Gene description for ISG15
Gene name	ISG15 ubiquitin-like modifier
Gene symbol	ISG15
Other names/aliases	G1P2 IFI15 IMD38 IP17 UCRP hUCRP
Species	Homo sapiens
Database cross references - ISG15
ExoCarta	ExoCarta_9636
Entrez Gene	9636
HGNC	4053
MIM	147571
UniProt	P05161
ISG15 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Squamous carcinoma cells	20124223

Gene ontology annotations for ISG15

Molecular Function     protein tag GO:0031386 IEA     protein binding GO:0005515 IPI Biological Process     response to type I interferon GO:0034340 IDA     negative regulation of viral genome replication GO:0045071 IMP     negative regulation of protein ubiquitination GO:0031397 IDA     ISG15-protein conjugation GO:0032020 IMP     modification-dependent protein catabolic process GO:0019941 IEA     innate immune response GO:0045087 TAS     positive regulation of erythrocyte differentiation GO:0045648 IEA     type I interferon signaling pathway GO:0060337 TAS     DNA repair GO:0006281 TAS     cytokine-mediated signaling pathway GO:0019221 TAS     negative regulation of type I interferon production GO:0032480 TAS     viral process GO:0016032 IEA     translesion synthesis GO:0019985 TAS     regulation of interferon-gamma production GO:0032649 IMP     defense response to bacterium GO:0042742 IMP     defense response to virus GO:0051607 IMP Subcellular Localization     cytosol GO:0005829 TAS     extracellular region GO:0005576 IDA     nucleoplasm GO:0005654 TAS