Gene description for SOX5
Gene name SRY (sex determining region Y)-box 5
Gene symbol SOX5
Other names/aliases L-SOX5
L-SOX5B
L-SOX5F
Species Homo sapiens
 Database cross references - SOX5
ExoCarta ExoCarta_6660
Entrez Gene 6660
HGNC 11201
MIM 604975
UniProt P35711  
 SOX5 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SOX5
Molecular Function
    transcription regulatory region DNA binding GO:0044212 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    protein heterodimerization activity GO:0046982 IEA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IEA
Biological Process
    cell fate commitment GO:0045165 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IEA
    cartilage development GO:0051216 IEA
    positive regulation of cartilage development GO:0061036 IDA
    in utero embryonic development GO:0001701 IEA
    transcription from RNA polymerase II promoter GO:0006366 IEA
    positive regulation of mesenchymal stem cell differentiation GO:2000741 IDA
    oligodendrocyte differentiation GO:0048709 IEA
    positive regulation of chondrocyte differentiation GO:0032332 IDA
    regulation of timing of neuron differentiation GO:0060164 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    central nervous system neuron differentiation GO:0021953 IEA
Subcellular Localization
    nuclear transcription factor complex GO:0044798 IEA
 Experiment description of studies that identified SOX5 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SOX5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SOX5 is involved
No pathways found





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