Gene description for SBSN
Gene name suprabasin
Gene symbol SBSN
Other names/aliases UNQ698
Species Homo sapiens
 Database cross references - SBSN
ExoCarta ExoCarta_374897
Vesiclepedia VP_374897
Entrez Gene 374897
HGNC 24950
MIM 609969
UniProt Q6UWP8  
 SBSN identified in sEVs derived from the following tissue/cell type
Liver cancer cells 25265333    
Liver cancer cells 25265333    
Neuroblastoma cells 25944692    
Saliva 19199708    
 Gene ontology annotations for SBSN
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SBSN in sEVs
1
Experiment ID 266
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Wild type
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 268
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx-null HBV replicon plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
4
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for SBSN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INPP5A 3632
Affinity Capture-MS Homo sapiens
2 C3orf58 205428
Affinity Capture-MS Homo sapiens
3 NCALD 83988
Two-hybrid Homo sapiens
4 RAB9B 51209
Affinity Capture-MS Homo sapiens
5 ZNF674 641339
Affinity Capture-MS Homo sapiens
6 FNDC5  
Affinity Capture-MS Homo sapiens
7 PI4KA 5297
Affinity Capture-MS Homo sapiens
8 GSK3A 2931
Affinity Capture-MS Homo sapiens
9 B3GNT2 10678
Affinity Capture-MS Homo sapiens
10 KIF23 9493
Affinity Capture-MS Homo sapiens
11 MCM2 4171
Affinity Capture-MS Homo sapiens
12 LRRC10  
Affinity Capture-MS Homo sapiens
13 E2F6 1876
Affinity Capture-MS Homo sapiens
14 FBXW7  
Affinity Capture-MS Homo sapiens
15 Gsk3b  
Affinity Capture-MS Mus musculus
16 APIP 51074
Affinity Capture-MS Homo sapiens
17 PHF11 51131
Affinity Capture-MS Homo sapiens
18 Haus1  
Affinity Capture-MS Mus musculus
19 ZSCAN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CUL1 8454
Affinity Capture-MS Homo sapiens
21 AGPAT1 10554
Affinity Capture-MS Homo sapiens
22 YAF2  
Affinity Capture-MS Homo sapiens
23 NDUFS5 4725
Affinity Capture-MS Homo sapiens
24 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TRIM41 90933
Affinity Capture-MS Homo sapiens
26 ZNF550  
Affinity Capture-MS Homo sapiens
27 VAV1 7409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 C16orf70  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ZDHHC19  
Affinity Capture-MS Homo sapiens
30 MYCBPAP 84073
Affinity Capture-MS Homo sapiens
31 HEY2  
Affinity Capture-MS Homo sapiens
32 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CDH1 999
Proximity Label-MS Homo sapiens
34 FIBIN  
Affinity Capture-MS Homo sapiens
35 PIGT 51604
Affinity Capture-MS Homo sapiens
36 TOX4  
Affinity Capture-MS Homo sapiens
37 SSUH2  
Affinity Capture-MS Homo sapiens
38 ALDH3A1 218
Affinity Capture-MS Homo sapiens
39 Arhgap18  
Affinity Capture-MS Mus musculus
40 UPK1A 11045
Affinity Capture-MS Homo sapiens
41 CYLD  
Affinity Capture-MS Homo sapiens
42 DTL  
Affinity Capture-MS Homo sapiens
43 ST8SIA1  
Affinity Capture-MS Homo sapiens
44 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
45 FANCD2  
Affinity Capture-MS Homo sapiens
46 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
47 CCNC  
Affinity Capture-MS Homo sapiens
48 PLD4  
Affinity Capture-MS Homo sapiens
49 CCNYL1 151195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 Tnks  
Affinity Capture-MS Mus musculus
51 POLK  
Affinity Capture-MS Homo sapiens
52 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 NR3C1 2908
Affinity Capture-MS Homo sapiens
54 ZC3HC1  
Affinity Capture-MS Homo sapiens
55 FTH1 2495
Affinity Capture-MS Homo sapiens
56 SUSD3 203328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 C21orf59 56683
Affinity Capture-MS Homo sapiens
58 PI4KAP1  
Affinity Capture-MS Homo sapiens
59 ADSS 159
Affinity Capture-MS Homo sapiens
60 EDF1 8721
Affinity Capture-MS Homo sapiens
61 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 C18orf21  
Affinity Capture-MS Homo sapiens
63 MMRN1 22915
Affinity Capture-MS Homo sapiens
64 STX17 55014
Affinity Capture-MS Homo sapiens
65 CDC42EP4  
Affinity Capture-MS Homo sapiens
66 PRSS16 10279
Affinity Capture-MS Homo sapiens
67 PVRL2 5819
Affinity Capture-MS Homo sapiens
68 STK16 8576
Affinity Capture-MS Homo sapiens
69 VNN2  
Affinity Capture-MS Homo sapiens
70 SLC25A6 293
Affinity Capture-MS Homo sapiens
71 TP53 7157
Affinity Capture-MS Homo sapiens
72 MCM5 4174
Affinity Capture-MS Homo sapiens
73 EPHX4 253152
Affinity Capture-MS Homo sapiens
74 CCR1  
Affinity Capture-MS Homo sapiens
75 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 C1orf35  
Affinity Capture-MS Homo sapiens
77 MBNL1 4154
Affinity Capture-MS Homo sapiens
78 TRIM37  
Proximity Label-MS Homo sapiens
79 DDX3X 1654
Affinity Capture-MS Homo sapiens
80 ARHGAP36  
Affinity Capture-MS Homo sapiens
81 TEFM  
Affinity Capture-MS Homo sapiens
82 PINK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 GOT1 2805
Affinity Capture-MS Homo sapiens
84 OR2A4 79541
Affinity Capture-MS Homo sapiens
85 SLC1A1 6505
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 PHF8  
Affinity Capture-MS Homo sapiens
87 GUCY1A3  
Affinity Capture-MS Homo sapiens
88 P2RX6  
Affinity Capture-MS Homo sapiens
89 GALNT9  
Affinity Capture-MS Homo sapiens
90 CUL4A 8451
Affinity Capture-MS Homo sapiens
91 C1orf146  
Affinity Capture-MS Homo sapiens
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