Gene description for DEFA1
Gene name	defensin, alpha 1
Gene symbol	DEFA1
Other names/aliases	DEF1 DEFA2 HNP-1 HP-1 HP1 MRS
Species	Homo sapiens
Database cross references - DEFA1
ExoCarta	ExoCarta_1667
Vesiclepedia	VP_1667
Entrez Gene	1667
HGNC	2761
MIM	125220
UniProt	P59665
DEFA1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable
Saliva	19199708
Urine	15326289
Urine	22418980
Urine	22418980

Gene ontology annotations for DEFA1

Molecular Function     protein binding GO:0005515 IPI     pore-forming activity GO:0140911 IDA Biological Process     innate immune response in mucosa GO:0002227 IBA     innate immune response in mucosa GO:0002227 IDA     chemotaxis GO:0006935 TAS     immune response GO:0006955 TAS     T cell chemotaxis GO:0010818 IDA     antibacterial humoral response GO:0019731 IBA     antibacterial humoral response GO:0019731 IDA     estrogen receptor signaling pathway GO:0030520 IDA     killing of cells of another organism GO:0031640 IDA     defense response to protozoan GO:0042832 IMP     defense response to Gram-negative bacterium GO:0050829 IBA     defense response to Gram-positive bacterium GO:0050830 IBA     defense response to Gram-positive bacterium GO:0050830 IDA     defense response to fungus GO:0050832 IEA     defense response to virus GO:0051607 IEA     disruption of plasma membrane integrity in another organism GO:0051673 IBA     killing by host of symbiont cells GO:0051873 IDA     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IC     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IMP     cellular response to lipopolysaccharide GO:0071222 IBA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 HDA     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     Golgi lumen GO:0005796 TAS     azurophil granule lumen GO:0035578 TAS     collagen-containing extracellular matrix GO:0062023 HDA     collagen-containing extracellular matrix GO:0062023 HDA     extracellular exosome GO:0070062 HDA