Gene description for MECP2
Gene name methyl CpG binding protein 2
Gene symbol MECP2
Other names/aliases AUTSX3
MRX16
MRX79
MRXS13
MRXSL
PPMX
RS
RTS
RTT
Species Homo sapiens
 Database cross references - MECP2
ExoCarta ExoCarta_4204
Vesiclepedia VP_4204
Entrez Gene 4204
HGNC 6990
MIM 300005
UniProt P51608  
 MECP2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
Thymus 23844026    
 Gene ontology annotations for MECP2
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    poly(A) RNA binding GO:0044822 IDA
    methyl-CpG binding GO:0008327 IBA
    DNA binding GO:0003677 TAS
    transcription factor binding GO:0008134 IEA
    chromatin binding GO:0003682 IEA
    protein N-terminus binding GO:0047485 IPI
    double-stranded methylated DNA binding GO:0010385 IMP
    transcription corepressor activity GO:0003714 TAS
    siRNA binding GO:0035197 IEA
    protein binding GO:0005515 IPI
    mRNA binding GO:0003729 IEA
    protein domain specific binding GO:0019904 IPI
    histone deacetylase binding GO:0042826 IEA
Biological Process
    glucocorticoid metabolic process GO:0008211 IEA
    neuron maturation GO:0042551 IEA
    respiratory gaseous exchange GO:0007585 IEA
    post-embryonic development GO:0009791 IEA
    long-term synaptic potentiation GO:0060291 IEA
    proprioception GO:0019230 IEA
    cerebellum development GO:0021549 IEA
    ventricular system development GO:0021591 IEA
    long-term memory GO:0007616 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IEA
    regulation of excitatory postsynaptic membrane potential GO:0060079 IEA
    synapse assembly GO:0007416 IEA
    behavioral fear response GO:0001662 IEA
    locomotory behavior GO:0007626 IBA
    regulation of gene expression by genetic imprinting GO:0006349 IEA
    inositol metabolic process GO:0006020 IEA
    protein localization GO:0008104 IEA
    sensory perception of pain GO:0019233 IEA
    negative regulation of histone acetylation GO:0035067 IEA
    cardiolipin metabolic process GO:0032048 IEA
    social behavior GO:0035176 IEA
    pathogenesis GO:0009405 IEA
    startle response GO:0001964 IEA
    phosphatidylcholine metabolic process GO:0046470 IEA
    transcription, DNA-templated GO:0006351 IEA
    adult locomotory behavior GO:0008344 IEA
    histone acetylation GO:0016573 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 IEA
    catecholamine secretion GO:0050432 IEA
    dendrite development GO:0016358 IEA
    positive regulation of cell proliferation GO:0008284 IEA
    visual learning GO:0008542 IEA
    positive regulation of synapse assembly GO:0051965 IEA
    response to hypoxia GO:0001666 IEA
    histone methylation GO:0016571 IEA
    negative regulation of histone methylation GO:0031061 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    response to radiation GO:0009314 IBA
    negative regulation of neuron apoptotic process GO:0043524 IEA
    glutamine metabolic process GO:0006541 IEA
    chromatin silencing GO:0006342 IEA
    regulation of respiratory gaseous exchange by neurological system process GO:0002087 IEA
    neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 IEA
    extracellular space GO:0005615 IDA
    cytosol GO:0005829 IBA
    heterochromatin GO:0000792 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified MECP2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
6
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MECP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIN3A  
Invivo Homo sapiens
2 PRPF40A 55660
Far Western Homo sapiens
Affinity Capture-MS Homo sapiens
3 SKI 6497
Invivo Homo sapiens
Invitro Homo sapiens
4 NCOR1  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which MECP2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here