Gene description for WIBG
Gene name within bgcn homolog (Drosophila)
Gene symbol WIBG
Other names/aliases PYM
Species Homo sapiens
 Database cross references - WIBG
ExoCarta ExoCarta_84305
Vesiclepedia VP_84305
Entrez Gene 84305
HGNC 30258
UniProt Q9BRP8  
 WIBG identified in exosomes derived from the following tissue/cell type
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for WIBG
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    protein binding GO:0005515 IPI
    ribosome binding GO:0043022 IDA
Biological Process
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 IDA
    positive regulation of translation GO:0045727 IDA
    exon-exon junction complex disassembly GO:1903259 IBA
    exon-exon junction complex disassembly GO:1903259 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cell junction GO:0030054 IDA
    exon-exon junction complex GO:0035145 IBA
    exon-exon junction complex GO:0035145 IDA
 Experiment description of studies that identified WIBG in exosomes
1
Experiment ID 426
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 427
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 419
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 419
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 420
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 420
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 434
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 435
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for WIBG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 ISG15 9636
Affinity Capture-MS Homo sapiens
3 DNAJC8 22826
Affinity Capture-MS Homo sapiens
4 POT1  
Two-hybrid Homo sapiens
5 EIF2S3 1968
Co-fractionation Homo sapiens
6 DNTTIP1 116092
Co-fractionation Homo sapiens
7 TARDBP 23435
Affinity Capture-MS Homo sapiens
8 RPS19 6223
Co-fractionation Homo sapiens
9 BYSL 705
Co-fractionation Homo sapiens
10 MAD2L1BP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 Csk 12988
Affinity Capture-MS Mus musculus
12 SOX2  
Affinity Capture-MS Homo sapiens
13 APP 351
Reconstituted Complex Homo sapiens
14 FAU 2197
Co-fractionation Homo sapiens
15 RPS3 6188
Co-fractionation Homo sapiens
16 RPS18 6222
Co-fractionation Homo sapiens
17 RPS6 6194
Co-fractionation Homo sapiens
18 RPS20 6224
Co-fractionation Homo sapiens
19 RNPS1 10921
Co-fractionation Homo sapiens
20 GTF2E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ANKRD49  
Affinity Capture-MS Homo sapiens
22 MAGOHB 55110
Affinity Capture-MS Homo sapiens
23 SRRM2 23524
Co-fractionation Homo sapiens
24 RPS8 6202
Co-fractionation Homo sapiens
25 RPS9 6203
Co-fractionation Homo sapiens
26 UBQLN1 29979
Co-fractionation Homo sapiens
27 MOB1B 92597
Affinity Capture-MS Homo sapiens
28 KLHL20  
Affinity Capture-MS Homo sapiens
29 MYCN  
Affinity Capture-MS Homo sapiens
30 MAD2L1 4085
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 RBM8A 9939
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 RPS26 6231
Co-fractionation Homo sapiens
33 PRNP 5621
Reconstituted Complex Homo sapiens
34 E2F4  
Affinity Capture-MS Homo sapiens
35 RPS23 6228
Co-fractionation Homo sapiens
36 TNKS 8658
Affinity Capture-MS Homo sapiens
37 TRIM26 7726
Affinity Capture-MS Homo sapiens
38 RPS10 6204
Co-fractionation Homo sapiens
39 MSX2  
Affinity Capture-MS Homo sapiens
40 DNAJB7  
Affinity Capture-MS Homo sapiens
41 PNO1 56902
Co-fractionation Homo sapiens
42 VRK1 7443
Co-fractionation Homo sapiens
43 DEK 7913
Co-fractionation Homo sapiens
44 NELFE 7936
Co-fractionation Homo sapiens
45 NEDD4L 23327
Biochemical Activity Homo sapiens
46 KCNA6  
Affinity Capture-MS Homo sapiens
47 SLC25A32 81034
Affinity Capture-MS Homo sapiens
48 Rrbp1  
Affinity Capture-MS Mus musculus
49 MAGOH 4116
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TPM3 7170
Cross-Linking-MS (XL-MS) Homo sapiens
51 DDX39B 7919
Co-fractionation Homo sapiens
52 RPS15A 6210
Co-fractionation Homo sapiens
53 SRPK1 6732
Affinity Capture-MS Homo sapiens
54 GSX1  
Affinity Capture-MS Homo sapiens
55 RABGGTA 5875
Affinity Capture-MS Homo sapiens
56 MRRF  
Proximity Label-MS Homo sapiens
57 RPS2 6187
Co-fractionation Homo sapiens
58 LRRC59 55379
Proximity Label-MS Homo sapiens
59 RC3H2  
Affinity Capture-MS Homo sapiens
60 DNAJC2 27000
Proximity Label-MS Homo sapiens
61 RTN4IP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
62 KCMF1 56888
Co-fractionation Homo sapiens
63 ATP5F1 515
Affinity Capture-MS Homo sapiens
64 SERPINB5 5268
Affinity Capture-MS Homo sapiens
65 NXF1 10482
Affinity Capture-RNA Homo sapiens
66 XPO1 7514
Affinity Capture-MS Homo sapiens
67 KIF1BP 26128
Affinity Capture-MS Homo sapiens
68 MYC  
Affinity Capture-MS Homo sapiens
69 RPS13 6207
Co-fractionation Homo sapiens
70 EMC2 9694
Affinity Capture-MS Homo sapiens
71 RPS14 6208
Co-fractionation Homo sapiens
72 RPL35A 6165
Affinity Capture-MS Homo sapiens
73 RPS25 6230
Co-fractionation Homo sapiens
74 UPF3B 65109
Co-fractionation Homo sapiens
75 NEDD4 4734
Reconstituted Complex Homo sapiens
76 Mad2l1 56150
Affinity Capture-MS Mus musculus
77 TSR1 55720
Co-fractionation Homo sapiens
78 AKAP1 8165
Affinity Capture-MS Homo sapiens
79 CDKN2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 RPS16 6217
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
81 TOE1 114034
Co-fractionation Homo sapiens
82 ACIN1 22985
Co-fractionation Homo sapiens
83 FBXL6  
Affinity Capture-MS Homo sapiens
84 CDA 978
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 Rbm8a  
Affinity Capture-MS Mus musculus
86 RPS12 6206
Co-fractionation Homo sapiens
87 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 RPS4X 6191
Co-fractionation Homo sapiens
89 RPS27 6232
Co-fractionation Homo sapiens
90 NELFA  
Affinity Capture-MS Homo sapiens
91 EIF4A3 9775
Co-fractionation Homo sapiens
92 RPS5 6193
Co-fractionation Homo sapiens
93 ESR1  
Affinity Capture-MS Homo sapiens
94 RPS28 6234
Co-fractionation Homo sapiens
95 RPS3A 6189
Co-fractionation Homo sapiens
96 RPS24 6229
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
97 MOV10 4343
Affinity Capture-RNA Homo sapiens
98 MND1  
Affinity Capture-MS Homo sapiens
99 RPS7 6201
Co-fractionation Homo sapiens
100 ZNF503 84858
Co-fractionation Homo sapiens
101 RPS27L 51065
Co-fractionation Homo sapiens
102 RPS29 6235
Co-fractionation Homo sapiens
103 RC3H1 149041
Affinity Capture-MS Homo sapiens
104 MAST3  
Affinity Capture-MS Homo sapiens
105 DCAF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 EP300 2033
Affinity Capture-MS Homo sapiens
107 CASC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 Magoh  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which WIBG is involved
No pathways found





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