Gene description for SEC13
Gene name SEC13 homolog (S. cerevisiae)
Gene symbol SEC13
Other names/aliases D3S1231E
SEC13L1
SEC13R
npp-20
Species Homo sapiens
 Database cross references - SEC13
ExoCarta ExoCarta_6396
Entrez Gene 6396
HGNC 10697
MIM 600152
UniProt P55735  
 SEC13 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for SEC13
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    small GTPase mediated signal transduction GO:0007264 TAS
    post-translational protein modification GO:0043687 TAS
    COPII vesicle coating GO:0048208 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS
    ER to Golgi vesicle-mediated transport GO:0006888 TAS
    cellular protein metabolic process GO:0044267 TAS
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    mitotic cell cycle GO:0000278 TAS
    intracellular protein transport GO:0006886 NAS
    membrane organization GO:0061024 TAS
    mRNA transport GO:0051028 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    extracellular exosome GO:0070062 IDA
    nuclear pore outer ring GO:0031080 NAS
    Golgi membrane GO:0000139 TAS
    ER to Golgi transport vesicle membrane GO:0012507 TAS
    kinetochore GO:0000776 IDA
    nuclear envelope GO:0005635 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified SEC13 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SEC13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUP160 23279
Affinity Capture-Western Homo sapiens
2 NUP107  
Affinity Capture-Western Homo sapiens
3 WDR44 54521
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
4 NUP133  
Affinity Capture-Western Homo sapiens
5 N/A  
Affinity Capture-Western Homo sapiens
6 SEC31A 22872
Affinity Capture-Western Homo sapiens
7 NUP37  
Affinity Capture-Western Homo sapiens
8 RGPR  
Two-hybrid Homo sapiens
View the network image/svg+xml



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