Gene description for CACNA2D2
Gene name calcium channel, voltage-dependent, alpha 2/delta subunit 2
Gene symbol CACNA2D2
Other names/aliases CACNA2D
Species Homo sapiens
 Database cross references - CACNA2D2
ExoCarta ExoCarta_9254
Entrez Gene 9254
HGNC 1400
MIM 607082
UniProt Q9NY47  
 CACNA2D2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 25844599    
 Gene ontology annotations for CACNA2D2
Molecular Function
    calcium channel regulator activity GO:0005246 IBA
    voltage-gated calcium channel activity GO:0005245 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    neuromuscular junction development GO:0007528 IEA
    regulation of ion transmembrane transport GO:0034765 IEA
    regulation of multicellular organism growth GO:0040014 IEA
    small molecule metabolic process GO:0044281 TAS
    rhythmic synaptic transmission GO:0060024 IEA
    calcium ion transmembrane transport GO:0070588 IBA
    regulation of calcium ion transport GO:0051924 IBA
    regulation of insulin secretion GO:0050796 TAS
    positive regulation of organ growth GO:0046622 IEA
    muscle fiber development GO:0048747 IEA
    energy reserve metabolic process GO:0006112 TAS
Subcellular Localization
    voltage-gated calcium channel complex GO:0005891 IBA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified CACNA2D2 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CACNA2D2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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