ExoCarta: Gene summary

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Gene description for ISG15
Gene name	ISG15 ubiquitin-like modifier
Gene symbol	ISG15
Other names/aliases	G1P2 IFI15 IMD38 IP17 UCRP hUCRP
Species	Homo sapiens
Database cross references - ISG15
ExoCarta	ExoCarta_9636
Vesiclepedia	VP_9636
Entrez Gene	9636
HGNC	4053
MIM	147571
UniProt	P05161
ISG15 identified in sEVs derived from the following tissue/cell type
Chondrocytes	35931686
Chondrocytes	35931686
Endothelial cells	26027894
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Mesenchymal stem cells	36408942
Squamous carcinoma cells	20124223

Gene ontology annotations for ISG15

Molecular Function
	integrin binding	GO:0005178	IPI
	protein binding	GO:0005515	IPI
	protein tag activity	GO:0031386	IBA
	protein tag activity	GO:0031386	IDA
	ubiquitin protein ligase binding	GO:0031625	IBA
Biological Process
	integrin-mediated signaling pathway	GO:0007229	IDA
	response to virus	GO:0009615	IDA
	response to virus	GO:0009615	IEP
	protein ubiquitination	GO:0016567	IBA
	modification-dependent protein catabolic process	GO:0019941	IBA
	positive regulation of bone mineralization	GO:0030501	ISS
	negative regulation of protein ubiquitination	GO:0031397	IDA
	ISG15-protein conjugation	GO:0032020	IBA
	ISG15-protein conjugation	GO:0032020	IDA
	ISG15-protein conjugation	GO:0032020	IMP
	positive regulation of protein oligomerization	GO:0032461	IDA
	regulation of type II interferon production	GO:0032649	IMP
	positive regulation of interferon-beta production	GO:0032728	IDA
	positive regulation of type II interferon production	GO:0032729	IDA
	positive regulation of interleukin-10 production	GO:0032733	IDA
	response to type I interferon	GO:0034340	IDA
	defense response to bacterium	GO:0042742	IMP
	negative regulation of viral genome replication	GO:0045071	IDA
	negative regulation of viral genome replication	GO:0045071	IMP
	innate immune response	GO:0045087	IDA
	positive regulation of erythrocyte differentiation	GO:0045648	IEA
	defense response to virus	GO:0051607	IDA
	defense response to virus	GO:0051607	IMP
	negative regulation of type I interferon-mediated signaling pathway	GO:0060339	IMP
	protein localization to mitochondrion	GO:0070585	IDA
Subcellular Localization
	extracellular region	GO:0005576	IDA
	nucleus	GO:0005634	IBA
	nucleoplasm	GO:0005654	TAS
	cytoplasm	GO:0005737	IBA
	cytoplasm	GO:0005737	IC
	cytosol	GO:0005829	TAS

Experiment description of studies that identified ISG15 in sEVs

Experiment ID

497

MISEV standards
✘	Biophysical techniques
✔ CD9\|CD151\|CD63\|CD81\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|RAB5A\|SDCBP\|TFRC\|TSG101\|UCHL1	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

"Varela-EirÃn M, Carpintero-FernÃ¡ndez P, GuitiÃ¡n-CaamaÃ±o A, Varela-VÃ¡zquez A, GarcÃa-Yuste A, SÃ¡nchez-Temprano A, Bravo-LÃ³pez SB, YaÃ±ez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, MayÃ¡n MD."

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

T/C-28a2

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

498

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD151\|CD63\|CD81\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|RAB5A\|SDCBP\|TFRC\|TSG101\|UCHL1	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

T/C-28a2

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

226

MISEV standards
✔ EM	Biophysical techniques
✔ GAPDH\|CD9\|FLOT1	Enriched markers
✔ LMNA\|H2AFX\|ATP5A1\|TOMM20	Negative markers
✘	Particle analysis

Identified molecule

mRNA

Identification method

Small RNA sequencing (Illumina HiSeq 2000 (Solexa)

PubMed ID

26027894

Organism

Homo sapiens

Experiment description

"Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"

Authors

"Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"

Journal name

Journal of Extracellular Vesicles

Publication year

2015

Sample

Endothelial cells

Sample name

HMEC-1

Isolation/purification methods

Differential ultracentrifugation
Sucrose density gradient

Flotation density

1.10 g/mL

Molecules identified in the study

miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA

Methods used in the study

Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting

Experiment ID

363

MISEV standards
✘	Biophysical techniques
✔ TSG101\|GAPDH\|AQP1\|CD151\|CD81\|CD82\|CD9\|EPCAM\|FLOT1\|FLOT2\|ICAM1\|ITGA2B\|LAMP2\|RAB35\|RAB5A\|RAB5B\|SDCBP\|TFRC\|UCHL1	Enriched markers
✔ DCLK1	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33991177

Organism

Homo sapiens

Experiment description

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Authors

"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."

Journal name

Proteomics

Publication year

2021

Sample

Gastric cancer cells

Sample name

MKN1 - 100K pellet

Isolation/purification methods

Differential centrifugation
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

364

MISEV standards
✘	Biophysical techniques
✔ TSG101\|GAPDH\|AQP1\|CD151\|CD81\|CD82\|CD9\|EPCAM\|FLOT1\|FLOT2\|ICAM1\|ITGA2B\|LAMP2\|RAB35\|RAB5A\|RAB5B\|SDCBP\|TFRC\|UCHL1	Enriched markers
✔ DCLK1	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33991177

Organism

Homo sapiens

Experiment description

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Authors

"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."

Journal name

Proteomics

Publication year

2021

Sample

Gastric cancer cells

Sample name

MKN1 - 100K pellet

Isolation/purification methods

Differential centrifugation
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

365

MISEV standards
✘	Biophysical techniques
✔ TSG101\|GAPDH\|AQP1\|CD151\|CD81\|CD82\|CD9\|EPCAM\|FLOT1\|FLOT2\|ICAM1\|ITGA2B\|LAMP2\|RAB35\|RAB5A\|RAB5B\|SDCBP\|TFRC\|UCHL1	Enriched markers
✔ DCLK1	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33991177

Organism

Homo sapiens

Experiment description

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Authors

"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."

Journal name

Proteomics

Publication year

2021

Sample

Gastric cancer cells

Sample name

MKN1 - 100K pellet

Isolation/purification methods

Differential centrifugation
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

488

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD81\|CD63\|GAPDH\|SDCBP\|LAMP1\|TFRC\|UCHL1\|FLOT2\|LAMP2\|FLOT1\|ICAM1\|RAB5B\|CD151\|RAB35\|TSG101\|RAB5A\|CD82	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Homo sapiens

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Mesenchymal stem cells

Sample name

UCMSC

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

191

MISEV standards
✘	Biophysical techniques
✔ Alix\|CD81\|CD9	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

20124223

Organism

Homo sapiens

Experiment description

Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.

Authors

"Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."

Journal name

Mol Cell Proteomics

Publication year

2010

Sample

Squamous carcinoma cells

Sample name

Squamous carcinoma cell (A431)

Isolation/purification methods

Differential centrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for ISG15

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

SPATS2

Affinity Capture-MS

Homo sapiens

PPP1CB

5500

Affinity Capture-MS

Homo sapiens

NPLOC4

55666

Affinity Capture-MS

Homo sapiens

LDHB

3945

Affinity Capture-MS

Homo sapiens

PKM

5315

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TOP2B

7155

Affinity Capture-MS

Homo sapiens

TPM2

7169

Affinity Capture-MS

Homo sapiens

DDX17

10521

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ACTC1

Affinity Capture-MS

Homo sapiens

MAP4

4134

Affinity Capture-MS

Homo sapiens

CSNK2A1

1457

Affinity Capture-MS

Homo sapiens

KPNA2

3838

Affinity Capture-MS

Homo sapiens

CAPN7

23473

Affinity Capture-MS

Homo sapiens

FMR1-AS1

Affinity Capture-MS

Homo sapiens

PARK7

11315

Co-fractionation

Homo sapiens

SEPT2

4735

Affinity Capture-Western

Homo sapiens

PRKDC

5591

Affinity Capture-MS

Homo sapiens

DDX23

9416

Affinity Capture-MS

Homo sapiens

ALDH1A1

216

Affinity Capture-MS

Homo sapiens

DARS

1615

Affinity Capture-MS

Homo sapiens

AP2A1

160

Affinity Capture-MS

Homo sapiens

CALD1

800

Affinity Capture-MS

Homo sapiens

PSMB6

5694

Affinity Capture-MS

Homo sapiens

DNAJB1

3337

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FAF1

11124

Affinity Capture-MS

Homo sapiens

ERMP1

79956

Affinity Capture-MS

Homo sapiens

UCHL5

51377

Affinity Capture-MS

Homo sapiens

FUT4

Affinity Capture-MS

Homo sapiens

SFN

2810

Affinity Capture-Western

Homo sapiens

LMAN2

10960

Affinity Capture-MS

Homo sapiens

NSFL1C

55968

Affinity Capture-MS

Homo sapiens

TFRC

7037

Affinity Capture-MS

Homo sapiens

MSN

4478

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

SLC25A3

5250

Affinity Capture-MS

Homo sapiens

MYL6

4637

Affinity Capture-MS

Homo sapiens

RNF115

Affinity Capture-MS

Homo sapiens

EMC1

23065

Affinity Capture-MS

Homo sapiens

PPM1B

5495

Affinity Capture-MS

Homo sapiens

KRT19

3880

Affinity Capture-MS

Homo sapiens

TCP1

6950

Affinity Capture-MS

Homo sapiens

PSMA4

5685

Affinity Capture-MS

Homo sapiens

LUZP1

7798

Affinity Capture-MS

Homo sapiens

IFIT5

24138

Affinity Capture-MS

Homo sapiens

SRSF3

6428

Affinity Capture-MS

Homo sapiens

IFNA5

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TPM4

7171

Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

PABPC1

26986

Affinity Capture-MS

Homo sapiens

PSMD2

5708

Affinity Capture-MS

Homo sapiens

MYH9

4627

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ACTN4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CBX5

23468

Reconstituted Complex

Homo sapiens

KRT9

3857

Affinity Capture-MS

Homo sapiens

ENO1

2023

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

DNAJB2

3300

Affinity Capture-MS

Homo sapiens

TPM3

7170

Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

BRAP

Reconstituted Complex

Homo sapiens

DDX39B

7919

Affinity Capture-MS

Homo sapiens

FLOT2

2319

Affinity Capture-MS

Homo sapiens

PICALM

8301

Affinity Capture-MS

Homo sapiens

SRPK1

6732

Affinity Capture-MS

Homo sapiens

YOD1

Affinity Capture-MS

Homo sapiens

CACYBP

27101

Affinity Capture-MS

Homo sapiens

SQRDL

58472

Affinity Capture-MS

Homo sapiens

BCLAF1

9774

Affinity Capture-MS

Homo sapiens

CBX4

Affinity Capture-MS

Homo sapiens

TMPO

7112

Affinity Capture-MS

Homo sapiens

PSMB2

5690

Affinity Capture-MS

Homo sapiens

MRTO4

51154

Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

LRRC59

55379

Affinity Capture-MS

Homo sapiens

ZC3HAV1

56829

Affinity Capture-MS

Homo sapiens

LMO7

4008

Affinity Capture-MS

Homo sapiens

ANXA1

301

Affinity Capture-MS

Homo sapiens

BCAP31

10134

Affinity Capture-MS

Homo sapiens

ACTBL2

345651

Affinity Capture-MS

Homo sapiens

CSE1L

1434

Affinity Capture-MS

Homo sapiens

AAAS

8086

Affinity Capture-MS

Homo sapiens

EPRS

2058

Affinity Capture-MS

Homo sapiens

WIBG

84305

Affinity Capture-MS

Homo sapiens

RBBP4

5928

Affinity Capture-MS

Homo sapiens

MYO1C

4641

Affinity Capture-MS

Homo sapiens

BLK

640

Affinity Capture-MS

Homo sapiens

YTHDC1

Affinity Capture-MS

Homo sapiens

PLS1

5357

Affinity Capture-MS

Homo sapiens

KRT81

Affinity Capture-MS

Homo sapiens

IFNA7

Affinity Capture-MS

Homo sapiens

STAT1

6772

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

AP2A2

161

Affinity Capture-MS

Homo sapiens

RPL27A

6157

Affinity Capture-MS

Homo sapiens

HSPA4

3308

Affinity Capture-MS

Homo sapiens

SLC25A6

293

Affinity Capture-MS

Homo sapiens

DDX1

1653

Affinity Capture-MS

Homo sapiens

GCN1L1

10985

Affinity Capture-MS

Homo sapiens

SUPT16H

11198

Affinity Capture-MS

Homo sapiens

GNL3

26354

Affinity Capture-MS

Homo sapiens

NIT2

56954

Co-fractionation

Homo sapiens

PAFAH1B1

5048

Affinity Capture-MS

Homo sapiens

YBX1

4904

Affinity Capture-MS

Homo sapiens

RPS27A

6233

Affinity Capture-MS

Homo sapiens

FASN

2194

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

100

DAB2

1601

Affinity Capture-MS

Homo sapiens

101

PLEC

5339

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

102

RBM25

58517

Affinity Capture-MS

Homo sapiens

103

RUVBL2

10856

Affinity Capture-MS

Homo sapiens

104

MISP

126353

Affinity Capture-MS

Homo sapiens

105

CLPTM1

1209

Affinity Capture-MS

Homo sapiens

106

EPHX1

2052

Affinity Capture-MS

Homo sapiens

107

IST1

9798

Affinity Capture-MS

Homo sapiens

108

TKT

7086

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

109

HSP90AA1

3320

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

110

TARS

6897

Affinity Capture-MS

Homo sapiens

111

PSMA1

5682

Affinity Capture-MS

Homo sapiens

112

DYNC1H1

1778

Affinity Capture-MS

Homo sapiens

113

DDX3X

1654

Affinity Capture-MS

Homo sapiens

114

RUVBL1

8607

Affinity Capture-MS

Homo sapiens

115

GAPDH

2597

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

116

HNRNPL

3191

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

117

PSMA7

5688

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

118

RAB11A

8766

Affinity Capture-MS

Homo sapiens

119

PSMB7

5695

Affinity Capture-MS

Homo sapiens

120

RPL23A

6147

Affinity Capture-MS

Homo sapiens

121

ULK3

25989

Affinity Capture-MS

Homo sapiens

122

ADRM1

11047

Affinity Capture-MS

Homo sapiens

123

TAP1

6890

Affinity Capture-MS

Homo sapiens

124

ANXA2

302

Affinity Capture-MS

Homo sapiens

125

PSMC4

5704

Affinity Capture-MS

Homo sapiens

126

HSPA1B

3304

Affinity Capture-MS

Homo sapiens

127

IFIT2

3433

Affinity Capture-MS

Homo sapiens

128

HERC5

51191

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

129

PSMD3

5709

Affinity Capture-MS

Homo sapiens

130

GSTP1

2950

Affinity Capture-MS

Homo sapiens

131

LDHA

3939

Affinity Capture-MS

Homo sapiens

132

SPRTN

Affinity Capture-MS

Homo sapiens

133

CDK3

1018

Affinity Capture-MS

Homo sapiens

134

ATG5

9474

Proximity Label-MS

Homo sapiens

135

RBM15B

Affinity Capture-MS

Homo sapiens

136

DDX42

11325

Affinity Capture-MS

Homo sapiens

137

NACA

4666

Affinity Capture-MS

Homo sapiens

138

THRAP3

9967

Affinity Capture-MS

Homo sapiens

139

CHMP5

51510

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

140

HSP90AB1

3326

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

141

CAND1

55832

Affinity Capture-MS

Homo sapiens

142

COPA

1314

Affinity Capture-MS

Homo sapiens

143

DNAJB6

10049

Affinity Capture-MS

Homo sapiens

144

PGK1

5230

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

145

OGDH

4967

Affinity Capture-MS

Homo sapiens

146

MMP15

4324

Affinity Capture-MS

Homo sapiens

147

TOM1

10043

Affinity Capture-MS

Homo sapiens

148

HELZ2

Affinity Capture-MS

Homo sapiens

149

ACOT8

10005

Affinity Capture-MS

Homo sapiens

150

RPN2

6185

Reconstituted Complex

Homo sapiens

151

TUBB6

84617

Affinity Capture-MS

Homo sapiens

152

PALLD

23022

Affinity Capture-MS

Homo sapiens

153

IFNA4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

154

TIMM50

92609

Affinity Capture-MS

Homo sapiens

155

PLS3

5358

Affinity Capture-MS

Homo sapiens

156

PSMB3

5691

Affinity Capture-MS

Homo sapiens

157

UGP2

7360

Co-fractionation

Homo sapiens

158

ATXN2

6311

Affinity Capture-MS

Homo sapiens

159

CCT2

10576

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

160

PFN1

5216

Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

161

PRPF8

10594

Affinity Capture-MS

Homo sapiens

162

RBM28

55131

Affinity Capture-MS

Homo sapiens

163

RAI14

26064

Affinity Capture-MS

Homo sapiens

164

PSMD13

5719

Affinity Capture-MS

Homo sapiens

165

UBAP2L

9898

Affinity Capture-MS

Homo sapiens

166

PSMD14

10213

Affinity Capture-MS

Homo sapiens

167

NFIX

4784

Affinity Capture-MS

Homo sapiens

168

RNF213

57674

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

169

SNRNP200

23020

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

170

TMEM43

79188

Affinity Capture-MS

Homo sapiens

171

IFNA2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

172

CCNL1

Affinity Capture-MS

Homo sapiens

173

NCL

4691

Reconstituted Complex

Homo sapiens

174

UBTF

7343

Affinity Capture-MS

Homo sapiens

175

LYAR

55646

Affinity Capture-MS

Homo sapiens

176

PSMA5

5686

Affinity Capture-MS

Homo sapiens

177

IARS

3376

Affinity Capture-MS

Homo sapiens

178

UBXN6

80700

Affinity Capture-MS

Homo sapiens

179

RSL1D1

26156

Affinity Capture-MS

Homo sapiens

180

MYH7B

Affinity Capture-MS

Homo sapiens

181

UFD1L

7353

Affinity Capture-MS

Homo sapiens

182

PSMA3

5684

Affinity Capture-MS

Homo sapiens

183

ACLY

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

184

CANX

821

Affinity Capture-MS

Homo sapiens

185

ATL3

25923

Affinity Capture-MS

Homo sapiens

186

UBE2L6

9246

Affinity Capture-MS

Homo sapiens

187

WDR33

55339

Affinity Capture-MS

Homo sapiens

188

TJP1

7082

Affinity Capture-MS

Homo sapiens

189

MX1

4599

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

190

NUP43

348995

Affinity Capture-MS

Homo sapiens

191

FUS

2521

Reconstituted Complex

Homo sapiens

192

LARS

51520

Affinity Capture-MS

Homo sapiens

193

EFTUD2

9343

Affinity Capture-MS

Homo sapiens

194

TPM1

7168

Affinity Capture-MS

Homo sapiens

195

IFIT1

3434

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

196

BAG1

573

Affinity Capture-MS

Homo sapiens

197

JAK1

3716

Affinity Capture-MS

Homo sapiens

198

SLC3A2

6520

Affinity Capture-MS

Homo sapiens

199

TMOD3

29766

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

200

EEF1A2

1917

Affinity Capture-MS

Homo sapiens

201

DSTN

11034

Affinity Capture-Western

Homo sapiens

202

DDB1

1642

Affinity Capture-MS

Homo sapiens

203

AHNAK2

113146

Affinity Capture-MS

Homo sapiens

204

PCM1

5108

Affinity Capture-MS

Homo sapiens

205

TKFC

26007

Co-fractionation

Homo sapiens

206

MPRIP

23164

Affinity Capture-MS

Homo sapiens

207

LMNA

4000

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

208

IFNA21

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

209

FTSJ3

117246

Affinity Capture-MS

Homo sapiens

210

PHGDH

26227

Affinity Capture-MS

Homo sapiens

211

AIMP1

9255

Affinity Capture-MS

Homo sapiens

212

GSR

2936

Affinity Capture-MS

Homo sapiens

213

CD99L2

83692

Affinity Capture-MS

Homo sapiens

214

RAD23A

5886

Affinity Capture-MS

Homo sapiens

215

TRAF2

7186

Affinity Capture-MS

Homo sapiens

216

PARP1

142

Affinity Capture-MS

Homo sapiens

217

ILF3

3609

Affinity Capture-MS

Homo sapiens

218

FOLR1

2348

Affinity Capture-MS

Homo sapiens

219

SSRP1

6749

Affinity Capture-MS

Homo sapiens

220

HDAC6

10013

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens

221

UBA7

7318

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens

222

KLHL26

Reconstituted Complex

Homo sapiens

223

EZR

7430

Affinity Capture-MS

Homo sapiens

224

PTBP1

5725

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

225

SQSTM1

8878

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

226

SMAD4

Affinity Capture-MS

Homo sapiens

227

ZNF281

Affinity Capture-MS

Homo sapiens

228

HNRNPK

3190

Affinity Capture-MS

Homo sapiens

229

YTHDF3

Affinity Capture-MS

Homo sapiens

230

RPS26

6231

Affinity Capture-MS

Homo sapiens

231

DDX39A

10212

Affinity Capture-MS

Homo sapiens

232

BAG5

9529

Affinity Capture-MS

Homo sapiens

233

SUMO1

7341

Reconstituted Complex

Homo sapiens

234

DNAJB4

11080

Affinity Capture-MS

Homo sapiens

235

ATP1A1

476

Affinity Capture-MS

Homo sapiens

236

PRDX1

5052

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

237

HERC3

8916

Affinity Capture-MS

Homo sapiens

238

C1QBP

708

Affinity Capture-MS

Homo sapiens

239

PSMD1

5707

Affinity Capture-MS

Homo sapiens

240

CKAP4

10970

Affinity Capture-MS

Homo sapiens

241

IFNW1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

242

ATP13A1

57130

Affinity Capture-MS

Homo sapiens

243

AKR1B10

57016

Affinity Capture-MS

Homo sapiens

244

HACD3

51495

Affinity Capture-MS

Homo sapiens

245

PSMA6

5687

Affinity Capture-MS

Homo sapiens

246

PSMD4

5710

Affinity Capture-MS

Homo sapiens

247

EEF1G

1937

Affinity Capture-MS

Homo sapiens

248

GULP1

51454

Affinity Capture-MS

Homo sapiens

249

ERCC2

2068

Affinity Capture-MS

Homo sapiens

250

TM9SF2

9375

Affinity Capture-MS

Homo sapiens

251

LAP3

51056

Affinity Capture-MS

Homo sapiens

252

LIMCH1

22998

Affinity Capture-MS

Homo sapiens

253

MYO5C

55930

Affinity Capture-MS

Homo sapiens

254

FUBP3

8939

Affinity Capture-MS

Homo sapiens

255

PEBP1

5037

Affinity Capture-MS

Homo sapiens

256

PPP1R10

Affinity Capture-MS

Homo sapiens

257

TRAFD1

Affinity Capture-MS

Homo sapiens

258

POR

5447

Affinity Capture-MS

Homo sapiens

259

MEPCE

56257

Affinity Capture-MS

Homo sapiens

260

PLOD3

8985

Affinity Capture-MS

Homo sapiens

261

FAM98A

25940

Affinity Capture-MS

Homo sapiens

262

SENP1

Affinity Capture-MS

Homo sapiens

263

COPB2

9276

Affinity Capture-MS

Homo sapiens

264

IQGAP1

8826

Affinity Capture-MS

Homo sapiens

265

HERC4

26091

Affinity Capture-MS

Homo sapiens

266

SF3A2

8175

Affinity Capture-MS

Homo sapiens

267

UGDH

7358

Affinity Capture-MS

Homo sapiens

268

PGD

5226

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

269

YWHAB

7529

Affinity Capture-MS

Homo sapiens

270

DEPDC7

Affinity Capture-MS

Homo sapiens

271

MTDH

92140

Affinity Capture-MS

Homo sapiens

272

IFNA14

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

273

HSPA8

3312

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

274

CHD1

1105

Affinity Capture-MS

Homo sapiens

275

BRIX1

55299

Affinity Capture-MS

Homo sapiens

276

EIF2AK2

5610

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

277

ALDH1A3

220

Co-fractionation

Homo sapiens

278

RAD23B

5887

Affinity Capture-MS

Homo sapiens

279

MYO18A

399687

Affinity Capture-MS

Homo sapiens

280

ATP5A1

498

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

281

PSMB4

5692

Affinity Capture-MS

Homo sapiens

282

GTF2IRD1

Affinity Capture-MS

Homo sapiens

283

AKR1C3

8644

Affinity Capture-MS

Homo sapiens

284

MARS

4141

Affinity Capture-MS

Homo sapiens

285

PSMD11

5717

Affinity Capture-MS

Homo sapiens

286

PSMB1

5689

Affinity Capture-MS

Homo sapiens

287

ABCF2

10061

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

288

RGS3

5998

Affinity Capture-MS

Homo sapiens

289

TUBA1B

10376

Reconstituted Complex

Homo sapiens

290

RAN

5901

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

291

CIRH1A

84916

Affinity Capture-MS

Homo sapiens

292

U2AF2

11338

Affinity Capture-MS

Homo sapiens

293

RDH11

51109

Affinity Capture-MS

Homo sapiens

294

FLNB

2317

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

295

ACTB

Affinity Capture-MS

Homo sapiens

296

UBE2D3

7323

Affinity Capture-Western

Homo sapiens

297

MLF2

8079

Affinity Capture-MS

Homo sapiens

298

HNRNPA3

220988

Affinity Capture-MS

Homo sapiens

299

MYBBP1A

10514

Affinity Capture-MS

Homo sapiens

300

ACTG1

Affinity Capture-MS

Homo sapiens

301

SPATS2L

26010

Affinity Capture-MS

Homo sapiens

302

BAG2

9532

Affinity Capture-MS

Homo sapiens

303

AHNAK

79026

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

304

TAB2

Affinity Capture-MS

Homo sapiens

305

EPPK1

83481

Affinity Capture-MS

Homo sapiens

306

DDB2

Affinity Capture-MS

Homo sapiens

307

PSMA2

5683

Affinity Capture-MS

Homo sapiens

308

MYO5A

4644

Affinity Capture-MS

Homo sapiens

309

DHX30

22907

Affinity Capture-MS

Homo sapiens

310

MAP3K7

Affinity Capture-MS

Homo sapiens

311

SERPINB5

5268

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

312

AP2M1

1173

Affinity Capture-MS

Homo sapiens

313

TM9SF3

56889

Affinity Capture-MS

Homo sapiens

314

AKR1C2

Affinity Capture-MS

Homo sapiens

315

IFNA1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

316

SEC16A

9919

Affinity Capture-MS

Homo sapiens

317

TP63

Affinity Capture-MS

Homo sapiens

318

HP1BP3

50809

Affinity Capture-MS

Homo sapiens

319

SPAST

6683

Affinity Capture-MS

Homo sapiens

320

MATR3

9782

Affinity Capture-MS

Homo sapiens

321

FLII

2314

Affinity Capture-MS

Homo sapiens

322

GALNT2

2590

Affinity Capture-MS

Homo sapiens

323

HSPD1

3329

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

324

FLOT1

10211

Affinity Capture-MS

Homo sapiens

325

XRCC5

7520

Affinity Capture-MS

Homo sapiens

326

ATIC

471

Affinity Capture-MS

Homo sapiens

327

DHX9

1660

Affinity Capture-MS

Homo sapiens

328

IMMT

10989

Affinity Capture-MS

Homo sapiens

329

PHB2

11331

Affinity Capture-MS

Homo sapiens

330

CLK1

Affinity Capture-MS

Homo sapiens

331

CCT8

10694

Affinity Capture-MS

Homo sapiens

332

NUP205

23165

Affinity Capture-MS

Homo sapiens

333

GBP1

2633

Affinity Capture-MS

Homo sapiens

334

SIN3A

Affinity Capture-MS

Homo sapiens

335

GPI

2821

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

336

ERLIN1

10613

Affinity Capture-MS

Homo sapiens

337

STK38

11329

Affinity Capture-MS

Homo sapiens

338

IFNA8

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

339

PRRC2C

23215

Affinity Capture-MS

Homo sapiens

340

HNRNPM

4670

Affinity Capture-MS

Homo sapiens

341

TUBB3

10381

Affinity Capture-MS

Homo sapiens

342

G3BP1

10146

Affinity Capture-MS

Homo sapiens

343

HSPB1

3315

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

344

GRPEL1

80273

Reconstituted Complex

Homo sapiens

345

PLOD1

5351

Affinity Capture-MS

Homo sapiens

346

SND1

27044

Affinity Capture-MS

Homo sapiens

347

MTHFD1

4522

Affinity Capture-MS

Homo sapiens

348

DDX58

23586

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

349

MYL12A

10627

Affinity Capture-MS

Homo sapiens

350

TRIM25

7706

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

351

FAM120C

54954

Affinity Capture-MS

Homo sapiens

352

TRAP1

10131

Affinity Capture-MS

Homo sapiens

353

ACTA1

Affinity Capture-MS

Homo sapiens

354

SF3B4

10262

Affinity Capture-MS

Homo sapiens

355

PRDX6

9588

Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

356

FLNA

2316

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

357

MYO1E

4643

Affinity Capture-MS

Homo sapiens

358

HNRNPF

3185

Affinity Capture-MS

Homo sapiens

359

SERBP1

26135

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

360

VIM

7431

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

361

ZNF318

24149

Co-fractionation

Homo sapiens

362

CAV1

857

Affinity Capture-MS

Homo sapiens

363

CDKN2A

1029

Affinity Capture-MS

Homo sapiens

364

DPY19L1

23333

Affinity Capture-MS

Homo sapiens

365

AP2B1

163

Affinity Capture-MS

Homo sapiens

366

CCT3

7203

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

367

QARS

5859

Affinity Capture-MS

Homo sapiens

368

ARID5B

84159

Affinity Capture-MS

Homo sapiens

369

MITD1

129531

Affinity Capture-MS

Homo sapiens

370

PSMD6

9861

Affinity Capture-MS

Homo sapiens

371

VAPA

9218

Affinity Capture-MS

Homo sapiens

372

ANXA3

306

Affinity Capture-MS

Homo sapiens

373

RPL13A

23521

Affinity Capture-MS

Homo sapiens

374

TAB1

10454

Affinity Capture-MS

Homo sapiens

375

CCT4

10575

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

376

PPIA

5478

Affinity Capture-MS

Homo sapiens

377

CFL1

1072

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

378

TOP2A

7153

Affinity Capture-MS

Homo sapiens

379

PPP1R12A

4659

Affinity Capture-MS

Homo sapiens

380

DYRK1A

1859

Affinity Capture-MS

Homo sapiens

381

SPECC1L

23384

Affinity Capture-MS

Homo sapiens

382

ATXN2L

11273

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

383

USP18

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

384

RPL24

6152

Affinity Capture-MS

Homo sapiens

385

UEVLD

55293

Affinity Capture-MS

Homo sapiens

386

PSMC6

5706

Affinity Capture-MS

Homo sapiens

387

IFIT3

3437

Affinity Capture-MS

Homo sapiens

388

DDOST

1650

Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

389

PGRMC2

10424

Affinity Capture-MS

Homo sapiens

390

SERPINH1

871

Affinity Capture-MS

Homo sapiens

391

MYO1B

4430

Affinity Capture-MS

Homo sapiens

392

NEDD4

4734

Affinity Capture-Western

Homo sapiens

393

PSMC3

5702

Affinity Capture-MS

Homo sapiens

394

WDR1

9948

Affinity Capture-MS

Homo sapiens

395

FARS2

10667

Affinity Capture-MS

Homo sapiens

396

IFNA10

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

397

HSPA1A

3303

Affinity Capture-MS

Homo sapiens

398

USP21

Biochemical Activity

Homo sapiens

399

TBL2

26608

Affinity Capture-MS

Homo sapiens

400

PSMC1

5700

Affinity Capture-MS

Homo sapiens

401

STAU1

6780

Affinity Capture-MS

Homo sapiens

402

LRRFIP2

9209

Affinity Capture-MS

Homo sapiens

403

VCP

7415

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

404

EEF2

1938

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

405

ZMPSTE24

10269

Affinity Capture-MS

Homo sapiens

406

BMP2K

55589

Affinity Capture-MS

Homo sapiens

407

DDX54

79039

Affinity Capture-MS

Homo sapiens

408

GANAB

23193

Affinity Capture-MS

Homo sapiens

409

MYH10

4628

Affinity Capture-MS

Homo sapiens

410

DNAJB5

Affinity Capture-MS

Homo sapiens

411

ZC3H15

55854

Affinity Capture-MS

Homo sapiens

412

ATP5B

506

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

413

ALDH4A1

8659

Co-fractionation

Homo sapiens

414

BAG3

9531

Affinity Capture-MS		Homo sapiens
Affinity Capture-Luminescence		Homo sapiens

415

ACTN1

Affinity Capture-MS

Homo sapiens

416

UBE2N

7334

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

417

ASCC3

10973

Affinity Capture-MS

Homo sapiens

418

CLINT1

9685

Affinity Capture-MS

Homo sapiens

419

EIF4G1

1981

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

420

ATP2B1

490

Affinity Capture-MS

Homo sapiens

421

CCT6A

908

Affinity Capture-MS

Homo sapiens

422

NAT10

55226

Affinity Capture-MS

Homo sapiens

423

CTNNB1

1499

Affinity Capture-Western

Homo sapiens

424

SRSF1

6426

Affinity Capture-MS

Homo sapiens

425

ANXA5

308

Affinity Capture-MS

Homo sapiens

426

IFNL3

Affinity Capture-MS

Homo sapiens

427

TXNRD1

7296

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

428

RPL3

6122

Reconstituted Complex

Homo sapiens

429

NAP1L1

4673

Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

430

UACA

55075

Affinity Capture-MS

Homo sapiens

431

PSMD7

5713

Affinity Capture-MS

Homo sapiens

432

TAGLN

6876

Affinity Capture-MS

Homo sapiens

433

GDI2

2665

Affinity Capture-MS

Homo sapiens

434

MLF1

Affinity Capture-MS

Homo sapiens

435

MYL6B

140465

Affinity Capture-MS

Homo sapiens

436

MYO6

4646

Affinity Capture-MS

Homo sapiens

437

XRCC6

2547

Affinity Capture-MS

Homo sapiens

438

MYOF

26509

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

439

TXNL1

9352

Affinity Capture-MS

Homo sapiens

440

PSMB5

5693

Affinity Capture-MS

Homo sapiens

441

LGMN

5641

Affinity Capture-MS

Homo sapiens

442

SF3B3

23450

Affinity Capture-MS

Homo sapiens

443

CLTC

1213

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

444

FAM188A

80013

Affinity Capture-MS

Homo sapiens

445

HNRNPU

3192

Affinity Capture-MS

Homo sapiens

446

UBXN1

51035

Affinity Capture-MS

Homo sapiens

447

MGEA5

10724

Affinity Capture-MS

Homo sapiens

448

GSN

2934

Affinity Capture-MS

Homo sapiens

449

DHX15

1665

Affinity Capture-MS

Homo sapiens

450

TNK2

10188

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

451

SPTAN1

6709

Affinity Capture-MS

Homo sapiens

452

CLIC1

1192

Affinity Capture-MS

Homo sapiens

453

HNRNPA2B1

3181

Affinity Capture-MS

Homo sapiens

454

LMAN1

3998

Affinity Capture-MS

Homo sapiens

455

PSMD8

5714

Affinity Capture-MS

Homo sapiens

456

ELAVL1

1994

Affinity Capture-MS

Homo sapiens

457

TAF2

Affinity Capture-MS

Homo sapiens

458

ATP2A2

488

Affinity Capture-MS

Homo sapiens

459

ARF4

378

Affinity Capture-MS

Homo sapiens

460

ELF3

1999

Affinity Capture-MS

Homo sapiens

461

TAPBP

6892

Affinity Capture-MS

Homo sapiens

462

PCBP1

5093

Affinity Capture-MS

Homo sapiens

463

CAD

790

Affinity Capture-MS

Homo sapiens

464

IBTK

25998

Affinity Capture-MS

Homo sapiens

465

RPL23

9349

Reconstituted Complex

Homo sapiens

466

CYB5R3

1727

Co-fractionation

Homo sapiens

467

MYL12B

103910

Affinity Capture-MS

Homo sapiens

468

RARS

5917

Affinity Capture-MS

Homo sapiens

469

GNB2L1

10399

Affinity Capture-MS

Homo sapiens

470

CUEDC1

404093

Affinity Capture-MS

Homo sapiens

471

WARS

7453

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

472

ALDOA

226

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

473

DSG2

1829

Affinity Capture-MS

Homo sapiens

474

QTRTD1

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which ISG15 is involved

Pathway	Evidence	Source
Antiviral mechanism by IFN-stimulated genes	TAS	Reactome
Cytokine Signaling in Immune system	TAS	Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS	Reactome
Disease	TAS	Reactome
DNA Damage Bypass	TAS	Reactome
DNA Repair	TAS	Reactome
Immune System	TAS	Reactome
Infectious disease	TAS	Reactome
Influenza Infection	TAS	Reactome
Innate Immune System	TAS	Reactome
Interferon alpha/beta signaling	TAS	Reactome
Interferon Signaling	TAS	Reactome
ISG15 antiviral mechanism	TAS	Reactome
Negative regulators of DDX58/IFIH1 signaling	TAS	Reactome
NS1 Mediated Effects on Host Pathways	TAS	Reactome
PKR-mediated signaling	TAS	Reactome
Respiratory Syncytial Virus Infection Pathway	TAS	Reactome
RSV-host interactions	TAS	Reactome
SARS-CoV Infections	TAS	Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses	TAS	Reactome
SARS-CoV-2 Infection	TAS	Reactome
SARS-CoV-2-host interactions	TAS	Reactome
Termination of translesion DNA synthesis	TAS	Reactome
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	TAS	Reactome
Viral Infection Pathways	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here