Gene description for IRF6
Gene name	interferon regulatory factor 6
Gene symbol	IRF6
Other names/aliases	LPS OFC6 PIT PPS PPS1 VWS VWS1
Species	Homo sapiens
Database cross references - IRF6
ExoCarta	ExoCarta_3664
Vesiclepedia	VP_3664
Entrez Gene	3664
HGNC	6121
MIM	607199
UniProt	O14896
IRF6 identified in sEVs derived from the following tissue/cell type
Urine	19056867

Gene ontology annotations for IRF6

Molecular Function     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA     DNA binding GO:0003677 ISS     DNA-binding transcription factor activity GO:0003700 ISS     protein binding GO:0005515 IPI     sequence-specific DNA binding GO:0043565 IDA     sequence-specific double-stranded DNA binding GO:1990837 IDA Biological Process     immune system process GO:0002376 IBA     regulation of transcription by RNA polymerase II GO:0006357 IBA     negative regulation of cell population proliferation GO:0008285 IDA     negative regulation of keratinocyte proliferation GO:0010839 IEA     keratinocyte differentiation GO:0030216 IEA     keratinocyte proliferation GO:0043616 IEA     positive regulation of DNA-templated transcription GO:0045893 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     cell development GO:0048468 IEA     roof of mouth development GO:0060021 IEA     limb development GO:0060173 IEA     mammary gland epithelial cell differentiation GO:0060644 ISS     stem cell proliferation GO:0072089 IEA     cranial skeletal system development GO:1904888 IEA     negative regulation of stem cell proliferation GO:2000647 IEA Subcellular Localization     chromatin GO:0000785 ISA     nucleus GO:0005634 IBA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     extracellular exosome GO:0070062 HDA