Gene description for MMP15
Gene name matrix metallopeptidase 15 (membrane-inserted)
Gene symbol MMP15
Other names/aliases MT2-MMP
MTMMP2
SMCP-2
Species Homo sapiens
 Database cross references - MMP15
ExoCarta ExoCarta_4324
Entrez Gene 4324
HGNC 7161
MIM 602261
UniProt P51511  
 MMP15 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MMP15
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    enzyme activator activity GO:0008047 TAS
Biological Process
    collagen catabolic process GO:0030574 TAS
    response to estradiol GO:0032355 IEA
    extracellular matrix organization GO:0030198 TAS
    positive regulation of catalytic activity GO:0043085 TAS
    extracellular matrix disassembly GO:0022617 TAS
    endodermal cell differentiation GO:0035987 IEP
    proteolysis GO:0006508 IEA
    cellular protein modification process GO:0006464 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 IEA
    extracellular matrix GO:0031012 IEA
 Experiment description of studies that identified MMP15 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MMP15
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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