Gene description for CUL1
Gene name	cullin 1
Gene symbol	CUL1
Other names/aliases	-
Species	Homo sapiens
Database cross references - CUL1
ExoCarta	ExoCarta_8454
Entrez Gene	8454
HGNC	2551
MIM	603134
UniProt	Q13616
CUL1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for CUL1

Molecular Function     ubiquitin protein ligase binding GO:0031625 IEA     protein binding GO:0005515 IPI     ubiquitin protein ligase activity GO:0061630 IBA Biological Process     protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA     organ morphogenesis GO:0009887 IEA     protein monoubiquitination GO:0006513 IEA     negative regulation of cell proliferation GO:0008285 TAS     intrinsic apoptotic signaling pathway GO:0097193 TAS     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISS     protein ubiquitination GO:0016567 IDA     innate immune response GO:0045087 TAS     positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS     G1/S transition of mitotic cell cycle GO:0000082 TAS     cell cycle arrest GO:0007050 TAS     G2/M transition of mitotic cell cycle GO:0000086 TAS     viral process GO:0016032 IEA     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     Notch signaling pathway GO:0007219 TAS     cell proliferation GO:0008283 IEA     regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 TAS     anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 TAS     mitotic cell cycle GO:0000278 TAS     circadian rhythm GO:0007623 TAS Subcellular Localization     SCF ubiquitin ligase complex GO:0019005 ISS     cytosol GO:0005829 TAS     cullin-RING ubiquitin ligase complex GO:0031461 IDA     nucleoplasm GO:0005654 TAS     Parkin-FBXW7-Cul1 ubiquitin ligase complex GO:1990452 IPI