Gene description for C3orf58
Gene name chromosome 3 open reading frame 58
Gene symbol C3orf58
Other names/aliases DIA1
GoPro49
HASF
Species Homo sapiens
 Database cross references - C3orf58
ExoCarta ExoCarta_205428
Vesiclepedia VP_205428
Entrez Gene 205428
HGNC 28490
MIM 612200
UniProt Q8NDZ4  
 C3orf58 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for C3orf58
Biological Process
    negative regulation of smooth muscle cell apoptotic process GO:0034392 IDA
    regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 IBA
    regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 IDA
    cardiac muscle cell proliferation GO:0060038 IBA
    cardiac muscle cell proliferation GO:0060038 IDA
    positive regulation of protein kinase C activity GO:1900020 IGI
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    COPI vesicle coat GO:0030126 IBA
    COPI vesicle coat GO:0030126 IDA
 Experiment description of studies that identified C3orf58 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for C3orf58
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 HFE  
Affinity Capture-MS Homo sapiens
4 FOXA1  
Affinity Capture-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 TMEM106A  
Affinity Capture-MS Homo sapiens
7 RNF123 63891
Affinity Capture-MS Homo sapiens
8 CHRNA4  
Affinity Capture-MS Homo sapiens
9 CANX 821
Affinity Capture-MS Homo sapiens
10 HLA-G 3135
Affinity Capture-MS Homo sapiens
11 GP9 2815
Affinity Capture-MS Homo sapiens
12 LDLRAD1  
Affinity Capture-MS Homo sapiens
13 TPTE  
Affinity Capture-MS Homo sapiens
14 HTR3C  
Affinity Capture-MS Homo sapiens
15 CHRNA1  
Affinity Capture-MS Homo sapiens
16 PRG2  
Affinity Capture-MS Homo sapiens
17 ECEL1  
Affinity Capture-MS Homo sapiens
18 GOLPH3 64083
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 GOLPH3L 55204
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TSPAN18 90139
Affinity Capture-MS Homo sapiens
21 KLRD1  
Affinity Capture-MS Homo sapiens
22 CDSN 1041
Affinity Capture-MS Homo sapiens
23 SBSN 374897
Affinity Capture-MS Homo sapiens
24 CHRNB2  
Affinity Capture-MS Homo sapiens
25 ACACA 31
Negative Genetic Homo sapiens
26 COMTD1 118881
Affinity Capture-MS Homo sapiens
27 PLD3 23646
Affinity Capture-MS Homo sapiens
28 CHRNA9  
Affinity Capture-MS Homo sapiens
29 PBXIP1 57326
Affinity Capture-MS Homo sapiens
30 SDF2L1 23753
Affinity Capture-MS Homo sapiens
31 GORASP2 26003
Affinity Capture-MS Homo sapiens
32 GPR182  
Affinity Capture-MS Homo sapiens
33 NCEH1 57552
Affinity Capture-MS Homo sapiens
34 ST14 6768
Affinity Capture-MS Homo sapiens
35 PLD6  
Affinity Capture-MS Homo sapiens
36 SERPINA12  
Affinity Capture-MS Homo sapiens
37 GFAP 2670
Affinity Capture-MS Homo sapiens
38 ZACN  
Affinity Capture-MS Homo sapiens
39 HLA-C 3107
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which C3orf58 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here