconstituted Complex Homo sapiens
25 SLC25A10 1468
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 EMC4 51234
Affinity Capture-MS Homo sapiens
27 RNF114 55905
Affinity Capture-MS Homo sapiens
28 FN1 2335
Reconstituted Complex Homo sapiens
29 ERO1L 30001
Affinity Capture-MS Homo sapiens
30 PCK2 5106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PMEPA1 56937
Affinity Capture-MS Homo sapiens
32 SFXN4  
Affinity Capture-MS Homo sapiens
33 DHRS12  
Affinity Capture-MS Homo sapiens
34 TGM2 7052
Reconstituted Complex Homo sapiens
35 KATNA1 11104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 DLX6  
Affinity Capture-MS Homo sapiens
37 SPNS3  
Affinity Capture-MS Homo sapiens
38 TMEM74  
Affinity Capture-MS Homo sapiens
39 APP 351
Reconstituted Complex Homo sapiens
40 CCDC148  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 FKBP14  
Affinity Capture-MS Homo sapiens
42 RSPO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 DUSP13  
Affinity Capture-MS Homo sapiens
44 HYOU1 10525
Affinity Capture-MS Homo sapiens
45 PPCS 79717
Affinity Capture-MS Homo sapiens
46 ZNF691  
Affinity Capture-MS Homo sapiens
47 DUSP12 11266
Affinity Capture-MS Homo sapiens
48 KIAA0319L 79932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 KLK10 5655
Affinity Capture-MS Homo sapiens
50 HECW2  
Affinity Capture-MS Homo sapiens
51 FN3KRP 79672
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 ITLN2  
Affinity Capture-MS Homo sapiens
53 PCCB 5096
Affinity Capture-MS Homo sapiens
54 SMAD3 4088
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 HBM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ACOX1 51
Affinity Capture-MS Homo sapiens
57 NEUROD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 ALDH3B1 221
Affinity Capture-MS Homo sapiens
59 PYCRL 65263
Affinity Capture-MS Homo sapiens
60 KCNIP4 80333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 POLL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 SLC2A6 11182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 GOLM1 51280
Affinity Capture-MS Homo sapiens
64 ATP11C 286410
Affinity Capture-MS Homo sapiens
65 NTSR1  
Affinity Capture-MS Homo sapiens
66 ARSK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 FAM166B  
Affinity Capture-MS Homo sapiens
68 TTLL9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 CLCN2  
Affinity Capture-MS Homo sapiens
70 LRRC8E 80131
Affinity Capture-MS Homo sapiens
71 GJB5  
Affinity Capture-MS Homo sapiens
72 GIP  
Affinity Capture-MS Homo sapiens
73 PCYOX1L 78991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LACRT is involved
No pathways found





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