Gene description for IRF6
Gene name interferon regulatory factor 6
Gene symbol IRF6
Other names/aliases LPS
OFC6
PIT
PPS
PPS1
VWS
VWS1
Species Homo sapiens
 Database cross references - IRF6
ExoCarta ExoCarta_3664
Entrez Gene 3664
HGNC 6121
MIM 607199
UniProt O14896  
 IRF6 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for IRF6
Molecular Function
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 ISS
    regulatory region DNA binding GO:0000975 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 ISS
Biological Process
    keratinocyte proliferation GO:0043616 IEA
    transcription, DNA-templated GO:0006351 IEA
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    mammary gland epithelial cell differentiation GO:0060644 ISS
    cell development GO:0048468 IEA
    negative regulation of cell proliferation GO:0008285 IDA
    cell cycle arrest GO:0007050 IDA
    type I interferon signaling pathway GO:0060337 TAS
    keratinocyte differentiation GO:0030216 IEA
    cytokine-mediated signaling pathway GO:0019221 TAS
    positive regulation of transcription, DNA-templated GO:0045893 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified IRF6 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for IRF6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LBP 3929
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which IRF6 is involved
PathwayEvidenceSource
Interferon alpha/beta signaling TAS Reactome
Interferon gamma signaling TAS Reactome





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