Gene description for UPK2
Gene name uroplakin 2
Gene symbol UPK2
Other names/aliases UP2
UPII
Species Homo sapiens
 Database cross references - UPK2
ExoCarta ExoCarta_7379
Vesiclepedia VP_7379
Entrez Gene 7379
HGNC 12579
MIM 611558
UniProt O00526  
 UPK2 identified in exosomes derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for UPK2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    epithelial cell differentiation GO:0030855 IBA
    epithelial cell differentiation GO:0030855 IDA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified UPK2 in exosomes
1
Experiment ID 13
MISEV standards
IEM
Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
3
Experiment ID 196
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 197
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UPK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INTS4  
Affinity Capture-MS Homo sapiens
2 RHOF 54509
Affinity Capture-MS Homo sapiens
3 AMIGO1  
Two-hybrid Homo sapiens
4 CACNA2D2 9254
Affinity Capture-MS Homo sapiens
5 HPN  
Two-hybrid Homo sapiens
6 LPHN1  
Affinity Capture-MS Homo sapiens
7 ASGR2  
Two-hybrid Homo sapiens
8 BSCL2  
Two-hybrid Homo sapiens
9 SLC25A15  
Affinity Capture-MS Homo sapiens
10 ITIH2 3698
Affinity Capture-MS Homo sapiens
11 TMEM67 91147
Affinity Capture-MS Homo sapiens
12 BCAM 4059
Affinity Capture-MS Homo sapiens
13 GPR110  
Affinity Capture-MS Homo sapiens
14 SLC16A10 117247
Affinity Capture-MS Homo sapiens
15 FCGR2A 2212
Two-hybrid Homo sapiens
16 INTS8  
Affinity Capture-MS Homo sapiens
17 IL6ST 3572
Affinity Capture-MS Homo sapiens
18 ITFG1 81533
Affinity Capture-MS Homo sapiens
19 TMPRSS2 7113
Two-hybrid Homo sapiens
20 SLC20A1 6574
Affinity Capture-MS Homo sapiens
21 MON2 23041
Affinity Capture-MS Homo sapiens
22 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
23 ASIC1  
Affinity Capture-MS Homo sapiens
24 DGCR2 9993
Affinity Capture-MS Homo sapiens
25 TM9SF4 9777
Affinity Capture-MS Homo sapiens
26 MMP15 4324
Affinity Capture-MS Homo sapiens
27 ADGRG6 57211
Affinity Capture-MS Homo sapiens
28 TM9SF1 10548
Affinity Capture-MS Homo sapiens
29 SEMA4C 54910
Affinity Capture-MS Homo sapiens
30 ATP2A3 489
Affinity Capture-MS Homo sapiens
31 C3orf52  
Two-hybrid Homo sapiens
32 NLGN2 57555
Affinity Capture-MS Homo sapiens
33 ITFG3 83986
Affinity Capture-MS Homo sapiens
34 TNFSF9  
Affinity Capture-MS Homo sapiens
35 ALCAM 214
Affinity Capture-MS Homo sapiens
36 SMAGP  
Two-hybrid Homo sapiens
37 FCGR1A  
Two-hybrid Homo sapiens
38 KIR2DL3  
Two-hybrid Homo sapiens
39 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
40 SLC25A14  
Affinity Capture-MS Homo sapiens
41 ATP13A3 79572
Affinity Capture-MS Homo sapiens
42 CTAGE5 4253
Affinity Capture-MS Homo sapiens
43 TMEM87A 25963
Affinity Capture-MS Homo sapiens
44 FASTKD1  
Affinity Capture-MS Homo sapiens
45 ATP1A3 478
Affinity Capture-MS Homo sapiens
46 TMEM106C 79022
Two-hybrid Homo sapiens
47 KIR3DL3  
Two-hybrid Homo sapiens
48 TNFSF11  
Two-hybrid Homo sapiens
49 IPO11 51194
Affinity Capture-MS Homo sapiens
50 CLDN7 1366
Two-hybrid Homo sapiens
51 CNNM4 26504
Affinity Capture-MS Homo sapiens
52 ADPGK 83440
Affinity Capture-MS Homo sapiens
53 INTS5 80789
Affinity Capture-MS Homo sapiens
54 CLEC7A  
Two-hybrid Homo sapiens
55 ANTXR1 84168
Affinity Capture-MS Homo sapiens
56 GGT7 2686
Affinity Capture-MS Homo sapiens
57 TUBA1A 7846
Affinity Capture-MS Homo sapiens
58 RNF213 57674
Affinity Capture-MS Homo sapiens
59 COMTD1 118881
Affinity Capture-MS Homo sapiens
60 PCDHGA11  
Affinity Capture-MS Homo sapiens
61 ARL5B  
Affinity Capture-MS Homo sapiens
62 C1QL1  
Affinity Capture-MS Homo sapiens
63 KCNJ8  
Affinity Capture-MS Homo sapiens
64 BACE2 25825
Affinity Capture-MS Homo sapiens
65 INTS7  
Affinity Capture-MS Homo sapiens
66 ITM2C 81618
Two-hybrid Homo sapiens
67 LRRC8E 80131
Affinity Capture-MS Homo sapiens
68 XPOT 11260
Affinity Capture-MS Homo sapiens
69 TUBA1C 84790
Affinity Capture-MS Homo sapiens
70 UPK1A 11045
Affinity Capture-Western Homo sapiens
71 STOML3 161003
Two-hybrid Homo sapiens
72 KDELR2 11014
Affinity Capture-MS Homo sapiens
73 TUBB8 347688
Affinity Capture-MS Homo sapiens
74 GALNT14  
Affinity Capture-MS Homo sapiens
75 UPK2 7379
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
76 HEATR6  
Affinity Capture-MS Homo sapiens
77 CTNNA2 1496
Affinity Capture-MS Homo sapiens
78 ATP12A 479
Affinity Capture-MS Homo sapiens
79 DDR1 780
Affinity Capture-MS Homo sapiens
80 SV2A 9900
Affinity Capture-MS Homo sapiens
81 FNDC9  
Two-hybrid Homo sapiens
82 FANCD2  
Affinity Capture-MS Homo sapiens
83 TUBGCP5 114791
Affinity Capture-MS Homo sapiens
84 CLSTN3 9746
Affinity Capture-MS Homo sapiens
85 BTNL9  
Two-hybrid Homo sapiens
86 PCDH1 5097
Affinity Capture-MS Homo sapiens
87 RNF170 81790
Two-hybrid Homo sapiens
88 PON2 5445
Affinity Capture-MS Homo sapiens
89 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
90 MEX3A  
Affinity Capture-RNA Homo sapiens
91 ERGIC3 51614
Affinity Capture-MS Homo sapiens
92 GPR97  
Two-hybrid Homo sapiens
93 ATP6AP2 10159
Two-hybrid Homo sapiens
94 CCDC155  
Two-hybrid Homo sapiens
95 GBF1 8729
Affinity Capture-MS Homo sapiens
96 NRP2 8828
Affinity Capture-MS Homo sapiens
97 TM9SF3 56889
Affinity Capture-MS Homo sapiens
98 KIRREL 55243
Affinity Capture-MS Homo sapiens
99 SLC22A23  
Two-hybrid Homo sapiens
100 PCDH10 57575
Affinity Capture-MS Homo sapiens
101 HLA-F 3134
Affinity Capture-MS Homo sapiens
102 PRSS8 5652
Affinity Capture-MS Homo sapiens
103 LIME1 54923
Two-hybrid Homo sapiens
104 ABCA2 20
Affinity Capture-MS Homo sapiens
105 HEATR1 55127
Affinity Capture-MS Homo sapiens
106 PCDHB2  
Affinity Capture-MS Homo sapiens
107 TMEM59 9528
Affinity Capture-MS Homo sapiens
108 GPA33 10223
Two-hybrid Homo sapiens
109 GGCX 2677
Affinity Capture-MS Homo sapiens
110 PRKD2 25865
Affinity Capture-MS Homo sapiens
111 SEL1L3  
Affinity Capture-MS Homo sapiens
112 ABCB6 10058
Affinity Capture-MS Homo sapiens
113 PLP1 5354
Two-hybrid Homo sapiens
114 SLC1A1 6505
Affinity Capture-MS Homo sapiens
115 TTC27 55622
Affinity Capture-MS Homo sapiens
116 FCGRT 2217
Two-hybrid Homo sapiens
117 PCDH9  
Affinity Capture-MS Homo sapiens
118 TNFSF14  
Two-hybrid Homo sapiens
119 RPTOR 57521
Affinity Capture-MS Homo sapiens
120 LMAN2L 81562
Affinity Capture-MS Homo sapiens
121 INTS2  
Affinity Capture-MS Homo sapiens
122 FANCI 55215
Affinity Capture-MS Homo sapiens
123 LRP12 29967
Affinity Capture-MS Homo sapiens
124 EDEM3 80267
Affinity Capture-MS Homo sapiens
125 UBE3C 9690
Affinity Capture-MS Homo sapiens
126 FAM69A 388650
Affinity Capture-MS Homo sapiens
127 CELSR2  
Affinity Capture-MS Homo sapiens
128 ZNRF4  
Two-hybrid Homo sapiens
129 SORT1 6272
Affinity Capture-MS Homo sapiens
130 IPO13 9670
Affinity Capture-MS Homo sapiens
131 ADGRE5 976
Affinity Capture-MS Homo sapiens
132 LOC100507703  
Affinity Capture-MS Homo sapiens
133 ABHD17B 51104
Affinity Capture-MS Homo sapiens
134 CLEC17A  
Two-hybrid Homo sapiens
135 CNNM2 54805
Affinity Capture-MS Homo sapiens
136 C1QL4  
Affinity Capture-MS Homo sapiens
137 HLA-C 3107
Affinity Capture-MS Homo sapiens
138 KIAA0922  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which UPK2 is involved
No pathways found





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