Gene description for RABGGTA
Gene name Rab geranylgeranyltransferase, alpha subunit
Gene symbol RABGGTA
Other names/aliases PTAR3
Species Homo sapiens
 Database cross references - RABGGTA
ExoCarta ExoCarta_5875
Entrez Gene 5875
HGNC 9795
MIM 601905
UniProt Q92696  
 RABGGTA identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RABGGTA
Molecular Function
    Rab GTPase binding GO:0017137 ISS
    zinc ion binding GO:0008270 IEA
    Rab geranylgeranyltransferase activity GO:0004663 ISS
Biological Process
    cellular protein modification process GO:0006464 TAS
    visual perception GO:0007601 TAS
    protein geranylgeranylation GO:0018344 ISS
Subcellular Localization
    Rab-protein geranylgeranyltransferase complex GO:0005968 ISS
 Experiment description of studies that identified RABGGTA in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RABGGTA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RABGGTA is involved
No pathways found





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