Gene description for CHD6
Gene name chromodomain helicase DNA binding protein 6
Gene symbol CHD6
Other names/aliases CHD-6
CHD5
RIGB
Species Homo sapiens
 Database cross references - CHD6
ExoCarta ExoCarta_84181
Entrez Gene 84181
HGNC 19057
MIM 616114
UniProt Q8TD26  
 CHD6 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CHD6
Molecular Function
    ATP binding GO:0005524 IEA
    DNA-dependent ATPase activity GO:0008094 IDA
    DNA binding GO:0003677 IEA
    chromatin binding GO:0003682 IEA
    transcription cofactor binding GO:0001221 IPI
    ATP-dependent helicase activity GO:0008026 IEA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    chromatin modification GO:0016568 IEA
    positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0036091 IMP
Subcellular Localization
    DNA-directed RNA polymerase II, core complex GO:0005665 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified CHD6 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CHD6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CHD6 is involved
No pathways found





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