Gene description for CDSN
Gene name corneodesmosin
Gene symbol CDSN
Other names/aliases HTSS
HTSS1
HYPT2
PSS
PSS1
S
Species Homo sapiens
 Database cross references - CDSN
ExoCarta ExoCarta_1041
Vesiclepedia VP_1041
Entrez Gene 1041
HGNC 1802
MIM 602593
UniProt Q15517  
 CDSN identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for CDSN
Molecular Function
    protein homodimerization activity GO:0042803 IBA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    corneocyte desquamation GO:0003336 IMP
    cell adhesion GO:0007155 TAS
    epidermis development GO:0008544 TAS
    keratinocyte differentiation GO:0030216 NAS
    skin morphogenesis GO:0043589 IMP
    cell-cell adhesion GO:0098609 IBA
    cell-cell adhesion GO:0098609 IDA
    negative regulation of cornification GO:1905716 IMP
    amyloid fibril formation GO:1990000 EXP
    amyloid fibril formation GO:1990000 IDA
Subcellular Localization
    cornified envelope GO:0001533 IDA
    cornified envelope GO:0001533 TAS
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 TAS
    desmosome GO:0030057 IDA
    desmosome GO:0030057 NAS
 Experiment description of studies that identified CDSN in exosomes
1
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDSN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 ENKD1  
Two-hybrid Homo sapiens
3 EPHX4 253152
Affinity Capture-MS Homo sapiens
4 SPRTN  
Affinity Capture-MS Homo sapiens
5 VSNL1 7447
Two-hybrid Homo sapiens
6 C3orf58 205428
Affinity Capture-MS Homo sapiens
7 FAM9B  
Two-hybrid Homo sapiens
8 SPSB4  
Affinity Capture-MS Homo sapiens
9 RAB9B 51209
Affinity Capture-MS Homo sapiens
10 KCNIP3  
Two-hybrid Homo sapiens
11 PI4KA 5297
Affinity Capture-MS Homo sapiens
12 GPATCH2L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 GSDMA 284110
Affinity Capture-MS Homo sapiens
14 B3GNT2 10678
Affinity Capture-MS Homo sapiens
15 ST8SIA1  
Affinity Capture-MS Homo sapiens
16 CA8  
Affinity Capture-MS Homo sapiens
17 HGS 9146
Two-hybrid Homo sapiens
18 UBQLN1 29979
Two-hybrid Homo sapiens
19 UCHL5 51377
Reconstituted Complex Homo sapiens
20 MECP2 4204
Affinity Capture-MS Homo sapiens
21 IFNA4  
Affinity Capture-MS Homo sapiens
22 OAZ3  
Affinity Capture-MS Homo sapiens
23 UBQLN4 56893
Two-hybrid Homo sapiens
24 ADSS 159
Affinity Capture-MS Homo sapiens
25 C18orf21  
Affinity Capture-MS Homo sapiens
26 HPCAL4  
Two-hybrid Homo sapiens
27 TRIM8  
Affinity Capture-MS Homo sapiens
28 ZDHHC17 23390
Two-hybrid Homo sapiens
29 BANP  
Two-hybrid Homo sapiens
30 ZNF550  
Affinity Capture-MS Homo sapiens
31 RPP14  
Affinity Capture-MS Homo sapiens
32 VAV1 7409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CEP55 55165
Two-hybrid Homo sapiens
34 USP11 8237
Affinity Capture-MS Homo sapiens
35 ZDHHC19  
Affinity Capture-MS Homo sapiens
36 CSTF2 1478
Two-hybrid Homo sapiens
37 DEFB106A  
Affinity Capture-MS Homo sapiens
38 WRAP73 49856
Affinity Capture-MS Homo sapiens
39 BAG6 7917
Two-hybrid Homo sapiens
40 ARG1 383
Affinity Capture-MS Homo sapiens
41 CCDC51 79714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 FANCG 2189
Affinity Capture-MS Homo sapiens
43 FIBIN  
Affinity Capture-MS Homo sapiens
44 NCS1 23413
Two-hybrid Homo sapiens
45 YWHAQ 10971
Affinity Capture-MS Homo sapiens
46 ALDH3A1 218
Affinity Capture-MS Homo sapiens
47 CTNNA3  
Two-hybrid Homo sapiens
48 SCN3B  
Affinity Capture-MS Homo sapiens
49 CYLD  
Affinity Capture-MS Homo sapiens
50 TMEM62  
Affinity Capture-MS Homo sapiens
51 CASP14 23581
Affinity Capture-MS Homo sapiens
52 CHCHD5  
Affinity Capture-MS Homo sapiens
53 FANCD2  
Affinity Capture-MS Homo sapiens
54 CCNC  
Affinity Capture-MS Homo sapiens
55 CSTF2T  
Two-hybrid Homo sapiens
56 NELFCD 51497
Two-hybrid Homo sapiens
57 JADE1  
Affinity Capture-MS Homo sapiens
58 UBQLN2 29978
Two-hybrid Homo sapiens
59 SLC35F2 54733
Affinity Capture-MS Homo sapiens
60 ZC3HC1  
Affinity Capture-MS Homo sapiens
61 PDPK1 5170
Affinity Capture-MS Homo sapiens
62 C21orf59 56683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 TGM7  
Two-hybrid Homo sapiens
64 SGTB  
Two-hybrid Homo sapiens
65 PI4KAP1  
Affinity Capture-MS Homo sapiens
66 PLVAP 83483
Two-hybrid Homo sapiens
67 ITPRIPL1  
Two-hybrid Homo sapiens
68 BLMH 642
Affinity Capture-MS Homo sapiens
69 ASPH 444
Two-hybrid Homo sapiens
70 UBE2J2 118424
Affinity Capture-MS Homo sapiens
71 SGTA 6449
Two-hybrid Homo sapiens
72 PRKAB2 5565
Two-hybrid Homo sapiens
73 MMRN1 22915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 STX17 55014
Affinity Capture-MS Homo sapiens
75 TSGA10  
Two-hybrid Homo sapiens
76 PRSS16 10279
Affinity Capture-MS Homo sapiens
77 EIF3F 8665
Two-hybrid Homo sapiens
78 ADH1C 126
Affinity Capture-MS Homo sapiens
79 EXOC8 149371
Two-hybrid Homo sapiens
80 PARVG 64098
Two-hybrid Homo sapiens
81 CCHCR1  
Two-hybrid Homo sapiens
82 POLR2L 5441
Affinity Capture-MS Homo sapiens
83 ATXN1L  
Two-hybrid Homo sapiens
84 CDSN 1041
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
85 DSC1 1823
Affinity Capture-MS Homo sapiens
86 C1orf35  
Affinity Capture-MS Homo sapiens
87 KLK7 5650
Biochemical Activity Homo sapiens
88 OR2L13  
Affinity Capture-MS Homo sapiens
89 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
90 THAP4 51078
Affinity Capture-MS Homo sapiens
91 PINK1  
Affinity Capture-MS Homo sapiens
92 GOT1 2805
Affinity Capture-MS Homo sapiens
93 TRIM69 140691
Two-hybrid Homo sapiens
94 LCN2 3934
Two-hybrid Homo sapiens
95 ANXA2 302
Affinity Capture-MS Homo sapiens
96 CCR1  
Affinity Capture-MS Homo sapiens
97 GALNT9  
Affinity Capture-MS Homo sapiens
98 CUL4A 8451
Affinity Capture-MS Homo sapiens
99 C1orf146  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CDSN is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here