Gene description for PLXNA2
Gene name plexin A2
Gene symbol PLXNA2
Other names/aliases OCT
PLXN2
Species Homo sapiens
 Database cross references - PLXNA2
ExoCarta ExoCarta_5362
Entrez Gene 5362
HGNC 9100
MIM 601054
UniProt O75051  
 PLXNA2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Neuroblastoma cells 25944692    
 Gene ontology annotations for PLXNA2
Molecular Function
    protein binding GO:0005515 IPI
    semaphorin receptor activity GO:0017154 ISS
Biological Process
    regulation of cell migration GO:0030334 ISS
    centrosome localization GO:0051642 IEA
    axon guidance GO:0007411 TAS
    neural tube development GO:0021915 IEA
    cerebellar granule cell precursor tangential migration GO:0021935 IEA
    somitogenesis GO:0001756 IEA
    limb bud formation GO:0060174 IEA
    pharyngeal system development GO:0060037 IEA
    semaphorin-plexin signaling pathway GO:0071526 ISS
Subcellular Localization
    integral component of plasma membrane GO:0005887 ISS
    semaphorin receptor complex GO:0002116 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified PLXNA2 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PLXNA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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